Leucine and citrulline: Two major regulators of protein turnover

World Review of Nutrition and Dietetics

Volumn 105, Issue , 2013, Pages 97-105

  Cynober, Luc ^a,b,c   De Bandt, Jean Pascal ^a,b   Moinard, Christophe ^b  

^a HÔTEL DIEU   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Institut Cochin   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHED CHAIN AMINO ACID; CITRULLINE; LEUCINE; MTOR PROTEIN, HUMAN; MUSCLE PROTEIN; TARGET OF RAPAMYCIN KINASE;

BIOSYNTHESIS; BLOOD; GENETICS; HUMAN; INTENSIVE CARE UNIT; METABOLISM; NUTRITIONAL SUPPORT; SIGNAL TRANSDUCTION;

AMINO ACIDS, BRANCHED-CHAIN; CITRULLINE; HUMANS; INTENSIVE CARE UNITS; LEUCINE; MUSCLE PROTEINS; NUTRITIONAL SUPPORT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84870492984     PISSN: 00842230     EISSN: 16623975     Source Type: Book Series    
DOI: 10.1159/000341278     Document Type: Article

References (32)

1. Suryawan A, Hawes J W, Harris RA, Shimomura Y, Jenkins AE, Hutson SM: A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr 1998; 68:72-81. (Pubitemid 28307657)
2. Choudry HA, Pan M, Karinch AM, Souba WW: Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr 2006; 136(Suppl):314S-318S. (Pubitemid 43156531)
3. Tom A, Nair KS: Assessment of branched-chain amino acid status and potential for biomarkers. J Nutr 2006; 136(Suppl):324S-330S. (Pubitemid 43156533)
4. Fernstrom JD: Branched-chain amino acids and brain function. J Nutr 2005; 135(Suppl):1539S-1546S. (Pubitemid 40791667)
5. Dickinson JM, Rasmussen BB: Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism. Curr Opin Clin Nutr Metab Care 2011; 14:83-88.
6. Malaisse WJ: Branched-chain amino and keto acid metabolism in pancreatic islets. Adv Enzyme Regul 1986; 25:203-217.
7. De Bandt J P, Cynober L: Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr 2006; 136(Suppl):308S-313S. (Pubitemid 43156530)
8. Vary TC: Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr 2007; 137:2074-2079. (Pubitemid 47367268)
9. Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC: Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab 2010; 298: E1283-E1294.
10. Biolo G, De Cicco M, Dal Mas V, Lorenzon S, Antonione R, Ciocchi B, et al: Response of muscle protein and glutamine kinetics to branched-chain-enriched amino acids in intensive care patients after radical cancer surgery. Nutrition 2006; 22:475-482.
11. Sun LC, Shih YL, Lu CY, Hsieh JS, Chuang JF, Chen FM, Ma CJ, Wang JY: Randomized, controlled study of branched chain amino acid-enriched total parenteral nutrition in malnourished patients with gastrointestinal cancer undergoing surgery. Am Surg 2008; 74:237-242.
12. Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H, Tejima K, et al: Treatment with leucine stimulates the production of hepatocyte growth factor in vivo. Biochem Biophys Res Commun 2004; 322:772-777. (Pubitemid 39164420)
13. Fan ST, Lo CM, Lai EC, Chu KM, Liu CL, Wong J: Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. N Engl J Med 1994; 331:1547-1552. (Pubitemid 24366901)
14. Okabayashi T, Nishimori I, Sugimoto T, Maeda H, Dabanaka K, Onishi S, et al: Effects of branched-chain amino acids-enriched nutrient support for patients undergoing liver resection for hepatocellular carcinoma. J Gastroenterol Hepatol 2008; 23: 1869-1873.
15. Okabayashi T, Nishimori I, Yamashita K, Sugimoto T, Namikawa T, Maeda H, Yatabe T, Hanazaki K: Preoperative oral supplementation with carbohydrate and branched-chain amino acid-enriched nutrient improves insulin resistance in patients undergoing a hepatectomy: a randomized clinical trial using an artificial pancreas. Amino Acids 2010; 38:901-907.
16. Okabayashi T, Iyoki M, Sugimoto T, Kobayashi M, Hanazaki K: Oral supplementation with carbohydrate-and branched-chain amino acid-enriched nutrients improves postoperative quality of life in patients undergoing hepatic resection. Amino Acids 2011; 40:1213-1220.
17. Yoshida R, Yagi T, Sadamori H, Matsuda H, Shinoura S, Umeda Y, Sato D, Utsumi M, Nagasaka T, Okazaki N, Date A, Noguchi A, Tanaka A, Hasegawa Y, Sakamoto Y, Fujiwara T: Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation. J Hepatobiliary Pancreat Sci 2012; 19: 438-448.
18. Shirabe K, Yoshimatsu M, Motomura T, Takeishi K, Toshima T, Muto J, Matono R, Taketomi A, Uchiyama H, Maehara Y: Beneficial effects of supplementation with branched-chain amino acids on postoperative bacteremia in living donor liver transplant recipients. Liver Transpl 2011; 17:1073-1080.
19. Iresjö BM, Körner U, Larsson B, Henriksson BA, Lundholm K: Appearance of individual amino acid concentrations in arterial blood during steady-state infusions of different amino acid formulations to ICU patients in support of whole-body protein metabolism. JPEN J Parenter Enteral Nutr 2006; 30: 277-285.
20. Bérard M P, Pelletier A, Ollivier JM, Gentil B, Cynober L: Qualitative manipulation of amino acid supply during parenteral nutrition in surgical patients. JPEN J Parenter Enteral Nutr 2002; 26: 136-143. (Pubitemid 34163558)
21. Adibi SA: Metabolism of branched-chain amino acids in altered nutrition. Metabolism 1976; 25: 1287-1302.
22. Fürst P, Elwyn DH, Askanazi J, Kinney J: Effects of nutrition and catabolic stress on intra-cellular branched-chain amino acids; in Wesdorp RIC, Soeters PB (eds): Clinical Nutrition. Edinburgh, Churchill Livingstone, 1981, pp 10-17.
23. Luiking YC, Poeze M, Ramsay G, Deutz NEP: Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89:142-152.
24. Crenn P, Hanachi M, Neveux N, Cynober L: La citrullinémie: un biomarqueur de la fonctionnalité intestinale. Ann Biol Clin 2011; 69:513-521.
25. van Waardenburg DA, de Betue CT, Luiking YC, Engel M, Deutz NEP: Plasma arginine and citrulline concentrations in critically ill children: strong relation with inflammation. Am J Clin Nutr 2007; 86: 1438-1444. (Pubitemid 350126249)
26. Piton G, Manzon C, Monnet E, Cypriani B, Barbot O, Navellou JC, et al: Plasma citrulline kinetics and prognostic value in critically ill patients. Intensive Care Med 2010; 36:702-706.
27. Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G: Acute intestinal failure in critically ill patients: is plasma citrulline the right marker? Intensive Care Med 2011; 37:911-917.
28. Haines RJ, Pendleton LC, Eichler DC: Arginin-osuccinate synthase: at the center of arginine metabolism. Int J Biochem Mol Biol 2011; 2:8-23.
29. Faure C, Raynaud-Simon A, Ferry A, Daugé V, Cynober L, Aussel C, Moinard C: Effects of citrulline and leucine on muscle function in malnourished aged rats. Amino Acids 2012; 42:1425-1433.
30. Le Plénier S, Walrand S, Noirt R, Cynober L, Moinard C: Effects of leucine and citrulline versus non-essential amino acids on muscle protein synthesis in fasted rat: a common activation pathway? Amino Acids 2012, E-pub ahead of print.
31. Batista MA, Nicoli JR, Martins Fdos S, Machado JA, Arantes RM, Quirino IE, Correia MI, Cardoso VN: Pretreatment with citrulline improves gut barrier after intestinal obstruction in mice. JPEN J Parenter Enteral Nutr 2012; 36:69-76.
32. Grisafi D, Tassone E, Dedja A, Oselladore B, Masola V, Guzzardo V, Porzionato A, Salmaso R, Albertin G, Artusi C, Zaninotto M, Onisto M, Milan A, Macchi V, De Caro R, Fassina A, Bordigato MA, hiandetti L, Filippone M, Zaramella P: L: citrulline prevents alveolar and vascular derangement in a rat model of moderate hyperoxia-induced lung injury. Lung 2012; 190:419-430.