Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2472-2477

  Vosyka, Oliver ^a   Vinothkumar, Kutti R ^b   Wolf, Eliane V ^a   Brouwer, Arwin J ^c   Liskamp, Rob M J ^c   Verhelst, Steven H L ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Covalent inhibition; MALDI screening; Regulated intramembrane proteolysis

Indexed keywords

PROTEINASE; RHOMBOID PROTEASE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; ESCHERICHIA COLI; MASS SPECTROMETRY; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

CLICK CHEMISTRY; CRYSTALLIZATION; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ESCHERICHIA COLI PROTEINS; ISOCOUMARINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR PROBES; MOLECULAR STRUCTURE; PROTEOLYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 84873742188     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215076110     Document Type: Article

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