Endotoxin and cancer chemo-prevention

Cancer Epidemiology

Volumn 37, Issue 5, 2013, Pages 528-533

  Mastrangelo, Giuseppe ^a   Fadda, Emanuela ^a   Cegolon, Luca ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Allergy vaccine; Cancer; Chemo prevention; Endotoxin; Epidemiology; Monophosphoryl lipid A

Indexed keywords

ANTINEOPLASTIC AGENT; ENDOTOXIN; MPL; PHOSPHORYL LIPID A; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VACCINE;

ALLERGIC RHINITIS; ALLERGIC RHINOCONJUNCTIVITIS; ALLERGY; ANTINEOPLASTIC ACTIVITY; CANCER INCIDENCE; CANCER MORTALITY; CANCER PREVENTION; CANCER THERAPY; CHEMOPROPHYLAXIS; EUROPE; HEART DISEASE; HUMAN; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; OBSERVATIONAL STUDY; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; REVIEW; RHINOCONJUNCTIVITIS;

ALLERGY VACCINE; CANCER; CHEMO-PREVENTION; ENDOTOXIN; EPIDEMIOLOGY; MONOPHOSPHORYL LIPID A;

ANTICARCINOGENIC AGENTS; ENDOTOXINS; HUMANS; LIPID A; NEOPLASMS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE;

EID: 84884135021     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2013.04.008     Document Type: Review

References (50)

1. National Vital Statistics Reports. Available at: (accessed in January 2013). http://www.cdc.gov/nchs/products/nvsr.htm.
2. New Zealand Health Information and Service Mortality and demographic data 2002 and 2003 2006, Ministry of Health, Available at: http://www.nzhis.govt.nz/moh.nsf/pagesns/528 (accessed in January 2013).
3. WHO Europe Highlights on health in France 2004, Available at: www.euro.who.int/__data/assets/pdf_file/0020/103853/E88547.pdf (accessed in January 2013).
4. WHO Global Infobase: proportional mortality. Available at: (access in January 2013). https://apps.who.int/infobase/Mortality.aspx.
5. Aouba A., Péquignot F., Le Toullec A., Jougla E. Les causes médicales de décès en France et leurs évolutions récentes, 1980-2004. Bul Epidémiol Hebd 2007, 35-36:308-314. Available: http://www.parisnord.idf.inserm.fr/paris7/fr/recherche_pour_tous/Comprendre/Atlas_de_la_mortalite_par_cancer.html (accessed in January 2013).
6. Statistics Canada. Available at: (accessed in January 2013). http://www.statcan.gc.ca/.
7. Statistics Netherlands. Cancer number one cause of death in 2008. Available at: (accessed in January 2013). http://www.cbs.nl/enGB/menu/themas/gezondheidwelzijn/publicaties/artikelen/archief/2009/2009-2687-wm.htm.
8. Intenational Agency for Research on Cancer (IARC). Globocan 2008. Available at: (accessed in January 2013). http://globocan.iarc.fr/.
9. Mariotto A.B., Yabroff K.B., Shao Y., Feuer E.J., Brown M.L. Projections of the cost of cancer care in the United States: 2010-2020. JNCI 2011, 103:117-123.
10. U.S.Census Bureau Population division: interim projections consistent with census 2000 (released March 2004) 2008, U.S. Census Bureau, Population Division, Washington D.C., (accessed July 2008). http://www.census.gov/population/www/projections/usinterimproj/.
11. Boffetta P., Couto E., Wichmann J., Ferrari P., Trichopoulos D., Bueno-de-Mesquita H.B., et al. Fruit and vegetable intake and overall cancer risk in the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer Inst 2010, 102:529-537.
12. Hung H.C., Joshipura K.J., Hu F.B., Hunter D., Smith-Warner S.A., Colditz G.A., et al. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004, 96(21):1577-1584.
13. Abrams D. Comprehensive smoking cessation policy for all smokers: systems integration to save lives and money. Ending the tobacco problem: a blueprint for the nation 2007, The National Academies Press, Washington. R.J. Bonnie, K. Stratton, R.B. Wallace (Eds.).
14. Orleans C.T. Increasing the demand for and use of effective smoking-cessation treatments reaping the full health benefits of tobacco-control science and policy gains-in our lifetime. Am J Prev Med 2007, 33(6S):S340-S348.
15. Gollust S., Schroeder S., Warner K. Helping smokers quit: understanding the barriers to utilization of smoking cessation services. Millbank Q 2008, 86(4):601-627.
16. Levy T.D., Graham A.L., Mabry P.L., Abrams D.B., Orleans T.B. Modeling the impact of smoking-cessation treatment policies on quit rates. Am J Prev Med 2010, 38(3S):S364-S372.
17. Hughes J.R., Peters E.N., Naud S. Relapse to smoking after 1 year of abstinence: a meta-analysis. Addict Behav 2008, 33(12):1516-1520.
18. Hajek P., Stead L.F., West R., Jarvis M., Lancaster T. Relapse prevention interventions for smoking cessation (Review). Cochrane Libr, Issue 1 2009, Available at: www.thecochranelibrary.com (accessed in January 2013).
19. Anderson C.M., Yip R., Henschke C.I., Yankelevitz D.F., Ostroff J.S., Burns D.M. Smoking cessation and relapse during a lung cancer screening program. Cancer Epidemiol Biomarkers Prev 2009, 18(12):3476-3483.
20. Wiehe S.E., Garrison M.M., Christakis D.A., Ebel B.E., Rivara F.P. A systematic review of school-based smoking prevention trials with long-term follow-up. J Adolesc Health 2005, 36:162-169.
21. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., et al. Cancer statistics, 2008, CA. Cancer J Clin 2008, 58:71-96.
22. Center for Diseases Prevention and Control (CDC) website. Alcohol & Public Health. Available at: (accessed in January 2013). http://www.cdc.gov/alcohol/.
23. Foxcroft D.R., Ireland D., Lister-Sharp D.J., Lowe G., Breen R. Longer-term primary prevention for alcohol misuse in young people: a systematic review. Addiction 2003, 98(4):397-411. Review.
24. UICC (2005). Cancer can be prevented too. Available at: (accessed in January 2013). http://www.worldcancercampaign.org/index.php%3Foption=com_content%26task=view%26id=273%26Itemid=586.
25. Hiene H., Rietschel T., Ulmer A.J. The biology of endotoxin. Mol Biotechnol 2001, 19:279-296.
26. Ulmer A. Biochemistry and biology of endotoxins. Int J Occup Environ Health 1997, 3(Suppl.):S8-S17.
27. Liebers V., Brüning T., Raulf-Heimsoth M. Occupational endotoxin-exposure and possible health effects on humans. Am J Ind Med 2006, 49:474-491.
28. Sordillo J.E., Sordillo J.E., Hoffman E.B., Celedón J.C., Litonjua A.A., Milton D.K., et al. Multiple microbial exposures in the home may protect against asthma or allergy in childhood. Clin Exp Allergy 2010, 40:902-910.
29. Lenters V., Basinas I., Beane-Freeman L., Boffetta P., Checkoway H., Coggon D., et al. Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers. Cancer Causes Control 2009, 10.1007/s10552-009-9483-z.
30. Mastrangelo G., Marzia V., Marcer G. Reduced lung cancer mortality in dairy farmers: is endotoxin exposure the key factor?. Am J Ind Med 1996, 30:601-609.
31. Mastrangelo G., Grange J.M., Fadda E., Fedeli U., Buja A., Lange J.H. Lung cancer risk: effect of dairy farming and the consequence of removing that occupational exposure. Am J Epidemiol 2005, 161(June (11)):1037-1046.
32. Laakkonen A., Pukkala E. Cancer incidence among Finnish farmers, 1995-2005. Scand J Work Environ Health 2008, 34(February (1)):73-79.
33. Astrakianakis G., Seixas N.S., Ray R., Camp J.E., Gao D.L., Feng Z., et al. Lung cancer risk among female textile workers exposed to endotoxin. J Natl Cancer Inst 2007, 99:357-364.
34. Koskela R.S., Klockars M., Jarvinen E. Mortality and disability among cotton mill workers. Br J Ind Med 1990, 47:384-391.
35. Wernli K.J., Fitzgibbons E.D., Ray R.M., Gao D.L., Li W., Seixas N.S., et al. Occupational risk factors for esophageal and stomach cancers among female textile workers in Shanghai. Chin Am J Epidemiol 2006, 163(8):717-725. 15.
36. De Roos A.J., Ray R.M., Gao D.L., Wernli K.J., Fitzgibbons E.D., Ziding F., et al. Colorectal cancer incidence among female textile workers in Shanghai, China: a case-cohort analysis of occupational exposures. Cancer Causes Control 2005, 16(10):1177-1188.
37. Chang C.K., Astrakianakis G., Thomas D.B., Seixas N.S., Ray R.M., Gao D.L., et al. Occupational exposures and risks of liver cancer among Shanghai female textile workers--a case-cohort study. Int J Epidemiol 2006, 35(2):361-369.
38. Li W., Ray R.M., Fitzgibbons E.D., Seixas N.S., Camp J.E., Wernli K.J., et al. Occupational risk factors for pancreatic cancer among female textile workers in Shanghai. Chin Occup Environ Med 2006, 63:788-793.
39. Ray R.M., Gao D.L., Li W., Wernlii K.J., Astrakianakis G., Seixas N.S., et al. Occupational exposures and breast cancer among women textile workers in Shanghai. Epidemiology 2007, 18:383-392.
40. Liebers V., Raulf-Heimsoth M., Bruning T. Health effects due to endotoxin inhalation (review). Arch Toxicol 2008, 82:203-210.
41. Allergy Therapeutics. Available at: (accessed in January 2013). http://www.allergytherapeutics.com/search.aspx%3Fkw=pollinex+quattro.
42. Patel P., Salapatek A.M. Pollinex Quattro: a novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines 2006, 5(October (5)):617-629.
43. McCormack P.L., Wagstaff A.J. Ultra-short-course seasonal allergy vaccine (Pollinex Quattro). Drugs 2006, 66(7):931-938.
44. Cluff C.W. Monophosphoryl Lipid A, (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol 2009, 667:111-123.
45. Glaxo Smith-Kline. Available at: (accessed on February 2013). http://www.gsk.com/products/our-vaccines.html.
46. Hobohm U. Toward general prophylactic cancer vaccination. BioEssays 2009, 31:1071-1079.
47. Lundin J.I., Checkoway H. Endotoxin and cancer. Environ Health Perspect 2009, 117(9):1344-1350.
48. Boffetta P. Endotoxins in lung cancer prevention. JNCI 2007, 99(5):339.
49. Verstraeten T., Descamps D., David M.P., Zahaf T., Hardt K., Izurieta P., et al. Analysis of adverse events of potential autoimmune aetiology in a large integrated safety database of AS04 adjuvanted vaccines. Vaccine 2008, 26(December (51)):6630-6638.
50. Keith R.L. Chemoprevention of lung cancer. Am Thorac Soc 2009, 6:187-193.