Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus

Virology

Volumn 450-451, Issue , 2014, Pages 132-139

  Ni, Yan Yan ^a   Zhao, Zhao ^a   Opriessnig, Tanja ^b   Subramaniam, Sakthivel ^a   Zhou, Lei ^a,c   Cao, Dianjun ^a   Cao, Qian ^a   Yang, Hanchun ^c   Meng, Xiang Jin ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Attenuation; GP5 gene; Porcine reproductive and respiratory syndrome virus (PRRSV); Synthetic attenuated virus engineering (SAVE)

Indexed keywords

PROTEIN GP5; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; DNA MODIFICATION; GENETIC ENGINEERING; GP5 GENE; HISTOPATHOLOGY; IN VITRO STUDY; NONHUMAN; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHETIC ATTENUATED VIRUS ENGINEERING; VIREMIA; VIRUS ATTENUATION; VIRUS GENE; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; WILD TYPE;

ATTENUATION; GP5 GENE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV); SYNTHETIC ATTENUATED VIRUS ENGINEERING (SAVE);

ANIMALS; BASE SEQUENCE; CODON; COMPUTER-AIDED DESIGN; GENETIC ENGINEERING; MOLECULAR SEQUENCE DATA; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 84891460319     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2013.12.009     Document Type: Article

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