Label-free quantitative proteomic profiling identifies disruption of ubiquitin homeostasis as a key driver of Schwann cell defects in spinal muscular atrophy

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 4546-4557

  Aghamaleky Sarvestany, Arwin ^a   Hunter, Gillian ^a   Tavendale, Amy ^b   Lamont, Douglas J ^b   Llavero Hurtado, Maica ^c   Graham, Laura C ^c   Wishart, Thomas M ^a,c   Gillingwater, Thomas H ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

label free proteomics; mouse; Schwann cell; SMA; spinal muscular atrophy; uba1; ubiquitin

Indexed keywords

PROTEOME; UBIQUITIN; UBIQUITIN LIKE MODIFIER ACTIVATING ENZYME 1; UNCLASSIFIED DRUG; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; MYELINATION; NONHUMAN; PERIPHERAL NERVE; PROTEOMICS; QUANTITATIVE ANALYSIS; SCHWANN CELL; SPINAL MUSCULAR ATROPHY; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CLUSTER ANALYSIS; CYTOLOGY; GENETICS; HOMEOSTASIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES;

ANIMALS; CLUSTER ANALYSIS; HOMEOSTASIS; MICE; MUSCULAR ATROPHY, SPINAL; PERIPHERAL NERVES; PROTEOMICS; SCHWANN CELLS; UBIQUITIN; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84908883064     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500492j     Document Type: Article

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