The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patients-A randomized-controlled clinical study

Clinical Nutrition

Volumn 34, Issue 3, 2015, Pages 377-382

  Grintescu, Ioana Marina ^a   Luca Vasiliu, Irina ^a   Cucereanu Badica, Ioana ^a   Mirea, Liliana ^a   Pavelescu, Daniela ^a   Balanescu, Andreea ^a   Grintescu, Ioana Cristina ^a  

^a Clinic Emergency Hospital Bucharest   (Romania)

Author keywords

Critically ill patient; Glutamine dipeptides; Hyperglycemia; Insulin; Parenteral nutrition; Polytrauma

Indexed keywords

ALANYLGLUTAMINE; BRANCHED CHAIN AMINO ACID; GLUCOSE; INSULIN; KABIVEN; PLACEBO; AMINO ACID; CARBOHYDRATE DIET; DIPEPTIDE; FAT INTAKE; GLUCOSE BLOOD LEVEL; GLUTAMINE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; DRUG ADMINISTRATION ROUTE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; ENTERIC FEEDING; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INCIDENCE; INJURY SCALE; INSULIN TREATMENT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; NUTRITIONAL STATUS; NUTRITIONAL SUPPORT; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; ADMINISTRATION AND DOSAGE; ADOLESCENT; BLOOD; CARBOHYDRATE DIET; DIET SUPPLEMENTATION; FAT INTAKE; FOLLOW UP; HOMEOSTASIS; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AMINO ACIDS; BLOOD GLUCOSE; CRITICAL ILLNESS; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY SUPPLEMENTS; DIPEPTIDES; FEMALE; FOLLOW-UP STUDIES; GLUTAMINE; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; MULTIPLE TRAUMA; PARENTERAL NUTRITION; YOUNG ADULT;

EID: 84928208071     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2014.05.006     Document Type: Article

References (18)

1. Wischmeyer P.E., Kahana M.D., Wolfson R., et al. Glutamine induces heat shock protein and protects against endotoxin shock in the rat. JAppl Phys 2001, 90:2403-2410.
2. Brooks D.C., Bessey P.Q., Black P.R., et al. Insulin stimulates branched chain amino acid uptake and diminishes nitrogen flux from skeletal muscle of injured patients. JSurg Res 1986, 40:395-405.
3. Van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in critically ill patients. NEngl J Med 2001, 345:1359-1365.
4. Garmin L., Essen P., Forsberg A.M., et al. Adescriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water and electrolytes. Crit Care Med 1996, 24:575-583.
5. Hammarqvist F., Wernerman J., Ali R., et al. Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis and improves nitrogen balance. Ann Surg 1989, 209:455-461.
6. Oudemans-van Straaten H.M., Bosman H.M., Treskes M., et al. Plasma glutamine depletion and patient outcomes in acute ICU admissions. Intensive Care Med 2001, 27:84-90.
7. van den Berghe G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. NEngl J Med 2006, 354:449-461.
8. Singer P., Berger M.M., Van den Berghe G., et al. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 2009, 28:387-400.
9. Berg A., Bellander B.M., Wanecek M., et al. Intravenous glutamine supplementation to head trauma patients leaves cerebral glutamate concentration unaffected. Intensive Care Med 2006, 32:1741-1746.
10. Déchelotte P., Hasselmann M., Cynober L., et al. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006, 34:598-604.
11. Finfer S., Chittock D.R., Su S.Y., NICE-SUGAR Study Investigators, et al. Intensive versus conventional glucose control in critically ill patients. NEngl J Med 2009, 360:1283-1297.
12. Bagry H.S., Raghvendran S., Carli F. Metabolic syndrome and insulin resistance: perioperative considerations. Anesthesiology 2008, 108:506-523.
13. Gale S.C., Sicoutris C., Reilly P.M., et al. Poor glycemic control in associated with increased mortality in critically ill trauma patients. Am Surg 2007, 73:454-460.
14. Sato H., Carvalho G., Sato T., et al. The association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery. JClin Endocrinol Metab 2010, 95:4338-4344.
15. Oddo M., Schmidt M., Carrera E., et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med 2008, 36:33233-33238.
16. Bouteloup-Demange C., Claeyssens S., Maillot C., et al. Effects of enteral glutamine on gut mucosal protein synthesis in healthy humans receiving glucocorticoids. Am J Physiol Gastrointest Liver Physiol 2000, 278:G677-G681.
17. Heyland D., Muscedere J., Wischmeyer P.E., Cook D., Jones G., Albert M., et al. Arandomized trial of glutamine and antioxidants in critically ill patients. NEngl J Med 2013, 368:1489-1497.
18. Casaer M.P., Hermans G., Wilmer A., Van den Berghe G. Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patients (EPaNIC trial): a study protocol and statistical analysis plan for a randomized controlled trial. Trials 2011; January 24, 12:21. 10.1186/1745-6215-12-21.