Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers

Annals of Nutrition and Metabolism

Volumn 68, Issue 2, 2016, Pages 137-144

  Moon, Hyun Seuk ^a,b  

^a Korea University   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

Alpha lipoic acid; Anti cancer property; Metabolism; Obesity; Obesity related cancers

Indexed keywords

THIOCTIC ACID; ANTIOXIDANT;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER INHIBITION; CANCER PATIENT; CHEMOPROPHYLAXIS; COLON CANCER; DRUG EFFECT; DRUG SAFETY; HUMAN; IN VITRO STUDY; LIVER CANCER; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; OBESITY; OBESITY RELATED CANCER; PANCREAS CANCER; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; THYROID CANCER; TREATMENT OUTCOME; ANIMAL; COMPLICATION; NEOPLASMS;

ANIMALS; ANTIOXIDANTS; HUMANS; NEOPLASMS; OBESITY; THIOCTIC ACID;

EID: 84957668738     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000443994     Document Type: Review

References (83)

1. Katsareli EA, Dedoussis GV: Biomarkers in the field of obesity and its related comorbidities. Expert Opin Ther Targets 2014; 18: 385-401.
2. Kucukhuseyin O, Kurnaz O, Akadam-Teker AB, et al: The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease. J Clin Lab Anal 2013; 27: 427-434.
3. Razzaghi H, Troester MA, Gierach GL, et al: Mammographic density and breast cancer risk in white and African American women. Breast Cancer Res Treat 2012; 135: 571-580.
4. Abdel-Zaher AO, Abdel-Hady RH, Mahmoud MM, et al: The potential protective role of alpha-lipoic acid against acetaminopheninduced hepatic and renal damage. Toxicology 2008; 243: 261-270.
5. Spechler SJ: Barrett esophagus and risk of esophageal cancer: A clinical review. JAMA 2013; 310: 627-636.
6. Orecchioni S, Reggiani F, Talarico G, et al: Mechanisms of obesity in the development of breast cancer. Discov Med 2015; 20: 121-128.
7. Pellegriti G, Frasca F, Regalbuto C, et al: Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013; 2013: 965212.
8. Hemminki K, Li X, Sundquist J, et al: Obesity and familial obesity and risk of cancer. Eur J Cancer Prev 2011; 20: 438-443.
9. O'Flanagan CH, Bowers LW, Hursting SD: A weighty problem: metabolic perturbations and the obesity-cancer link. Horm Mol Biol Clin Investig 2015; 23: 47-57.
10. Szabo G, Saha B, Bukong TN: Alcohol and HCV: implications for liver cancer. Adv Exp Med Biol 2015; 815: 197-216.
11. Mazzarella L: Why does obesity promote cancer? Epidemiology, biology, and open questions. Ecancermedicalscience 2015; 9: 554.
12. Matsunaga T, Suzuki K, Imashimizu K, Banno T, Takamochi K, Oh S: Body mass index as a prognostic factor in resected lung cancer: obesity or underweight, which is the risk factor? Thorac Cardiovasc Surg 2015; 63: 551-557.
13. Tseng JH, Roche KL, et al: Lifestyle and weight management counseling in uterine cancer survivors: A study of the uterine cancer action network. Int J Gynecol Cancer 2015; 25: 1285-1291.
14. Travis LB, Demark Wahnefried W, et al: Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors. Nat Rev Clin Oncol 2013; 10: 289-301.
15. Chen J, Zhao KN, Li R, et al: Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer. Curr Med Chem 2014; 21: 3070-3080.
16. Habeeb BS, Kitayama J, Nagawa H: Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells. Cancer Sci 2011; 102: 999-1006.
17. Kubota Y, Iso H, Tamakoshi A; JACC Study Group: Association of body mass index and mortality in Japanese diabetic men and women based on self-reports: The Japan collaborative cohort (JACC) study. J Epidemiol 2015; 25: 553-558.
18. Mignini F, Nasuti C, Fedeli D, et al: Protective effect of alpha-lipoic acid on cypermethrininduced oxidative stress in Wistar rats. Int J Immunopathol Pharmacol 2013; 26: 871-881.
19. Dwivedi N, Flora G, Kushwaha P, et al: Alphalipoic acid protects oxidative stress, changes in cholinergic system and tissue histopathology during co-exposure to arsenic-dichlorvos in rats. Environ Toxicol Pharmacol 2014; 37: 7-23.
20. Keith DJ, Butler JA, Bemer B, et al: Age and gender dependent bioavailability of R-and R,S-α-lipoic acid: A pilot study. Pharmacol Res 2012; 66: 199-206.
21. Yamada T, Hashida K, Takarada-Iemata M, et al: α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion. Neurochem Int 2011; 59: 1003-1009.
22. Koga T, Ishida T, Takeda T, et al: Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid. PLoS One 2012; 7:e40322.
23. Shaafi S, Afrooz MR, Hajipour B, et al: Antioxidative effect of lipoic acid in spinal cord ischemia/reperfusion. Med Princ Pract 2011; 20: 19-22.
24. Valdecantos MP, Pérez-Matute P, Quintero P, et al: Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different. Redox Rep 2010; 15: 207-216.
25. Xia H, Nan Y, Huang X, et al: Effects of tauroursodeoxycholic acid and alpha-lipoic-acid on the visual response properties of cat retinal ganglion cells: an in vitro study. Invest Ophthalmol Vis Sci 2015; 56: 6638-6645.
26. Durand M, Mach N: [Alpha lipoic acid and its antioxidant against cancer and diseases of central sensitization]. Nutr Hosp 2013; 28: 1031-1038.
27. Moungjaroen J, Nimmannit U, Callery PS, et al: Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther 2006; 319: 1062-1069.
28. Dozio E, Ruscica M, Passafaro L, et al: The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur J Pharmacol 2010; 641: 29-34.
29. Trivedi PP, Jena GB: Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. Food Chem Toxicol 2013; 59: 339-355.
30. Omran OM, Omer OH: The effects of alphalipoic acid on breast of female albino rats exposed to malathion: histopathological and immunohistochemical study. Pathol Res Pract 2015; 211: 462-469.
31. Choi HJ, Kim TY, Ruiz-Llorente S, et al: Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line. Nucl Med Biol 2012; 39: 1275-1280.
32. Wenzel U, Nickel A, Daniel H: Alpha-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-∗-generation. Apoptosis 2005; 10: 359-368.
33. Berkson BM, Rubin DM, Berkson AJ: Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: A report of 3 new cases. Integr Cancer Ther 2009; 8: 416-422.
34. Ueda K, Asai Y, Yoshimura Y, et al: Effect of oil-in-water lipid emulsions prepared with fish oil or soybean oil on the growth of MCF-7 cells and HepG2 cells. J Pharm Pharmacol 2008; 60: 1069-1075.
35. Kumar P, Kadakol A, Shasthrula PK, et al: Curcumin as an adjuvant to breast cancer treatment. Anticancer Agents Med Chem 2015; 15: 647-656.
36. Na MH, Seo EY, Kim WK: Effects of alphalipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells. Nutr Res Pract 2009; 3: 265-271.
37. Dozio E, Ruscica M, Passafaro L, et al: The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur J Pharmacol 2010; 641: 29-34.
38. Feuerecker B, Pirsig S, Seidl C, et al: Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo. Cancer Biol Ther 2012; 13: 1425-1435.
39. Gatenby RA, Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-899.
40. Vander Heiden MG, Cantley LC, Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
41. Sugden MC, Holness MJ: Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 2003; 284:E855-E862.
42. Rossi C, Di Lena A, La Sorda R, et al: Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer. Eur J Cancer 2008; 44: 2696-2704.
43. Li LC, Liu GD, Zhang XJ, et al: Autophagy, a novel target for chemotherapeutic intervention of thyroid cancer. Cancer Chemother Pharmacol 2014; 73: 439-449.
44. Rajoria S, Hanly E, Nicolini A, et al: Interlinking of hypoxia and estrogen in thyroid cancer progression. Curr Med Chem 2014; 21: 1351-1360.
45. Jeon MJ, Kim WG, Lim S, et al: Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells. Mol Cell Endocrinol 2016; 419: 113-123.
46. Ridereau-Zins C: Imaging in colonic cancer. Diagn Interv Imaging 2014; 95: 475-483.
47. Sebio A, Kahn M, Lenz HJ: The potential of targeting Wnt/β-catenin in colon cancer. Expert Opin Ther Targets 2014; 18: 611-615.
48. Ishii N: Role of oxidative stress from mitochondria on aging and cancer. Cornea 2007; 26(9 suppl 1):S3-S9.
49. Kang J, Chong SJ, Ooi VZ, et al: Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide. Oncotarget 2015; 6: 34191-34205.
50. Park S, Choi SK, Choi Y, et al: AMPK/p53 axis is essential for α-lipoic acid-regulated metastasis in human and mouse colon cancer cells. J Investig Med 2015; 63: 882-885.
51. Yoo TH, Lee JH, Chun HS, et al: Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-κB induction of RPS6KA4. Anticancer Drugs 2013; 24: 555-565.
52. Hiratsuka T, Inomata M, Kono Y, et al: DHL-TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells. Oncol Rep 2013; 29: 2140-2146.
53. Cao Z, Tian R, Zhang T, et al: Localized autoimmune pancreatitis: report of a case clinically mimicking pancreatic cancer and a literature review. Medicine (Baltimore) 2015; 94:e1656.
54. Schmidt-Hansen M, Berendse S, Hamilton W: Symptoms of pancreatic cancer in primary care: A systematic review. Pancreas 2015, Epub ahead of print.
55. Takai E, Yachida S: Genomic alterations in pancreatic cancer and their relevance to therapy. World J Gastrointest Oncol 2015; 7: 250-258.
56. Timofte D, Livadariu R, Bintintan V, et al: Metabolic disorders in patients operated for pancreatic cancer. Rev Med Chir Soc Med Nat Iasi 2014; 118: 392-398.
57. Fiore M, de Stefano G, Coppola N, et al: Synchronous and metachronous gastric gist with pancreatic adenocarcinoma: report of 2 cases and a review of literature. Gastroenterol Hepatol Bed Bench 2015; 8: 298-301.
58. Kim HS, Kim HJ, Park KG, et al: Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity. Exp Mol Med 2007; 39: 106-113.
59. Guais A, Baronzio G, Sanders E, et al: Adding a combination of hydroxycitrate and lipoic acid (METABLOC TM ) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012; 30: 200-211.
60. Berkson BM, Rubin DM, Berkson AJ: Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: A report of 3 new cases. Integr Cancer Ther 2009; 8: 416-422.
61. Wang F, Wang H, Sun X, et al: Apoptosis-induction is a novel therapeutic strategy for gastrointestinal and liver cancers. Curr Gene Ther 2015; 15: 193-200.
62. Djenic B, Duick D, Newell JO, et al: Solitary liver metastasis from follicular variant papillary thyroid carcinoma: A case report and literature review. Int J Surg Case Rep 2015; 6C: 146-149.
63. Fang C, Fang C, Tian J: [The clinical application of near-infrared light imaging mediated by indocyanine green in liver cancer surgery]. Zhonghua Wai Ke Za Zhi 2015; 53: 155-157.
64. Montella M, D'Arena G, Crispo A, et al: Role of sex hormones in the development and progression of hepatitis B virus-associated hepatocellular carcinoma. Int J Endocrinol 2015; 2015: 854530.
65. Ringelhan M, Protzer U: Oncogenic potential of hepatitis B virus encoded proteins. Curr Opin Virol 2015; 14: 109-115.
66. Oh IS, Park SH: Immune-mediated liver injury in hepatitis B virus infection. Immune Netw 2015; 15: 191-198.
67. Shi DY, Liu HL, Stern JS, et al: Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett 2008; 582: 1667-1671.
68. Fujii Y, Segawa R, Kimura M, et al: Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats. Chem Biol Interact 2013; 205: 108-118.
69. Simbula G, Columbano A, Ledda-Columbano GM, et al: Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 2007; 12: 113-123.
70. Sudheesh NP, Ajith TA, Janardhanan KK: Hepatoprotective effects of DL-α-lipoic acid and α-tocopherol through amelioration of the mitochondrial oxidative stress in acetaminophen challenged rats. Toxicol Mech Methods 2013; 23: 368-376.
71. Perra A, Pibiri M, Sulas P, et al: Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model. Carcinogenesis 2008; 29: 161-168.
72. Zhang A, Silverberg JI: Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis. J Am Acad Dermatol 2015; 72: 606-616.
73. Simmonds M, Burch J, Llewellyn A, et al: The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: A systematic review and meta-analysis. Health Technol Assess 2015; 19: 1-336.
74. Mastrangelo G, Fadda E, Cegolon L: Endotoxin and cancer chemo-prevention. Cancer Epidemiol 2013; 37: 528-533.
75. Genova C, Rijavec E, Truini A, et al: Pemetrexed for the treatment of non-small cell lung cancer. Expert Opin Pharmacother 2013; 14: 1545-1558.
76. Koufaki M: Therapeutic applications of lipoic acid: A patent review (2011-2014). Expert Opin Ther Pat 2014; 24: 993-1005.
77. Marshall AW, Graul RS, Morgan MY, et al: Treatment of alcohol-related liver disease with thioctic acid: A six month randomised double-blind trial. Gut 1982; 23: 1088-1093.
78. Kähler W, Kuklinski B, Rühlmann C, et al: [Diabetes mellitus-A free radical-associated disease. Results of adjuvant antioxidant supplementation]. Z Gesamte Inn Med 1993; 48: 223-232.
79. McMackin CJ, Widlansky ME, Hamburg NM: Effect of combined treatment with alpha-lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich) 2007; 9: 249-255.
80. Jariwalla RJ, Lalezari J, Cenko D, et al: Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection. J Altern Complement Med 2008; 14: 139-146.
81. Lott IT, Doran E, Nguyen VQ, et al: Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation. Am J Med Genet A 2011; 155A:1939-1948.
82. Mantovani G, Macciò A, Madeddu C, et al: Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant treatment. J Cell Mol Med 2002; 6: 570-582.
83. Mantovani G, Macciò A, Madeddu C, et al: Phase II study of subcutaneously administered interleukin-2 in combination with medroxyprogesterone acetate and antioxidant agents as maintenance treatment in advanced cancer responders to previous chemotherapy. Oncol Rep 2002; 9: 887-896.