Age- and Sex-Related Differences in Spontaneous Hemorrhage and Fibrosis of the Pancreatic Islets in Sprague–Dawley Rats

Toxicologic Pathology

Volumn 35, Issue 3, 2007, Pages 388-394

  Imaoka, Masako ^a   Satoh, Hiroshi ^a   Furuhama, Kazuhisa ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

fibrous segmentations; hemorrhage; Islet of Langerhans; spontaneous lesions; Sprague Dawley rats

Indexed keywords

COLLAGEN FIBER; ESTRADIOL; FERRIC FERROCYANIDE; INSULIN; IRON;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CAPILLARY; CELL STRUCTURE; CONTROLLED STUDY; CYSTIC FIBROSIS; DIET; ENDOTHELIUM CELL; ESTRADIOL BLOOD LEVEL; FEMALE; IMMUNOHISTOCHEMISTRY; INCIDENCE; LIPID DIET; MACROPHAGE MIGRATION; MALE; MORPHOLOGY; NONHUMAN; PANCREAS HEMORRHAGE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PIGMENTATION; PRIORITY JOURNAL; PROTECTION; PROTEIN DIET; RAT; SEROLOGY; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; STAINING; ULTRASTRUCTURE;

AGE FACTORS; AGING; ANIMALS; FEMALE; FIBROSIS; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; INCIDENCE; ISLETS OF LANGERHANS; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 33947415762     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230701230304     Document Type: Article

References (23)

1. Ahuja SK Manichavel V Amy RM Age-related qualitative and quantitative changes in the endocrine pancreas of the LA/N-corpulent rat Diabetes Res 1987 6 137 44
2. Arnal JF Bayard F Vasculoprotective effects of oestrogens Clin Exp Pharmacol Physiol 2001 28 1032 4
3. Boorman GA Hollander CF Spontaneous lesions in the female WAG-Rij (Wistar) rat J Gerontol 1973 28 152 9
4. Dillberger JE Age-related pancreatic islet changes in Sprague–Dawley rats Toxicol Pathol 1994 22 48 55
5. Furuhama K Onodera T A simple technique for repeated blood collection from the tail vein of the rat J Toxicol Sci 1983 8 161 3
6. Gomez Dumm CL Semino MC Gagliardino JJ Sequential morphological changes in pancreatic islets of spontaneously diabetic rats Pancreas 1990 5 533 9
7. Hajdu A Rona G Morphological observations on spontaneous pancreatic islet changes in rats Diabetes 1967 16 108 10
8. Hajdu A Rona G The protective effect of estrogens against spontaneous pancreatic islet and renal changes in aging male rats Experimentia 1971 27 956 7
9. Hajdu A Herr F Rona G The functional significance of a spontaneous pancreatic islet change in aged rats Diabetologia 1968 4 44 7
10. Japanese Association for Laboratory Animals Science Guidelines for animal experimentation Exp Anim 1987 36 285 8
11. Keenan KP Soper KA Hertzog PR Gumprecht LA Smith PF Mattson BA Ballam GC Clark RL Diet, overfeeding, and moderate dietary restriction in control Sprague–Dawley rats: II. Effects on age-related proliferative and degenerative lesions Toxicol Pathol 1995a 23 287 302
12. Keenan KP Soper KA Smith PF Mattson BA Ballam GC Clark RL Diet, overfeeding, and moderate dietary restriction in control Sprague–Dawley rats: I. Effects on age-related proliferative and degenerative lesions Toxicol Pathol 1995b 23 269 86
13. Larsson LI Boder GB Shaw WN Changes in the islets of Langerhans in the obese Zucker rat Lab Invest 1977 36 593 8
14. Majeed SK Studies of the incidence of spontaneous pancreatic tumors in ageing CD rats Arzneimittelforschung 1997 47 879 84
15. Masuyama T Komeda K Hara A Noda M Shinohara M Oikawa T Kanazawa Y Taniguchi K Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats Biochem Biophys Res Commun 2004 314 870 7
16. Molon-Noblot S Keenan KP Coleman JB Hoe CM Laroque P The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pancreatic islet pathology in Sprague–Dawley rats Toxicol Pathol 2001 29 353 62
17. Mori Y Yokoyama J Nishimura M Kurata H Miura J Ikeda Y Diabetic strain (WBN/Kob) of rat characterized by endocrine-exocrine pancreatic impairment due to distinct fibrosis Pancreas 1990 5 452 9
18. Nakama K Shichinohe K Kobayashi K Naito K Uchida O Yasuhara K Tobe M Spontaneous diabetes-like syndrome in WBN/Kob rats Acta Diabetol Lat 1985 22 335 42
19. Reaven EP Curry DL Reaven GM Effect of age and sex on rat endocrine pancreas Diabetes 1987 36 1397 400
20. Ruhe RC Curry DL Herrmann S McDonald RB Age and gender effects on insulin secretion and glucose sensitivity of the endocrine pancreas Am J Physiol 1992 262 R671 6
21. Schwertz DW Penckofer S Sex differences and the effects of sex hormones on hemostasis and vascular reactivity Heart Lung 2001 30 401 26
22. Shinohara M Oikawa T Sato K Effect of ovariectomy and estrogen treatment on diabetic pathogenesis in spontaneously diabetic Torii (SDT) rats Reprod Immunol Biol 2005 20 5 9
23. Spencer AJ Andreu M Greaves P Neoplasia and hyperplasia of pancreatic endocrine tissue in the rat: an immunocytochemical study Vet Pathol 1986 23 11 15