Genetic Correlates of Gene Expression in Recombinant Inbred Strains: A Relational Model System to Explore Neurobehavioral Phenotypes

Neuroinformatics

Volumn 1, Issue 4, 2003, Pages 343-357

  Chesler, Elissa J ^a   Wang, Jintao ^b   Lu, Lu ^a   Qu, Yanhua ^a   Manly, Kenneth F ^b   Williams, Robert W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Behavioral genetics; Genetic correlation analysis; Oligonucleotide microarray; QTL mapping; Recombinant inbred mice; Relational databases

Indexed keywords

DNA; OLIGONUCLEOTIDE; RNA;

ANIMAL BEHAVIOR; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENETIC RECOMBINATION; GENOTYPE; INBRED STRAIN; MODEL; MOUSE; NEUROSCIENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CHROMOSOME MAPPING; DATABASES, GENETIC; FEMALE; GENE EXPRESSION; GENOME; MICE; MICE, INBRED STRAINS; MODELS, GENETIC; NEUROSCIENCES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RECOMBINATION, GENETIC; REVIEW LITERATURE; RNA, MESSENGER; STATISTICS;

EID: 0242353110     PISSN: 15392791     EISSN: None     Source Type: Journal    
DOI: 10.1385/NI:1:4:343     Document Type: Article

References (28)

1. Airey, D. C., Lu, L., Williams, R. W. (2001) Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. J. Neurosci. 21, 5099-5109.
2. Beach, T. G., Woodhurst, W. B., MacDonald, D. B., Jones, M. W. (1995) Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci. Lett. 191, 27-30.
3. Belknap, J. K. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behav. Genet. 28, 29-38.
4. Buck, K. J., Metten, P., Belknap, J. K., Crabbe, J. C. (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci. 17, 3946-3955.
5. Chesler, E. J., Wilson, S. G., Lariviere, W. R., Rodriguez-Zas, S. L., Mogil, J. S. (2002a) Influences of laboratory environment on behavior. Nat. Neurosci. 5, 1101-1102.
6. Chesler, E. J., Wilson, S. G., Lariviere, W. R., Rodriguez-Zas, S. L., Mogil, J. S. (2002b) Indentification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large datta archive. Neurosci. Biohav. Rev. 26, 907-923.
7. Chesler, E. J., Rodriguez-Zas, S. L., Mogil, J. S. (2001) In silico mapping of mouse quantitative trait loci. Science. 294, 2423.
8. Crabbe, J. C., Belknap, J. K., Buck, K. J., Metten, P. (1994) Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol. Suppl. 2, 67-71.
9. Crabbe, J. C., Kosobud, A., Young, E. R., Janowsky, J. S. (1983) Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains. Neurobehav. Toxicol. Teratol. 5, 181-187.
10. Crabbe, J. C., Wahlsten, D., Dudek, B. C. (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670-1672.
11. Darvasi, A. (2001) In silico mapping of mouse quantitative trait loci. Science 294, 2423.
12. Hain, H. S., Crabbe, J. C., Bergeson, S.E., Belknap, J. K. (2000) Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. J. Pharmacol. Exp. Ther. 293, 180-187.
13. Hamer, D. (2002) Genetics. Rethinking behavior genetics. Science 298, 71-72.
14. Hitzemann, R., Hitzemann, B., Rivera, S., et al. (2003) Dopamine D2 Receptor binding, Drd2 Expression and the number of dopamine neurons in the BXD recombinant inbred series: Genetic relationships to alcohol and other drug related phenotypes. Alc. Clin. Exp. Res. 27, 1-11.
15. Janowsky, A., Mah, C., Johnson, R. A., et al. (2001) Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. J. Pharmacol. Exp. Ther. 298, 634-643.
16. Kirstein, S.L., Davidson, K.L., Ehringer, M.A., Sikela, J.M., Erwin, V.G., Tabakoff, B. (2002) Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J. Pharmacol. Exp. Ther. 302, 1238-1245.
17. Le Roy, I., Roubertoux, P.L., Jamot, L., et al. (1998) Neuronal and behavioral differences between Mus musculus domesticus (C57BL/6JBy) and Mus musculus castaneus (CAST/Ei). Behav. Brain Res. 95, 135-142.
18. Neumann, P.E., Seyfried, T. N. (1990) Mapping of two genes that influence susceptibility to audio-genic seizures in crosses of C57BL/6J and DBA/2J mice. Behav. Genet. 20, 307-323.
19. Paigen, K., Eppig, J. T. (2000) A mouse phenome project. Mamm Genome. 11, 715-717.
20. Palmer A. A., Miller M. N., McKinnon C. S., Phillips T. J. (2002) Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behav. Neurosci. 116, 126-127.
21. Plomin, R., McClearn, G.E., Gora-Maslak, G., Neiderhiser, J.M. (1991) Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. Behav. Genet. 21, 99-116.
22. Roberts, A. J., Phillips, T. J., Belknap, J. K., Finn, D. A., Keith, L. D. (1995) Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice. Behav. Neurosci. 109, 1199-1208.
23. Threadgill, D. W., Hunter, K. W., Williams, R. W. (2002) Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm. Gen. 13, 175-178.
24. Vogel, G. (2003) Genetics. Scientists dream of 1001 complex mice. Science 301, 456-457.
25. Wang, J., Williams, R. W., and Manly, K. F. (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1, 299-308.
26. Williams, R. W., Gu, J., Qi, S., Lu, L. (2001a) The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol. 2, RESEARCH0046.
27. Williams, R. W., Airey, D. C., Kulkarni, A., Zhou, G., Lu, L. (2001b) Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size. Behav. Genet. 31, 61-77.
28. Wong, C. G, Scherer, S. W., Snead, O. C. 3rd, Hampson, D. R. (2001) Localization of the human mGluR4 gene within an epilepsy susceptibility locus(1). Brain Res. Mol. Brain Res. 87, 109-116.