Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats

Chemico-Biological Interactions

Volumn 205, Issue 2, 2013, Pages 108-118

  Fujii, Yuta ^a   Segawa, Risa ^a   Kimura, Masayuki ^a   Wang, Liyun ^a   Ishii, Yuji ^b   Yamamoto, Ryuichi ^a   Morita, Reiko ^a,c   Mitsumori, Kunitoshi ^a,d   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d Food Safety Commission of Japan   (Japan)

Author keywords

Lipoic acid (a LA); Apoptosis; Death receptor 5 (DR5); Inflammation; Liver tumor promotion; Thioacetamide (TAA)

Indexed keywords

CASPASE 8; CASPASE 9; CYCLINE; CYCLOOXYGENASE 2; DEATH RECEPTOR 5; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; THIOACETAMIDE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CANCER STAGING; CD3+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EXPERIMENTAL RAT; IMMUNOLOCALIZATION; INFLAMMATORY CELL; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UPREGULATION;

Α-LIPOIC ACID; Α-LIPOIC ACID (A-LA); Β-NAPHTHOFLAVONE; 8-HYDROXYDEOXYGUANOSINE; 8-OHDG; A-LA; ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A1; ALDH1A1; APOPTOSIS; B-CELL CLL/LYMPHOMA 2; BAX; BCL2; BCL2-ASSOCIATED X PROTEIN; BCL2-LIKE 1; BCL2L1; BNF; CASP; CASPASE; CD4; CD4 MOLECULE; CD8A; CD8A MOLECULE; CHEMOKINE (C-X-C MOTIF) LIGAND 10; CHEMOKINE (C-X3-C MOTIF) LIGAND 1; CHOLINE-METHIONINE-DEFICIENT DIET; CMD; COL1A1; COLLAGEN, TYPE I, ALPHA 1; COPPER; COX-2; CU; CX3CL1; CXCL10; CYCLOOXYGENASE 2; DAB; DEATH RECEPTOR 5; DEATH RECEPTOR 5 (DR5); DEN; DIAMINOBENZIDINE; DR5; EMIQ; ENZYMATICALLY MODIFIED ISOQUERCITRIN; FADD; FAS (TNFRSF6)-ASSOCIATED VIA DEATH DOMAIN; FE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE S-TRANSFERASE MU 1; GLUTATHIONE S-TRANSFERASE PLACENTAL FORM; GPX2; GST-P; GSTM1; HEME OXYGENASE-1; HO-1; HPRT; HYPOXANTHINE GUANINE PHOSPHORIBOSYL TRANSFERASE; IL1B; IL4; INFLAMMATION; INTERLEUKIN 1 BETA; INTERLEUKIN 4; IRON; LIVER TUMOR PROMOTION; MAPK; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MMP; N-DIETHYLNITROSAMINE; NAD(P)H DEHYDROGENASE, QUINONE 1; NFE2L2; NQO1; NUCLEAR FACTOR, ERYTHROID DERIVED 2, LIKE 2; PBS; PCNA; PHOSPHATE BUFFERED SOLUTION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2; PTGS2; REACTIVE OXYGEN SPECIES; ROS; SERINE (OR CYSTEINE) PEPTIDASE INHIBITOR, CLADE E, MEMBER 1; SERPINE1; TAA; TBARS; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-MEDIATED NICK END LABELING; TGFB2; THIOACETAMIDE; THIOACETAMIDE (TAA); THIOBARBITURIC ACID-REACTIVE SUBSTANCES; THIOREDOXIN 1; TNF; TNFRSF10B; TNFSF10; TRAIL; TRANSFORMING GROWTH FACTOR, BETA 2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY, MEMBER 10; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 10B; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND; TUNEL; TXN1;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CARCINOGENS; COCARCINOGENESIS; DEOXYGUANOSINE; DIETHYLNITROSAMINE; GLUTATHIONE S-TRANSFERASE PI; INFLAMMATION MEDIATORS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MACROPHAGES; MALE; RATS; RATS, INBRED F344; THIOACETAMIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOCTIC ACID;

EID: 84884680201     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.06.017     Document Type: Article

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