Cytoplasmic STAT4 promotes antiviral type i IFN production by blocking CHIP-mediated degradation of RIG-I

Journal of Immunology

Volumn 196, Issue 3, 2016, Pages 1209-1217

  Zhao, Kai ^a   Zhang, Qian ^a,b   Li, Xia ^a   Zhao, Dezhi ^a   Liu, Yiqi ^c   Shen, Qicong ^b   Yang, Mingjin ^a,c   Wang, Chunmei ^a   Li, Nan ^b   Cao, Xuetao ^a,b,c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON; LIGASE; PROTEIN CHIP; RETINOIC ACID INDUCIBLE PROTEIN I; STAT4 PROTEIN; UNCLASSIFIED DRUG; CHIP PROTEIN, MOUSE; DDX58 PROTEIN, MOUSE; DEAD BOX PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CONFOCAL MICROSCOPY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; PERITONEUM MACROPHAGE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA VIRUS INFECTION; VIROLOGY;

ANIMALS; CYTOPLASM; DEAD-BOX RNA HELICASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOPRECIPITATION; INTERFERON TYPE I; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA VIRUS INFECTIONS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84957648478     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1501224     Document Type: Article

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