Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Frontiers in Cellular Neuroscience

Volumn 9, Issue JAN2016, 2016, Pages

  Fuller, Heidi R ^a,b   Mandefro, Berhan ^c,d   Shirran, Sally L ^e   Gross, Andrew R ^c   Kaus, Anjoscha S ^c   Botting, Catherine H ^e   Morris, Glenn E ^a,b   Sareen, Dhruv ^c,d  

^a ROBERT JONES AND AGNES HUNT ORTHOPAEDIC HOSPITAL   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d The David and Janet Poiak Foundation Stem Cell Core Laboratory   (United States)

^e UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Human iPSCs; Motor neuron; Neuronal development; Proteomics; SMA; UBA1; UCHL1

Indexed keywords

BETA TUBULIN; CALDESMON; MESSENGER RNA; MYOSIN III; SYNAPTOPODIN; UBIQUITIN CARBOXYL TERMINAL HYDROLASE L1; UNCLASSIFIED DRUG; ZYXIN;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KARYOTYPING; MASS SPECTROMETRY; MOTONEURON; NERVE CELL DIFFERENTIATION; PLASMID; PLURIPOTENT STEM CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL MUSCULAR ATROPHY; WESTERN BLOTTING;

EID: 84957794006     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00506     Document Type: Article

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