Reciprocal effects of IFN-β and IL-12 on STAT4 activation and cytokine induction in T cells

Journal of Leukocyte Biology

Volumn 81, Issue 6, 2007, Pages 1562-1567

  Fahey, Angela J ^a   Robins, R Adrian ^a   Constantinescu, Cris S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Human; IFN gamma; Interleukin 10; Signal transduction

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 12; NEUROGENIC DIFFERENTIATION FACTOR; STAT4 PROTEIN;

ARTICLE; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; INTERFERON TYPE I, RECOMBINANT; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-12; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR;

EID: 34249719985     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1006633     Document Type: Article

References (34)

1. Trinchieri, G. (1998) Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70, 83-243.
2. Schmitt, E., Hoehn, P., Huels, C., Goedert, S., Palm, N., Rude, E., Germann, T. (1994) T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β. Eur. J. Immunol. 24, 793-798.
3. Trinchieri, G., Pflanz, S., Kastelein, R. A. (2003) The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19, 641-644.
4. Bacon, C. M., Petricoin III, E. F., Ortaldo, J. R., Rees, R. C., Larner, A. C., Johnston, J. A., O'Shea, J. J. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92, 7307-7311.
5. Mu, J., Zou, J. P., Yamamoto, N., Tsutsui, T., Tai, X. G., Kobayashi, M., Herrmann, S., Fujiwara, H., Hamaoka, T. (1995) Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res. 55, 4404-4408.
6. Rodolfo, M., Colombo, M. P. (1999) Interleukin-12 as an adjuvant for cancer immunotherapy. Methods 19, 114-120.
7. O'Shea, J. J., Visconti, R. (2000) Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat. Immunol. 1, 17-19.
8. Rep, M. H., Schrijver, H. M., van Lopik, T., Hintzen, R. Q., Roos, M. T., Ader, H. J., Polman, C. H., van Lier, R. A. (1999) Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients. J. Neuroimmunol. 96, 92-100.
9. Mosmann, T. R., Moore, K. W. (1991) The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol. Today 12, A49-A53.
10. Howard, M., O'Garra, A. (1992) Biological properties of interleukin 10. Immunol. Today 13, 198-200.
11. Karp, C. L., Biron, C. A., Irani, D. N. (2000) Interferon β in multiple sclerosis: is IL-12 suppression the key? Immunol. Today 21, 24-28.
12. Wandinger, K. P., Sturzebecher, C. S., Bielekova, B., Detore, G., Rosenwald, A., Staudt, L. M., McFarland, H. F., Martin, R. (2001) Complex immunomodulatory effects of interferon-β in multiple sclerosis include the upregulation of T helper 1-associated marker genes. Ann. Neurol. 50, 349-357.
13. Sharp, P. A. (2001) RNA interference - 2001. Genes Dev. 15, 485-490.
14. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U., Sinigaglia, F. (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185, 825-831.
15. Fahey, A. J., Robins, R. A., Kindle, K. B., Heery, D. M., Constantinescu, C. S. (2006) Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent. J. Leukoc. Biol. 80, 133-144.
16. Hammond, S. M., Caudy, A. A., Hannon, G. J. (2001) Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2, 110-119.
17. Furlan, R., Bergami, A., Lang, R., Brambilla, E., Franciotta, D., Martinelli, V., Comi, G., Panina, P., Martino, G. (2000) Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4. J. Neuroimmunol. 111, 86-92.
18. Segal, B. M., Dwyer, B. K., Shevach, E. M. (1998) An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187, 537-546.
19. Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
20. Biron, C. A. (2001) Interferons α and β as immune regulators - a new look. Immunity 14, 661-664.
21. Drulovic, J., Mostarica-Stojkovic, M., Levic, Z., Mesaros, S., Stojsavljevic, N., Popadic, D., Pravica, V. (1998) Serum interleukin-12 levels in patients with multiple sclerosis. Neurosci. Lett. 251, 129-132.
22. Nguyen, K. B., Watford, W. T., Salomon, R., Hofmann, S. R., Pien, G. C., Morinobu, A., Gadina, M., O'Shea, J. J., Biron, C. A. (2002) Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science 297, 2063-2066.
23. Carter, L. L., Murphy, K. M. (1999) Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon γ production from CD4(+) versus CD8(+) T cells. J. Exp. Med. 189, 1355-1360.
24. Cousens, L. P., Orange, J. S., Su, H. C., Biron, C. A. (1997) Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94, 634-639.
25. Adorini, L. (2003) Cytokine-based immunointervention in the treatment of autoimmune diseases. Clin. Exp. Immunol. 132, 185-192.
26. Moore, K. W., de Waal Malefyt, R., Coffman, R. L., O'Garra, A. (2001) Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765.
27. Van Weyenbergh, J., P. Silva, M. P., Bafica, A., Cardoso, S., Wietzerbin, J., Barral-Netto, M. (2001) IFN-β and TGF-β differentially regulate IL-12 activity in human peripheral blood mononuclear cells. Immunol. Lett. 75, 117-122.
28. Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C. Y., Gately, M. K., Gubler, U. (1996) A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93, 14002-14007.
29. Rogge, L., D'Ambrosio, D., Biffi, M., Penna, G., Minetti, L. J., Presky, D. H., Adorini, L., Sinigaglia, F. (1998) The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161, 6567-6574.
30. Ziegler-Heitbrock, L., Lotzerich, M., Schaefer, A., Werner, T., Frankenberger, M., Benkhart, E. (2003) IFN-α induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J. Immunol. 171, 285-290.
31. Van Seventer, J. M., Nagai, T., van Seventer, G. A. (2002) Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J. Neuroimmunol. 133, 60-71.
32. Comabella, M., Balashov, K., Issazadeh, S., Smith, D., Weiner, H. L., Khoury, S. J. (1998) Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J. Clin. Invest. 102, 671-678.
33. Balashov, K. E., Comabella, M., Ohashi, T., Khoury, S. J., Weiner, H. L. (2000) Defective regulation of IFNγ and IL-12 by endogenous IL-10 in progressive MS. Neurology 55, 192-198.
34. Compston, A., Coles, A. (2002) Multiple sclerosis. Lancet 359, 1221-1231.