Morphology of pancreatic islets: A time course of pre-diabetes in Zucker fatty rats

Methods in Molecular Biology

Volumn 560, Issue , 2009, Pages 159-189

  Augstein, Petra ^a   Salzsieder, Eckhard ^a  

^a Institut fur Diabetes 'Gerhardt Katsch'   (Germany)

Author keywords

Diabetes mellitus; Glucagon; Immunofluorescence; Immunohistochemistry; Insulin; Morphology; Pancreatic islet; Zucker fatty rat

Indexed keywords

ANIMALIA; RATTUS;

ANIMAL; ARTICLE; CYTOLOGY; IMPAIRED GLUCOSE TOLERANCE; PANCREAS ISLET; PATHOLOGY; RAT; ZUCKER RAT;

ANIMALS; CYTOLOGICAL TECHNIQUES; ISLETS OF LANGERHANS; PREDIABETIC STATE; RATS; RATS, ZUCKER;

EID: 73349086564     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-448-3_12     Document Type: Article

References (27)

1. Weir G. C. , Laybutt D. R. , Kaneto H. , Bonner-Weir S. , and Sharma A. (2001). Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 50 Suppl 1 , S154-S159
2. Beck-Nielsen H. and Groop L. (1994). Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J. Clin. Invest. 94 , 1714-1721
3. Ferrannini E. (1998). Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects. Endocr. Rev 19 , 477-490
4. Ritzel R. A. , Butler A. E. , Rizza R. A. , Veldhuis J. D. , and Butler P. C. (2006). Relationship between â-cell mass and fasting blood glucose concentration in humans. Diabetes Care 29 , 717-718
5. Clark A. , Jones L. , de Koning E. , Hansen B. C. , and Matthews D. R. (2001). Decreased insulin secretion in type 2 diabetes: A problem of cellular mass or function? Diabetes 50 , S169-S171
6. Chan C. B. , Wright G. M. , Wadowska D. W. , MacPhail R. M. , Ireland W. P. , and Sulston K. W. (1998). Ultrastructural and secretory heterogeneity of fa/fa (Zucker) rat islets. Mol. Cell Endocrinol. 136 , 119-129
7. Finegood D. T. , McArthur M. D. , Kojwang D. , Thomas M. J. , Topp B. G. , Leonard T. et al. (2001). Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50 , 1021-1029
8. Tikellis C. , Wookey P. J. , Candido R. , Andrikopoulos S. , Thomas M. C. , and Cooper M. E. (2004). Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat. Diabetes 53 , 989-997
9. Schröder D. , Berg S. , Altmann S. , Lucke S. , Augstein P. , and Salzsieder E. (2006). Charakterisierung von Zucker fatty Ratten (fa/ fa)-Beziehung von Stoffwechselparametern, Glukosetoleranz und Eigenschaften isolierter Langerhansscher Inseln. Diabetologie und Stoffwechsel 1 , 64-A-132
10. Berthiaume N. , Mika A. K. , and Zinker B. A. (2003). Development of insulin resistance and endothelin-1 levels in the Zucker fatty rat. Metab. Clin. Exp. 52 , 845-849
11. Apweiler R. and Freud P. (1993). Development of glucose intolerance in obese (fa/fa) Zucker rats. Horm. Metab. Res. 25 , 521-524
12. Wargent E. , Stocker C. , Augstein P. , Heinke P. , Meyer A. , Hoffmann T. et al. (2005). Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: Comparison with and combination with rosiglitazone. Diabetes Obes. Metab. 7 , 170-181
13. Buckingham R. E. , al Barazanji K. A. , Toseland C. D. , Slaughter M. , Connor S. C. , West A. et al. (1998). Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes 47 , 1326-1334
14. Augstein P. , Schlosser M. , Ziegler B. , Hahmann J. , Mauch L. , and Ziegler M. (1996). Comparison of the islet cell antibody pattern of monoclonal glutamic acid decarboxylase antibodies recognizing linear and conformational epitopes. Acta Histochem. 98 , 229-241
15. Augstein P. , Elefanty A. G. , Allison J. , and Harrison L. C. (1998). Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 41 , 1381-1388
16. Romeis. Mikroskopische Technik. (17th ed) (1989). München; Wien; Baltimore: Urban ' Schwarzenberg
17. Hofman F. (2002). Immunohistochemistry. In: Current Protocols in Immunology. John Wiley & Sons, Inc. , New York , 21.4.1-21.4.23
18. Augstein P. , Braun B. , Ziegler B. , Woltanski K. P. , and Ziegler M. (1992). Characterization of two porcine proinsulin reactive monoclonal antibodies by immunostaining of beta-cells in pancreatic sections of different species. Acta Histochem. 93 , 433-440
19. Witt S. , Dietz H. , Ziegler B. , Keilacker H. , and Ziegler M. (1988). Production and use of monoclonal glucagon and insulin antibodies-reduction of pancreatic insulin in rats by treatment with complete Freund's adjuvant. Acta Histochem. Suppl 35 , 217-223
20. Hahn H. J. , Gerdes J. , Lucke S. , Liepe L. , Kauert C. , Volk H. D. et al. (1988). Phenotypical characterization of the cells invading pancreatic islets of diabetic BB/OK rats: Effect of interleukin 2 receptor-targeted immunotherapy. Eur. J. Immunol. 18 , 2037-2042
21. Lucke S. , Ziegler B. , Weidlich K. , Barowski U. , Besch W. , and Hahn H. J. (1985). The effects of subdiabetogenic streptozotocin doses on rat beta cell volume and functions. Biomed. Biochim. Acta 44 , 167-171
22. Weibel E. R. (1969). Stereological principles for morphometry in electron microscopic cytology. Int. Rev. Cytol. 26 , 235-302
23. Lucke S. (1987) Die Bedeutung der reduzierten â-Zellmasse für die Regeneration der insulinproduzierenden Zellen im Rattenpankreas. Dissertation 1-81. Ernst-Moritz-Arndt-Universitat-Greifswald
24. Kohnert K. D. , Ziegler B. , Falt K. , Odselius R. , Ziegler M. , and Falkmer S. (1987). Biochemical, immunohistochemical and ultrastructural studies of the alteration of pancreatic beta cells resulting from the combined effects of complete Freund's adjuvant and non-diabetogenic doses of streptozotocin. Exp. Clin. Endocrinol. 89 , 259-268
25. Lucke S. , Radloff E. , Laube R. , and Hahn H. J. (1991). Morphology of the endocrine pancreas in cyclosporine-treated glucose-intolerant Wistar rats. Anat. Anz. 172 , 351-358
26. Kohnert K. D. , Falt K. , Witt S. , Ziegler B. , and Ziegler M. (1988). Identification of monoclonal antibodies to pancreatic islet cells by immunoperoxidase staining. Acta Histochem. 83 , 159-165
27. Augstein P. , Braun B. , Ziegler B. , Woltanski K. P. , and Ziegler M. (1992). Characterization of two porcine proinsulin reactive monoclonal antibodies by immunostaining of beta-cells in pancreatic sections of different species. Acta Histochem. 93 , 433-440