Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S′ subsites

Biochemistry

Volumn 51, Issue 18, 2012, Pages 3723-3731

  Xue, Yi ^a   Chowdhury, Somenath ^b   Liu, Xuying ^a,d   Akiyama, Yoshinori ^c   Ellman, Jonathan ^a,b   Ha, Ya ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c KYOTO UNIVERSITY   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CONFORMATIONAL FLEXIBILITY; COVALENTLY BONDED; ENZYME MECHANISM; HYDROPHOBIC ENVIRONMENT; MEMBRANE PROTEASE; POLYPEPTIDE BACKBONES; SIDE-CHAINS; SUBSITES; SUBSTRATE BINDING; TRANSMEMBRANE HELICES;

LIPID BILAYERS;

AMINO ACIDS;

PROTEINASE; RHOMBOID PROTEASE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; HYDROGEN BOND; LIPID BILAYER; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION;

ALANINE; BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEASE INHIBITORS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE;

EID: 84860711067     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300368b     Document Type: Article

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