The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury

Annals of Surgery

Volumn 259, Issue 1, 2014, Pages 171-178

  Zhu, Xinmei ^a   Pribis, John P ^a   Rodriguez, Paulo C ^b   Morris Jr , Sidney M ^c   Vodovotz, Yoram ^a,d   Billiar, Timothy R ^a   Ochoa, Juan B ^a,c,d  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

Author keywords

Arginase; Arginine; Immune dysfunction; MDSC; Myeloid derived suppressor cells; Physical injury; Surgery; Trauma

Indexed keywords

ARGINASE 1; ARGININE; CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CATABOLISM; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; IN VIVO STUDY; INFECTION SENSITIVITY; INJURY; LISTERIA MONOCYTOGENES; LYMPHOCYTE PROLIFERATION; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PHYSICAL INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPRESSOR CELL; T CELL DEPLETION;

ANIMALS; ARGINASE; ARGININE; DISEASE MODELS, ANIMAL; LISTERIOSIS; MICE; MICE, INBRED C57BL; MYELOID CELLS; T-LYMPHOCYTES; WOUNDS AND INJURIES;

EID: 84891632581     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e31828611f8     Document Type: Article

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