Indications and contraindications for infusing specific amino acids (leucine, glutamine, arginine, citrulline, and taurine) in critical illness

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 19, Issue 2, 2016, Pages 161-169

  Ginguay, Antonin ^a   De Bandt, Jean Pascal ^a,b   Cynober, Luc ^a,b  

^a HÔTEL DIEU   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

amino acids; immune enhancing diets; multiple organ failure; septic shock

Indexed keywords

ARGININE; CITRULLINE; GLUTAMINE; LEUCINE; TAURINE;

CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIET SUPPLEMENTATION; HEART INJURY; HUMAN; META ANALYSIS (TOPIC); MICROCIRCULATION; MULTICENTER STUDY (TOPIC); MULTIPLE ORGAN FAILURE; MUSCLE DISEASE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPERFUSION INJURY; REVIEW; SEPSIS; SYSTEMATIC REVIEW (TOPIC); TREATMENT CONTRAINDICATION; TREATMENT INDICATION; DIETARY SUPPLEMENT; ENTERIC FEEDING; INTENSIVE CARE; INTENSIVE CARE UNIT; PARENTERAL NUTRITION;

ARGININE; CITRULLINE; CRITICAL CARE; CRITICAL ILLNESS; DIETARY SUPPLEMENTS; ENTERAL NUTRITION; GLUTAMINE; HUMANS; INTENSIVE CARE UNITS; LEUCINE; PARENTERAL NUTRITION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TAURINE;

EID: 84957435043     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000255     Document Type: Review

References (66)

1. Fremont RD, Rice TW. Pros and cons of feeding the septic intensive care unit patient. Nutr Clin Pract 2015; 30:344-350.
2. McClave SA, Martindale RG, Rice TW, Heyland DK. Feeding the critically ill patient. Crit Care Med 2014; 42:2600-2610.
3. van Zanten RH. Glutamine and antioxidants: status of their use in critical illness. Curr Opin Clin Nutr Metab Care 2015; 18:179-186.
4. Evans DC, Hegazi AA. Immunonutrition in critically ill patients: does one size fit all? J Parent Ent Nutr 2015; 39:500-501.
5. De Bandt JP, Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr 2006; 136 (Suppl):308S-313S.
6. Cynober L, De Bandt JP, Moinard C. Leucine and citrulline: two major regulators of protein turnover. World Rev Nutr Diet 2013; 105:97-105.
7. Laufenberg LJ, Pruznak AM, Navaratnarajah M, Lang CH. Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle. Amino Acids 2014; 6:2787-2798.
8. Dodd KM, Tee AR. Leucine and mTORC1: a complex relationship. Am J Physiol Endocrinol Metab 2012; 302:E1329-E1342.
9. Jewell JL, Russell RC,Guan KL. Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol 2013; 14:133-1399.
10. McIntire KL, Chen Y, Sood S, Rabkin R. Acute uremia suppresses leucineinduced signal transduction in skeletal muscle. Kidney Int 2014; 85:374-382.
11. De Bandt JP, Cynober LA. Amino acids with anabolic properties. Curr Opin Clin Nutr Metab Care 1998; 1:263-272.
12. Buijs N, Brinkmann SJ, Oosterink JE, et al. Intravenous glutamine supplementation enhances renal de novo arginine synthesis in humans: a stable isotope study. Am J Clin Nutr 2014; 100:1385-1391.
13. Nä geli M, Fasshauer M, Sommerfeld J, et al. Prolonged continuous intravenous infusion of the dipeptide L-alanine-L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury. Crit Care 2014; 18:R139.
14. Ekmark L, Rooyackers O, Wernerman J, Flä ring U. Plasma glutamine deficiency is associated with multiple organ failure in critically ill children. Amino Acids 2015; 47:535-542.
15. Singer P, Berger MM, Van den Berghe G, et al. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 2009; 28:387-400.
16. Cynober L, De Bandt JP. Glutamine in the intensive care unit. Curr Opin Clin Nutr Metab Care 2014; 17:98-104.
17. Andrews PJD, Avenell A, Noble DB, et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ 1542; 342.
18. Wernerman J, Kirketeig T, Andersson B, et al. Scandinavian glutamine trial: a pragmatic multicentre randomised clinical trial of intensive care unit patients. Acta Anaesthesiol Scand 2011; 55:812-818.
19. Heyland D, Muscedere J, Wischmeyer PE, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013; 368:1489-1497.
20. Wischmeyer PE, Dhaliwal R, McCall M, et al. Parenteral glutamine supplementation in critical illness: a systematic review. Crit Care 2014; 18:R76.
21. Tao KM, Li XQ, Yang LQ, et al. Glutamine supplementation for critically ill adults. Cochrane Database Syst Rev 2014; 9:CD010050.
22. Bollhalder L, Pfeil AM, Tomonaga Y, Schwenkglenks M. A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation. Clin Nutr 2013; 32:213-223.
23. Pradelli L, Povero M, Muscaritoli M, Eandi M. Updated cost-effectiveness analysis of supplemental glutamine for parenteral nutrition of intensive-care patients. Eur J Clin Nutr 2015; 69:546-551.
24. Dhaliwal R, Cahill N, Lemieux M, Heyland DK. The Canadian critical care nutrition guidelines in 2013: an update on current recommendations and implementation strategies. Nutr Clin Pract 2014; 29:29-43.
25. Grintescu IM, Vasiliu IL, Badica IC, et al. The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patients. A randomized-controlled clinical study. Clin Nutr 2015; 34:377-382.
26. Heyland DK, Elke G, Cook D, et al. Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. JPEN J Parenter Enteral Nutr 2015; 39:401-409.
27. Kao C, Hsu J, Bandi V, Jahoor F. Alterations in glutamine metabolism and its conversion to citrulline in sepsis. Am J Physiol Endocrinol Metab 2013; 304:E1359-E1364.
28. Cioccari L, Gautschi M, Etter R, et al. Further concerns about glutamine: a case report on hyperammonemic encephalopathy. Crit Care Med 2015. [Epub ahead of print]
29. Pé rez-Bárcena J, Marsé P, Zabalegui-Pé rez A, et al. A randomized trial of intravenous glutamine supplementation in trauma ICU patients. Intensive Care Med 2014; 40:539-547.
30. Jafari T, Feizi A, Askari G, Fallah AA. Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. Clin Nutr 2015; 34:35-43.
31. Lin JJ, Chung XJ, Yang CY, Lau HL. A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn. Burns 2013; 39:565-570.
32. Tan HB, Danilla S, Murray A, et al. Immunonutrition as an adjuvant therapy for burns. Cochrane Database Syst Rev 2014; 12:CD007174.
33. Moe-Byrne T, Wagner JV, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2012; 3:CD001457.
34. Jordan I, Balaguer M, Esteban ME, et al. Glutamine effects on heat shock protein 70 and interleukines 6 and 10: Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children. Clin Nutr 2015; doi: 101016/jclnu201501019 [Epub ahead of print]
35. Pierre JF, Heneghan AF, Lawson CM, et al. Pharmaconutrition review: physiological mechanisms. JPEN J Parenter Enteral Nutr 2013; 37:51S-65S.
36. Pekarova M, Lojek A. The crucial role of L-arginine in macrophage activation: what you need to know about it. Life Sci 2015; 137:44-48.
37. Wijnands KA, Castermans TMR, Hommen MPJ, et al. Arginine and citrulline and the immune response in sepsis. Nutrients 2015; 7:1426-1463.
38. Zhu X, Pribis JP, Rodriguez PC, et al. The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury. Ann Surg 2014; 259:171-178.
39. Tadié JM, Cynober L, Peigne V, et al. Arginine administration to critically ill patients with a low nitric oxide fraction in the airways: a pilot study. Intensive Care Med 2013; 39:1663-1665.
40. Quirino IE, Cardoso VN, Dos Santos RC, et al. The role of L-arginine and inducible nitric oxide synthase in intestinal permeability and bacterial translocation. JPEN J Parenter Enteral Nutr 2013; 37:392-400.
41. Bonhomme S, Belabed L, Blanc MC, et al. Arginine-supplemented enteral nutrition in critically ill diabetic and obese rats: a dose-ranging study evaluating nutritional status and macrophage function. Nutrition 2013; 29:305-312.
42. Breuillard C, Cynober L, Moinard C. Citrulline and nitrogen homeostasis: an overview. Amino Acids 2015; 47:685-691.
43. Qualls JE, Subramanian C, Rafi W, et al. Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell Host Microbe 2012; 12:313-323.
44. Crenn P, Neveux N, Chevret S, et al. COIITSS Study Group Plasma l-citrulline concentrations and its relationship with inflammation at the onset of septic shock: A pilot study. J Crit Care 2014; 29:315e1-315e6.
45. Ware LB, Magarik JA, Wickersham N, et al. Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis. Crit Care 2013; 17:R10.
46. Kietadisorn R, Juni RP, Moens AL. Tackling endothelial dysfunction by modulating NOS uncoupling: New insights into its pathogenesis and therapeutic possibilities. Am J Physiol Endocrinol Metab 2012; 302:E481-E495.
47. Wijnands KA, Vink H, Briedé JJ, et al. Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. PLOS One 2012; 7:e37439.
48. Grimaldi D, Guivarch E, Neveux N, et al. Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients. Resuscitation 2013; 84:60-65.
49. Fu X, Li S, Jia G, et al. Protective effect of the nitric oxide pathway in L-citrulline renal ischaemia-reperfusion injury in rats. Folia Biol (Praha) 2013; 59:225-232.
50. Moisey LL, Mourtzakis M, Cotton BA, et al. Nutrition and Rehabilitation Investigators Consortium (NUTRIC). Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care 2013; 17:R206.
51. Muscaritoli M, Lucia S, Molfino A. Sarcopenia in critically ill patients: the new pandemia. Minerva Anestesiol 2013; 79:771-777.
52. Faure C, Morio B, Chafey P, et al. Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats. Proteomics 2013; 13:2191-2201.
53. Ham DJ, Kennedy TL, Caldow MK, et al. Citrulline does not prevent skeletal muscle wasting or weakness in limb-casted mice. J Nutr 2015; 145:900-906.
54. Joffin N, Jaubert AM, Durant S, et al. Citrulline induces fatty acid release selectively in visceral adipose tissue from old rats. Mol Nutr Food Res 2014; 58:1765-1775.
55. Moinard C, Le Plenier S, Noirez P, et al. Citrulline supplementation induces changes in body composition and limits age-related metabolic changes in healthy male rats. J Nutr 2015; 145:1429-1437.
56. Marcinkiewicz J, Kontny E. Taurine and inflammatory diseases. Amino Acids 2014; 46:7-20.
57. Kim C, Cha YN. Taurine chloramine produced from taurine under inflammation provides anti-inflammatory and cytoprotective effects. Amino Acids 2014; 46:89-100.
58. Froger N, Moutsimilli L, Cadetti L, et al. Taurine: the comeback of a neutraceutical in the prevention of retinal degenerations. Prog Retin Eye Res 2014; 41:44-63.
59. Su L, Li H, Xie A, et al. Dynamic changes in amino acid concentration profiles in patients with sepsis. PLoS One 2015; 10:e0121933.
60. Vermeulen MA, van Stijn MF, Visser M, et al. Taurine concentrations decrease in critically ill patients with shock given enteral nutrition. JPEN J Parenter Enteral Nutr 2015; pii:0148607114567199.
61. Schaffer SW, Jong CJ, Ito T, Azuma J. Effect of taurine on ischemia-reperfusion injury. Amino Acids 2014; 46:21-30.
62. Menzie J, Prentice H, Wu JY. Neuroprotective mechanisms of taurine against ischemic stroke. Brain Sci 2013; 3:877-907.
63. Gharibani P, Modi J, Menzie J, et al. Comparison between single and combined posttreatment with S-Methyl-N, N-diethylthiolcarbamate sulfoxide and taurine following transient focal cerebral ischemia in rat brain. Neuroscience 2015; 300:460-473.
64. Rikimaru M, Ohsawa Y, Wolf AM, et al. Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern Med 2012; 51:3351-3357.
65. Ridley E, Gantner D, Pellegrino V. Nutrition therapy in critically ill patients: a review of current evidence for clinicians. Clin Nutr 2015; 34:565-571.
66. Soeters PB, Bozetti F, Cynober L, et al. Meta-analysis is not enough: the critical role of pathophysiology in determining optimal care in clinical nutrition. Clin Nutr 2016. (In press).