Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate

Journal of Biological Chemistry

Volumn 287, Issue 5, 2012, Pages 3099-3107

  Xue, Yi ^a   Ha, Ya ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL FUNCTIONS; CATALYTIC MECHANISMS; CRYSTALLOGRAPHIC ANALYSIS; HYDROLYTIC REACTIONS; ISOCOUMARIN; MAIN CHAINS; MEMBRANE PROTEASE; OXYANIONS; SERINE PROTEASE; SIDE-CHAINS; STRUCTURAL DATA; SUBSTRATE-BINDING; TETRAHEDRAL INTERMEDIATES; TRANSMEMBRANE HELICES;

AMIDES; AMINO ACIDS; ENZYME ACTIVITY; PHOSPHORYLATION; POSITIVE IONS; REACTION INTERMEDIATES;

CRYSTAL STRUCTURE;

3,4 DICHLOROISOCOUMARIN; ASPARTIC ACID; ASPARTIC ACID 154; CHYMOTRYPSIN; DIISOPROPYL FLUOROPHOSPHATASE; GLUCAGON LIKE PEPTIDE 1; HISTIDINE; HISTIDINE 150; HISTIDINE 254; HISTONE; ISOCOUMARIN DERIVATIVE; MEMBRANE PROTEIN; PROTEINASE; SERINE; SERINE 201; SERINE PROTEINASE; TRYPTOPHAN; TRYPTOPHAN 236; TYROSINE; TYROSINE 205; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; PLASTICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE;

BACTERIAL PROTEINS; COUMARINS; CRYSTALLOGRAPHY, X-RAY; ISOFLUROPHATE; MODELS, MOLECULAR; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROVIDENCIA;

BACTERIA (MICROORGANISMS);

EID: 84856292019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.310482     Document Type: Article

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