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Volumn 15, Issue 5, 2010, Pages 207-216

Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: All antioxidants but different

Author keywords

antioxidant; mitochondria; oxidative stress; reactive oxygen species

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; RESVERATROL; THIOCTIC ACID;

EID: 78049513314     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/135100010X12826446921464     Document Type: Article
Times cited : (68)

References (52)
  • 2
    • 63849316486 scopus 로고    scopus 로고
    • Therapeutic interventions and oxidative stress in diabetes
    • Rahangdale S, Yeh SY, Malhotra A, Veves A. Therapeutic interventions and oxidative stress in diabetes. Front Biosci 2009; 14: 192-209.
    • (2009) Front. Biosci. , vol.14 , pp. 192-209
    • Rahangdale, S.1    Yeh, S.Y.2    Malhotra, A.3    Veves, A.4
  • 3
    • 67349091737 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome
    • Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 2009; 84: 705-712.
    • (2009) Life Sci. , vol.84 , pp. 705-712
    • Roberts, C.K.1    Sindhu, K.K.2
  • 4
    • 33644633736 scopus 로고    scopus 로고
    • Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
    • Lond
    • Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006; 30: 400-418.
    • (2006) Int J Obes , vol.30 , pp. 400-418
    • Vincent, H.K.1    Taylor, A.G.2
  • 5
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994; 74: 139-162.
    • (1994) Physiol. Rev. , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 7
    • 34249084004 scopus 로고    scopus 로고
    • Role of free radicals and antioxidants in health and disease
    • Flora SJ. Role of free radicals and antioxidants in health and disease. Cell Mol Biol (Noisy-le-grand) 2007; 53: 1-2.
    • (2007) Cell Mol Biol Noisy-le-grand , vol.53 , pp. 1-2
    • Flora, S.J.1
  • 8
    • 34948836246 scopus 로고    scopus 로고
    • Adiposity dependent apelin gene expression: Relationships with oxidative and inflammation markers
    • Garcia-Diaz D, Campion J, Milagro FI, Martinez JA. Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. Mol Cell Biochem 2007; 305: 87-94.
    • (2007) Mol. Cell. Biochem. , vol.305 , pp. 87-94
    • Garcia-Diaz, D.1    Campion, J.2    Milagro, F.I.3    Martinez, J.A.4
  • 9
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev 2006; 5: 493-506.
    • (2006) Nat. Rev. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 11
    • 77249098795 scopus 로고    scopus 로고
    • Dehydroascorbic acid as preconditioner: protection from lipopolysaccharide induced mitochondrial damage
    • Lowes DA, Webster NR, Galley HF. Dehydroascorbic acid as preconditioner: protection from lipopolysaccharide induced mitochondrial damage. Free Radic Res 2010; 44: 283-292.
    • Free Radic. Res. , vol.2010 , Issue.44 , pp. 283-292
    • Lowes, D.A.1    Webster, N.R.2    Galley, H.F.3
  • 12
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • Brookins Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med 2009; 46: 1589-1597.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 1589-1597
    • Brookins Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 13
    • 38349053821 scopus 로고    scopus 로고
    • Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD
    • Robb EL, Page MM, Wiens BE, Stuart JA. Molecular mechanisms of oxidative stress resistance induced by resveratrol: specific and progressive induction of MnSOD. Biochem Biophys Res Commun 2008; 367: 406-412.
    • (2008) Biochem. Biophys. Res. Commun. , vol.367 , pp. 406-412
    • Robb, E.L.1    Page, M.M.2    Wiens, B.E.3    Stuart, J.A.4
  • 14
    • 48749085399 scopus 로고    scopus 로고
    • Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
    • Rubiolo JA, Mithieux G, Vega FV. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol 2008; 591: 66-72.
    • (2008) Eur. J. Pharmacol. , vol.591 , pp. 66-72
    • Rubiolo, J.A.1    Mithieux, G.2    Vega, F.V.3
  • 15
    • 2342544918 scopus 로고    scopus 로고
    • Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress
    • Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004; 11: 1135-1146.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1135-1146
    • Smith, A.R.1    Shenvi, S.V.2    Widlansky, M.3    Suh, J.H.4    Hagen, T.M.5
  • 16
    • 0035451601 scopus 로고    scopus 로고
    • Mechanism of clofibrate hepatotoxicity: Mitochondrial damage and oxidative stress in hepatocytes
    • Qu B, Li QT, Wong KP, Tan TM, Halliwell B. Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes. Free Radic Biol Med 2001; 31: 659-669.
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 659-669
    • Qu, B.1    Li, Q.T.2    Wong, K.P.3    Tan, T.M.4    Halliwell, B.5
  • 17
    • 26444505495 scopus 로고    scopus 로고
    • Vitamin C enters mitochondria via facilitative glucose transporter 1 Glut1 and confers mitochondrial protection against oxidative injury
    • Sagun KC, Carcamo JM, Golde DW. Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J 2005; 19: 1657-1667.
    • (2005) FASEB J. , vol.19 , pp. 1657-1667
    • Sagun, K.C.1    Carcamo, J.M.2    Golde, D.W.3
  • 18
    • 0242489050 scopus 로고    scopus 로고
    • In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain
    • Zhang S, Fu J, Zhou Z. In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. Toxicol In Vitro 2004; 18: 71-77.
    • (2004) Toxicol In Vitro , vol.18 , pp. 71-77
    • Zhang, S.1    Fu, J.2    Zhou, Z.3
  • 19
    • 0037212601 scopus 로고    scopus 로고
    • Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate
    • Morkunaite-Haimi S, Kruglov AG, Teplova VV et al. Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate. Biochem Pharmacol 2003; 65: 43-49.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 43-49
    • Morkunaite-Haimi, S.1    Kruglov, A.G.2    Teplova, V.V.3
  • 20
    • 66949180856 scopus 로고    scopus 로고
    • Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells
    • Lee BW, Kwon SJ, Chae HY et al. Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells. Free Radic Res 2009; 43: 68-77.
    • (2009) Free Radic. Res. , vol.43 , pp. 68-77
    • Lee, B.W.1    Kwon, S.J.2    Chae, H.Y.3
  • 21
    • 54049145855 scopus 로고    scopus 로고
    • Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species
    • Rubiolo JA, Vega FV. Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species. Biomed Pharmacother 2008; 62: 606-612.
    • (2008) Biomed. Pharmacother. , vol.62 , pp. 606-612
    • Rubiolo, J.A.1    Vega, F.V.2
  • 23
    • 33746752252 scopus 로고    scopus 로고
    • Reduction in energy efficiency induced by expression of the uncoupling protein UCP1 in mouse liver mitochondria
    • Gonzalez-Muniesa P, Milagro FI, Campion J, Martinez JA. Reduction in energy efficiency induced by expression of the uncoupling protein, UCP1, in mouse liver mitochondria. Int J Mol Med 2006; 17: 591-597.
    • (2006) Int. J. Mol. Med. , vol.17 , pp. 591-597
    • Gonzalez-Muniesa, P.1    Milagro, F.I.2    Campion, J.3    Martinez, J.A.4
  • 24
    • 0033584437 scopus 로고    scopus 로고
    • Biochemical characterization of lucigenin bis-N-methylacridinium as a chemiluminescent probe for detecting intramitochondrial superoxide anion radical production
    • Li Y, Stansbury KH, Zhu H, Trush MA. Biochemical characterization of lucigenin (bis-N-methylacridinium) as a chemiluminescent probe for detecting intramitochondrial superoxide anion radical production. Biochem Biophys Res Commun 1999; 262: 80-87.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 80-87
    • Li, Y.1    Stansbury, K.H.2    Zhu, H.3    Trush, M.A.4
  • 25
    • 0033041561 scopus 로고    scopus 로고
    • Detection of mitochondria-derived reactive oxygen species production by the chemilumigenic probes lucigenin and luminol
    • Li Y, Zhu H, Trush MA. Detection of mitochondria-derived reactive oxygen species production by the chemilumigenic probes lucigenin and luminol. Biochim Biophys Acta 1999; 1428: 1-12.
    • (1999) Biochim. Biophys. Acta. , vol.1428 , pp. 1-12
    • Li, Y.1    Zhu, H.2    Trush, M.A.3
  • 26
    • 0031554917 scopus 로고    scopus 로고
    • Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3-1- phenylamino-carbonyl-34-tetrazolium-bis 4-methoxy-6- nitro benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase
    • Ukeda H, Maeda S, Ishii T, SawamuraM. Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3'-1- (phenylamino)-carbonyl-3,4- tetrazolium]-bis(4-methoxy-6- nitro)benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase. Anal Biochem 1997; 251: 206-209.
    • (1997) Anal. Biochem. , vol.251 , pp. 206-209
    • Ukeda, H.1    Maeda, S.2    Ishii, T.3    Sawamura, M.4
  • 27
    • 77957003282 scopus 로고
    • Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios
    • Estabrook R. Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 1967; 10: 41-47.
    • (1967) Methods Enzymol. , vol.10 , pp. 41-47
    • Estabrook, R.1
  • 28
    • 11144263646 scopus 로고    scopus 로고
    • P/O ratios of mitochondrial oxidative phosphorylation
    • Hinkle PC. P/O ratios of mitochondrial oxidative phosphorylation. Biochim Biophys Acta 2005; 1706: 1-11.
    • (2005) Biochim. Biophys. Acta. , vol.1706 , pp. 1-11
    • Hinkle, P.C.1
  • 29
    • 4544328685 scopus 로고    scopus 로고
    • Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment
    • Roussel D, Dumas JF, Simard G, Malthiery Y, Ritz P. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment. Biochem J 2004; 382: 491-499
    • (2004) Biochem. J. , vol.382 , pp. 491-499
    • Roussel, D.1    Dumas, J.F.2    Simard, G.3    Malthiery, Y.4    Ritz, P.5
  • 31
    • 65549141156 scopus 로고    scopus 로고
    • Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium
    • Oxford
    • Wilson JX. Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. BioFactors (Oxford) 2009; 35: 5-13.
    • (2009) Bio. Factors , vol.35 , pp. 5-13
    • Wilson, J.X.1
  • 32
    • 3042587904 scopus 로고    scopus 로고
    • Vitamin C and vitamin E in prevention of nonalcoholic fatty liver disease NAFLD in choline deficient diet fed rats
    • Oliveira CP, Gayotto LC, Tatai C et al. Vitamin C and vitamin E in prevention of nonalcoholic fatty liver disease (NAFLD) in choline deficient diet fed rats. Nutr J 2003; 2: 9.
    • (2003) Nutr. J. , vol.2 , pp. 9
    • Oliveira, C.P.1    Gayotto, L.C.2    Tatai, C.3
  • 33
    • 33947166239 scopus 로고    scopus 로고
    • Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: Protective effects of vitamin E vitamin C and carnitine
    • Devi SA, Vani R, Subramanyam MV, Reddy SS, Jeevaratnam K. Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: protective effects of vitamin E, vitamin C, and carnitine. Cell Biochem Funct 2007; 25: 221-231.
    • (2007) Cell. Biochem. Funct. , vol.25 , pp. 221-231
    • Devi, S.A.1    Vani, R.2    Subramanyam, M.V.3    Reddy, S.S.4    Jeevaratnam, K.5
  • 34
    • 33747807016 scopus 로고    scopus 로고
    • Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats
    • Ahn T, Yun CH, Oh DB. Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicol Lett 2006; 166: 27-36.
    • (2006) Toxicol. Lett. , vol.166 , pp. 27-36
    • Ahn, T.1    Yun, C.H.2    Oh, D.B.3
  • 35
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
    • Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 134: 707-716.
    • (1973) Biochem. J. , vol.134 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 36
    • 54249118108 scopus 로고    scopus 로고
    • Vitamin C supplementation influences body fat mass and steroidogenesisrelated genes when fed a high-fat diet
    • Campion J, Milagro FI, Fernandez D, Martinez JA. Vitamin C supplementation influences body fat mass and steroidogenesisrelated genes when fed a high-fat diet. Int J Vitam Nutr Res 2008; 78: 87-95.
    • (2008) Int. J. Vitam. Nutr. Res. , vol.78 , pp. 87-95
    • Campion, J.1    Milagro, F.I.2    Fernandez, D.3    Martinez, J.A.4
  • 37
    • 70350337093 scopus 로고    scopus 로고
    • Vitamin C: Update on physiology and pharmacology
    • Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009; 157: 1097-1110.
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 1097-1110
    • Mandl, J.1    Szarka, A.2    Banhegyi, G.3
  • 38
    • 0037081748 scopus 로고    scopus 로고
    • Ascorbic acid: Much more than just an antioxidant
    • Arrigoni O, De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta 2002; 1569: 1-9.
    • (2002) Biochim. Biophys. Acta. , vol.1569 , pp. 1-9
    • Arrigoni, O.1    De Tullio, M.C.2
  • 39
    • 33749990899 scopus 로고    scopus 로고
    • Ferulic acid with ascorbic acid synergistically extenuates the mitochondrial dysfunction during beta-adrenergic catecholamine induced cardiotoxicity in rats
    • Yogeeta SK, Raghavendran HR, Gnanapragasam A, Subhashini R, Devaki T. Ferulic acid with ascorbic acid synergistically extenuates the mitochondrial dysfunction during beta-adrenergic catecholamine induced cardiotoxicity in rats. Chem Biol Interact 2006; 163: 160-169.
    • (2006) Chem. Biol. Interact. , vol.163 , pp. 160-169
    • Yogeeta, S.K.1    Raghavendran, H.R.2    Gnanapragasam, A.3    Subhashini, R.4    Devaki, T.5
  • 40
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127: 1109-1122.
    • (2006) Cell. , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 41
    • 40749120875 scopus 로고    scopus 로고
    • Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: Role of phase 2 enzyme induction
    • Lu C, Bambang IF, Armstrong JS, Whiteman M. Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction? Diabetes Obes Metab 2008; 10: 347-349.
    • (2008) Diabetes Obes Metab. , vol.10 , pp. 347-349
    • Lu, C.1    Bambang, I.F.2    Armstrong, J.S.3    Whiteman, M.4
  • 43
    • 52749094256 scopus 로고    scopus 로고
    • Resveratrol inhibits nonalcoholic fatty liver disease in rats
    • Bujanda L, Hijona E, Larzabal M et al. Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol 2008; 8: 40.
    • (2008) BMC Gastroenterol. , vol.8 , pp. 40
    • Bujanda, L.1    Hijona, E.2    Larzabal, M.3
  • 45
    • 46949087413 scopus 로고    scopus 로고
    • Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid
    • ShenW, Liu K, Tian C et al. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J Cell Biochem 2008; 104: 1232-1243.
    • (2008) J. Cell. Biochem. , vol.104 , pp. 1232-1243
    • Shen, W.1    Liu, K.2    Tian, C.3
  • 46
    • 62349088898 scopus 로고    scopus 로고
    • Mitochondrial decay in the brains of old rats: Ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine
    • Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 2009; 34: 755-763.
    • (2009) Neurochem. Res. , vol.34 , pp. 755-763
    • Long, J.1    Gao, F.2    Tong, L.3    Cotman, C.W.4    Ames, B.N.5    Liu, J.6
  • 47
    • 0029006347 scopus 로고
    • Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria
    • Schonheit K, Gille L, Nohl H. Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. Biochim Biophys Acta 1995; 1271: 335-342.
    • (1995) Biochim. Biophys. Acta. , vol.1271 , pp. 335-342
    • Schonheit, K.1    Gille, L.2    Nohl, H.3
  • 48
    • 0031026392 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial systems for NADH- and NADPHdependent reduction of alpha-lipoic acid
    • Haramaki N, Han D, Handelman GJ, Tritschler HJ, Packer L. Cytosolic and mitochondrial systems for NADH- and NADPHdependent reduction of alpha-lipoic acid. Free Radic Biol Med 1997; 22: 535-542.
    • (1997) Free Radic. Biol. Med. , vol.22 , pp. 535-542
    • Haramaki, N.1    Han, D.2    Handelman, G.J.3    Tritschler, H.J.4    Packer, L.5
  • 49
    • 27744445808 scopus 로고    scopus 로고
    • Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid
    • Cakatay U. Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid. Med Hypotheses 2006; 66: 110-117.
    • (2006) Med. Hypotheses , vol.66 , pp. 110-117
    • Cakatay, U.1
  • 50
    • 0036790109 scopus 로고    scopus 로고
    • Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria
    • Dicter N, Madar Z, Tirosh O. Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria. J Nutr 2002; 132: 3001-3006.
    • (2002) J. Nutr. , vol.132 , pp. 3001-3006
    • Dicter, N.1    Madar, Z.2    Tirosh, O.3
  • 51
    • 0034119440 scopus 로고    scopus 로고
    • Mechanism of dihydrolipoate stimulation of the mitochondrial permeability transition: Effect of different respiratory substrates
    • Morkunaite S, Teplova VV, Saris NE. Mechanism of dihydrolipoate stimulation of the mitochondrial permeability transition: effect of different respiratory substrates. IUBMB Life 2000; 49: 211-216.
    • (2000) IUBMB Life , vol.49 , pp. 211-216
    • Morkunaite, S.1    Teplova, V.V.2    Saris, N.E.3


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