Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases

ACS Chemical Biology

Volumn 6, Issue 4, 2011, Pages 325-335

  Pierrat, Olivier A ^a   Strisovsky, Kvido ^a   Christova, Yonka ^a   Large, Jonathan ^b   Ansell, Keith ^b   Bouloc, Nathalie ^b   Smiljanic, Ela ^b   Freeman, Matthew ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA LACTAM; CHYMOTRYPSIN; RHOMBOID PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; IC 50; MAMMAL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; COS CELLS; ESCHERICHIA COLI; FLUORESCENT DYES; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MONOBACTAMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT FUSION PROTEINS; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS; SMALL MOLECULE LIBRARIES; SPECIES SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 79954613090     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100314y     Document Type: Article

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