Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway

Journal of Molecular Neuroscience

Volumn 58, Issue 1, 2016, Pages 28-38

  Li, Yu ^a   Dai, Yu bing ^b   Sun, Jie yun ^a   Xiang, Yue ^a   Yang, Jun ^a   Dai, Song yang ^a   Zhang, Xiong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b GUIZHOU PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Alzheimer s disease; Beta amyloid; Caspases; Neuroglobin; PI3K Akt pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CASPASE; CASPASE 3; CASPASE 9; NEUROGLOBIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; GLOBIN; NERVE PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REFERENCE MEMORY; SENILE PLAQUE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; AMYLOID PLAQUE; ANIMAL; GENETICS; HUMAN; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; SECOND MESSENGER; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; FEMALE; GLOBINS; HUMANS; MALE; MAZE LEARNING; MICE; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PLAQUE, AMYLOID; PROTO-ONCOGENE PROTEINS C-AKT; SECOND MESSENGER SYSTEMS;

EID: 84957434009     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0645-z     Document Type: Article

References (36)

1. Antao ST, Duang TT, Aran R, Witting PK (2010) Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial K (ATP) channel. Antioxid Redox Signal 13(6):769–781
2. Brittain T, Skommer J, Raychaudhuri S, Birch N (2010) An antiapoptotic neuroprotective role for neuroglobin. Int J Mol Sci 11(6):2306–2321
3. Brunori M, Vallone B (2006) A globin for the brain. FASEB J 20:2192–2197
4. Burmester T, Weich B, Reinhardt S, Hankeln T (2000) A vertebrate globin expressed in the brain. Nature 407(6803):520–523
5. De Calignon A, Fox LM, Pitstick R et al (2010) Caspase activation precedes and leads to tangles. Nature 464(7292):1201–1204
6. Fordel E, Thus L, Martinet W et al (2006) Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. Neurosci Lett 410(2):146–151
7. Francois G, Daigen X, George S et al (1999) Involvement of caspases inproteolytic cleavage of Alzheimer’ amyloid-beta precursor protein and amyloidogenin Abeta peptide formation. Cell 97(3):395–406
8. Galimberti D, Scarpini E (2011) Alzheimer’s disease: from pathogenesis to disease-modifying approaches. CNS Neurol Disord Drug Targets 10(2):163–174
9. Golde TE, Dickson D, Hutton M (2006) Filling the gaps in the Abeta cascade hypothesis of Alzheimer’s disease. Curr Alzheimers Res 3(5):421–430
10. Hajra KM, Liu JR (2004) Apoptosome dysfunction in human cancer. Apoptosis 9:691–704
11. Hedskog L, Petersen CA, Al S et al (2011) Gamma-secretase complexes containing caspase-cleaved presenlin-1 increase intracellular Aβ42/Aβ40 ratio. Cell Mol Med 15(10):2150–2163
12. Hoi CP, Ho YP, Baum L, Chow AH (2010) Neuroprotective effect of honokiol and magnolol compunds from Magnolia officinalis on beta-amyloid-induced toxicity in PC12 cells. Phytother Res 24(10):1538–1542
13. Jin K, Mao Y, Mao X, Xie L, Greenberg DA (2010) Neuroglobin expression in ischemic stroke. Stroke 41(3):557–559
14. Khan AA, Mao XO, Banwait S, Jin K, Greenberg DA (2007) Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci U S A 104(48):10114–10119
15. Li RC, Pouranfar F, Lee SK, Morris MW, Wang Y, Gozal D (2008) Neuroglobin protects PC12 cells against beta-amyloid-induced cell injury. Neurobiol Aging 29(12):1815–1822
16. Li C, Zhao R, Gao K et al (2011) Astrocytes: implication for neuroinflammatory pathogenesis of Alzheimer’s disease. Curr Alzheimers Res 80(1):67–80
17. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21(21):8370–8377
18. Ord EN, Shirley R, McClure JD et al (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. J Cereb Blood Flow Metab 33(8):1215–1224
19. Raina AK, Hochman A, Zhu X et al (2001) Abortive apoptosis in Alzheimer’s disease. Acta Neuropathol 101(4):305–310
20. Redlak MJ, Miller TA (2011) Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. Dig Dis Sci 56(2):323–329
21. Richard CL, Pouranfar F, Lee SK, Matthew WM, Yang W, Gozal D (2008) Neuroglobin protects PC12 cell against β-amyloid induced cell injury. Neurobiol Aging 29(12):1815–1822
22. Schmidt M, Giessl A, Laufs T, Hankeln T, Wolfrum U, Burmester T (2003) How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J Biol Chem 278:1932–1935
23. Singh S, Zhuo M, Gorgun FM, Englander EW (2013) Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons. Nitric Oxide 32:21–28
24. Song Z, Insel PS, Buckley S et al (2015) Brain amyloid-beta burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly. J Neurosci 35(7):3240–3247
25. Sun Y, Jin K, Mao XO et al (2005) Effect of aging on neuroglobin expression in rodent brain. Neurobiol Aging 26(2):275–278
26. Sun F, Mao X, Xie L, Greenberga DA, Jin K (2013) Neuroglobin protein is upregulated in Alzheimer’s disease. J Alzheimers Dis 36(4):659–663
27. Szymanski M, Wang R, Fallin MD, Bassett SS, Avramopoulos D (2010) Neuroglobin and Alzheimer’s dementia: genetic association and gene expression changes. Neurobiol Aging 31(11):1835–1842
28. Wang Y, Xu S, Cao Y et al (2014) Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpresssion of DR4 together with altering DNMTs in Alzhemer’s disease. Int J Clin Exp Med 7(8):1945–57
29. Wei X, Yu Z, Cho KS et al (2011) Neuroglobin is an endogenousneuroprotectant for retinal ganglion cells against glaucomatousdamage. Am J Pathol 179:2988–1997
30. Yu W, Mechawar N, Krantic S, Quirion R (2010) Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease. Am J Pathol 176(5):2209–2218
31. Yuan JY, Yanker BA (2000) Apoptosis in the nervous system. Nature 407(6805):802–809
32. Zara S, Di Stefano A, Nasuti C et al (2011) NOS-mediated morphological and molecular modifications in rats infused with Aβ(1–40), as a model of Alzheimer’s disease, in response to a new lipophilic molecular combination codrug-1. Exp Gerontol 46(10):273–281
33. Zara S, Porzionato A, De Colli M et al (2013) Human carotid body neuroglobin, vascular endothelial growth factor and inducible nitric oxide synthase expression in heroin addiction. Histol Histopathol 28(7):903–911
34. Zhang X, Yin WK, Shi XD, Li Y (2011) Curcumin activates wnt/β-catenin signaling pathway through inhibiting the activity of gsk-3β in vitro. Eur J Pharm Sci 42(5):540–546
35. Zhao R, Zhang Z, Song Y, Wang D, Qi J, Wen S (2011) Implication of phosphatidylinositol-3kinas/Akt/glycogen synthase kinase-3beta pathway in ginsenoside Rb1’s attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. J Ethnopharmacol 133(3):1109–1116
36. Zhu J, Tang W (2010) Cerebroprotection with recombinant neuroglobin plasmid in a rat model of focal cerebral ischemia. Neural Regen Res 5(1):52–57