Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 15, 2015, Pages 4749-4754

  Shen, Sam H ^a   Stauft, Charles B ^a,b   Gorbatsevych, Oleksandr ^a   Song, Yutong ^a   Ward, Charles B ^a,c   Yurovsky, Alisa ^a   Mueller, Steffen ^a,b   Futcher, Bruce ^a   Wimmer, Eckard ^a,b  

^a Department of Molecular Genetics and Microbiology ^*  (United States)

^b Codagenix Inc ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Arbovirus; Codon pair bias; Dengue; Vaccine

Indexed keywords

DENGUE VACCINE; LIVE VACCINE; CODON; NS3 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; VIRUS ANTIBODY; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARBOVIRUS; ARTICLE; CODON; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; FEMALE; GENOME; HUMAN; HUMAN CELL; INSECT; INSECT CELL; LD 50; MAMMAL; MAMMAL CELL; MOUSE; NEWBORN; NEWBORN PERIOD; NONHUMAN; PHYLUM; PLANT DISEASE; PRIORITY JOURNAL; VIROGENESIS; VIRUS GENOME; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; CYTOLOGY; DISEASE CARRIER; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; VERO CELL LINE; VIROLOGY; VIRUS INFECTION;

ANIMALIA; ARBOVIRUS; ARTHROPODA; CHORDATA; DENGUE VIRUS; HEXAPODA; MAMMALIA;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, VIRAL; ARBOVIRUSES; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CODON; DENGUE VIRUS; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HOST-PATHOGEN INTERACTIONS; HUMANS; INSECT VECTORS; MAMMALS; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA HELICASES; SERINE ENDOPEPTIDASES; VACCINES, ATTENUATED; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS DISEASES;

EID: 84928152193     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502864112     Document Type: Article

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