Quantitative proteomic analysis identifies targets and pathways of a 2-aminobenzamide HDAC inhibitor in Friedreichs ataxia patient iPSC-derived neural stem cells

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 4558-4566

  Shan, Bing ^a   Xu, Chunping ^b   Zhang, Yaoyang ^a   Xu, Tao ^a   Gottesfeld, Joel M ^b   Yates, John R ^a  

^a Department of Chemical Physiology ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

dimethyl labeling; FRDA; HDAC inhibitor; MudPIT

Indexed keywords

2 AMINOBENZAMIDE; FORMALDEHYDE; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; NUCLEAR PROTEIN; STREPTAVIDIN; ANTHRANILIC ACID DERIVATIVE; COMPOUND 106; MOLECULAR PROBE; PYRAZOLE DERIVATIVE; PYRIDINIUM DERIVATIVE;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DOWN REGULATION; FRIEDREICH ATAXIA; GENE ONTOLOGY; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOTOPE LABELING; MESSENGER RNA SYNTHESIS; NEURAL STEM CELL; PROTEIN ACETYLATION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA PROCESSING; RNA SPLICING; TANDEM MASS SPECTROMETRY; TRANSCRIPTION ELONGATION; WESTERN BLOTTING; MASS SPECTROMETRY; METABOLISM; MOLECULAR PROBE; PHARMACOLOGY; PHYSIOLOGY; PLURIPOTENT STEM CELL; PROCEDURES;

FRIEDREICH ATAXIA; HISTONE DEACETYLASE INHIBITORS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MASS SPECTROMETRY; MOLECULAR PROBES; NEURAL STEM CELLS; NUCLEAR PROTEINS; ORTHO-AMINOBENZOATES; PROTEOMICS; PYRAZOLES; PYRIDINIUM COMPOUNDS; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 84908886652     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500514r     Document Type: Article

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