Ubiquitin on Ras: Warden or partner in crime?

Science Signaling

Volumn 4, Issue 163, 2011, Pages

  Pfleger, Cathie M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; UBIQUITIN;

CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; EXTRACELLULAR SPACE; GENE MUTATION; GERM LINE; HUMAN; MOLECULAR MECHANICS; NEOPLASM; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SOMATIC CELL; UBIQUITINATION; ANIMAL; BIOLOGICAL MODEL; METABOLISM; PHYSIOLOGY;

ANIMALS; HUMANS; MODELS, BIOLOGICAL; RAS PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION;

EID: 79952563237     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001874     Document Type: Review

References (25)

1. W. E. Tidyman, K. A. Rauen, The RASopathies: Developmental syndromes of Ras/MAPK pathway dysregulation. Curr. Opin. Genet. Dev. 19, 230-236 (2009).
2. B. D. Gelb, M. Tartaglia, Noonan syndrome and related disorders: Dysregulated RAS-mitogen activated protein kinase signal transduction. Hum. Mol. Genet. 15, R220-R226 (2006).
3. A. Young, J. Lyons, A. L. Miller, V. T. Phan, I. R. Alarcón, F. McCormick, Ras signaling and therapies. Adv. Cancer Res. 102, 1-17 (2009).
4. A. M. Duursma, R. Agami, Ras interference as cancer therapy. Semin. Cancer Biol. 13, 267-273 (2003).
5. D. Vigil, J. Cherfils, K. L. Rossman, C. J. Der, Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10, 842-857 (2010).
6. A. Mor, M. R. Philips, Compartmentalized Ras/MAPK signaling. Annu. Rev. Immunol. 24, 771-800 (2006).
7. N. Fehrenbacher, D. Bar-Sagi, M. Philips, Ras/MAPK signaling from endomembranes. Mol. Oncol. 3, 297-307 (2009).
8. J. Omerovic, I. A. Prior, Compartmentalized signalling: Ras proteins and signalling nanoclusters. FEBS J. 276, 1817-1825 (2009).
9. J. Omerovic, A. J. Laude, I. A. Prior, Ras proteins: Paradigms for compartmentalised and isoform-specific signalling. Cell. Mol. Life Sci. 64, 2575-2589 (2007).
10. J. R. Silvius, Mechanisms of Ras protein targeting in mammalian cells. J. Membr. Biol. 190, 83-92 (2002).
11. V. T. H. B. M. Smit, A. J. M. Boot, A. M. M. Smits, G. J. Fleuren, C. J. Cornelisse, J. L. Bos, KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res. 16, 7773-7782 (1988).
12. E. Rozenblum, M. Schutte, M. Goggins, S. A. Hahn, S. Panzer, M. Zahurak, S. N. Goodman, T. A. Sohn, R. H. Hruban, C. J. Yeo, S. E. Kern, Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57, 1731-1734 (1997).
13. N. Bardeesy, R. A. DePinho, Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2, 897-909 (2002).
14. C. J. Farr, R. K. Saiki, H. A. Erlich, F. McCormick, C. J. Marshall, Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc. Natl. Acad. Sci. U.S.A. 85, 1629-1633 (1988).
15. B. Vogelstein, C. I. Civin, A. C. Preisinger, J. P. Krischer, P. Steuber, Y. Ravindranath, H. Weinstein, P. Elfferich, J. Bos, RAS gene mutations in childhood acute myeloid leukemia: A Pediatric Oncology Group study. Genes Chromosomes Cancer 2, 159-162 (1990).
16. J. Reifenberger, C. B. Knobbe, A. A. Sterzinger, B. Blaschke, K. W. Schulte, T. Ruzicka, G. Reifenberger, Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. Int. J. Cancer 109, 377-384 (2004).
17. T. Whitwam, M. W. Vanbrocklin, M. E. Russo, P. T. Haak, D. Bilgili, J. H. Resau, H. M. Koo, S. L. Holmen, Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene 26, 4563-4570 (2007).
18. K. V. Visvanathan, R. D. Pocock, I. C. Summerhayes, Preferential and novel activation of H-ras in human bladder carcinomas. Oncogene Res. 3, 77-86 (1988).
19. S. E. Kim, J. Y. Yoon, W. J. Jeong, S. H. Jeon, Y. Park, J. B. Yoon, Y. N. Park, H. Kim, K. Y. Choi, H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation. J. Cell Sci. 122, 842-848 (2009).
20. H. Yan, M.-L. Chin, E. A. Horvath, E. A. Kane, C. M. Pfleger, Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo. J. Cell Sci. 122, 1461-1470 (2009).
21. N. Jura, E. Scotto-Lavino, A. Sobczyk, D. Bar- Sagi, Differential modification of Ras proteins by ubiquitination. Mol. Cell 21, 679-687 (2006).
22. H. Yan, M. Jahanshahi, E. A. Horvath, H. Y. Liu, C. M. Pfleger, Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila. Curr. Biol. 20, 1378-1382 (2010).
23. L. Xu, V. Lubkov, L. J. Taylor, D. Bar-Sagi, Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr. Biol. 20, 1372-1377 (2010).
24. J. Colicelli, Signal transduction: RABGEF1 fingers RAS for ubiquitination. Curr. Biol. 20, R630-R632 (2010).
25. A. T. Sasaki, A. Carracedo, J. W. Locasale, D. Anastasiou, K. Takeuchi, E. R. Kahoud, S. Haviv, J. M. Asara, P. P. Pandolfi, L. C. Cantley, Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci. Signal. 4, ra13 (2011).