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Glutamine modulates sepsis-induced changes to intestinal intraepithelial gdT lymphocyte expression in mice
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Lee WY, Hu YM, Ko TL, et al. Glutamine modulates sepsis-induced changes to intestinal intraepithelial gdT lymphocyte expression in mice. Shock 2012; 38: 288-293.
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Lee, W.Y.1
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Lehmann C, Pavlovic D, Zhou J, et al. Intravenous free and dipeptide-bound glutamine maintains intestinal microcirculation in experimental endotoxemia. Nutrition 2012; 28: 588-593.
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Lehmann, C.1
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Glutamine administration ameliorates sepsisinduced kidney injury by down regulating the high-mobility group box protein- 1-mediated pathway in mice
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Hu YM, Pai MH, Yeh CL, et al. Glutamine administration ameliorates sepsisinduced kidney injury by down regulating the high-mobility group box protein- 1-mediated pathway in mice. Am J Physiol Renal Physiol 2012; 302:F150- F158.
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Hu, Y.M.1
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Alanyl-glutamine resolves lipopolysaccharide- induced lung injury in mice by modulating the polarization of regulatory T cells and T helper 17 cells
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Hou YC, Pai MH, Liu JJ, Yeh SL. Alanyl-glutamine resolves lipopolysaccharide- induced lung injury in mice by modulating the polarization of regulatory T cells and T helper 17 cells. J Nutr Biochem 2013; 24: 1555-1563.
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Hou, Y.C.1
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Liu, J.J.3
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Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: A primary intestinal defect?
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Boutry C, Matsumoto H, Bos C, et al. Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect? Amino Acids 2012; 43: 1485-1498.
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Boutry, C.1
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Kao CC, Hsu JW, Bandi V, Jahoor F. Alterations in glutamine metabolism and its conversion to citrulline in sepsis. Am J Physiol Endocrinol Metab 2013; 304:E1359-E1364. Data presented in this study may be important for a better understanding of the mechanisms of increased nitrogen loss in sepsis.
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Kao, C.C.1
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Cynober L. Amino acid metabolism. In: Lennarz WJ, Lane MD, editors. Encyclopedia of biological chemistry. New York: Elsevier; 2013. pp. 91-96.
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Cynober, L.1
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Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
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Andrews PJD, Avenell A, Noble DB, et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ 2011; 342:d1542.
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Andrews, P.J.D.1
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A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation
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Bollhalder L, Pfeil AM, Tomonaga Y, Schwenkglenks M. A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation. Clin Nutr 2013; 32: 213-223. This meta-analysis seeks to explain why GLN effects on ICU patients are less demonstrative than previously thought in relation to the inclusion of recent multicenter trials.
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Bollhalder, L.1
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Tomonaga, Y.3
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Grau T, Bonet A, Minambres E, et al. The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients. Crit Care Med 2011; 39: 1263-1268.
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Grau, T.1
Bonet, A.2
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Wernerman J, Kirketeig T, Andersson B, et al. Scandinavian glutamine trial: a pragmatic multicentre randomised clinical trial of intensive care unit patients. Acta Anaesthesiol Scand 2011; 55: 812-818.
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Çekmen N, Aydin A, Erdemli Ö. The impact of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on clinical outcome in critically patients. e-SPEN 2011; 6:e64-e67.
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Çekmen, N.1
Aydin, A.2
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A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn
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Lin JJ, Chung XJ, Yang CY, Lau HL. A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn. Burns 2013; 39: 565-570.
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Lin, J.J.1
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Cavalcante AAM, Campelo MWS, De Vasconcelos MPP, et al. Enteral nutrition supplemented with L-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection. Nutrition 2012; 28: 397-402.
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Cavalcante, A.A.M.1
Campelo, M.W.S.2
De Vasconcelos, M.P.P.3
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A randomized trial of glutamine and antioxidants in critically ill patients
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Heyland D, Muscedere J, Wischmeyer PE, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013; 368: 1489-1497. The largest trial on GLN supplementation in ICU patients. However, multiple organ failure is probably not an appropriate indication for GLN supplementation. Also, included patients seem very heterogeneous.
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N Engl J Med
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Heyland, D.1
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Heyland DK, Dhaliwal R. Role of glutamine supplementation in critical illness given the results of the REDOXS study. JPEN J Parenter Enteral Nutr 2013; 37: 442-443.
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Van den Berghe G. Low glutamine levels during critical illness: adaptive or maladaptive? N Engl J Med 2013; 368: 1549-1550. [Letter]
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Rousseau AF, Losser MR, Ichai C, et al. ESPEN endorsed recommendations: nutritional therapy in major burns. Clin Nutr 2013; 32: 497-502.
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Vanek VW, Matarese LE, Robinson M, et al. ASPEN position paper: parenteral nutrition glutamine supplementation. Nutr Clin Pract 2011; 26: 479-494.
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Vanek, V.W.1
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Rodas PC, Rooyackers O, Hebert C, et al. Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci 2012; 122: 591-597. This study extends the previous data showing that low plasmaGLN is a predictor of mortality in ICU patients. It further shows that high GLN levels are also associated with poor prognosis, probably in relation to liver failure.
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Rodas, P.C.1
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Gottshalk A, Wempe C, Goeters C. Glutamine in the ICU: who needs supply? Clin Nutr 2013; 32: 668-669. This study shows that high GLN levels are associated with morbi-mortality in ICU patients. GLN should not be supplied in such patients.
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Clin Nutr
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Gottshalk, A.1
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