Human carotid body neuroglobin, vascular endothelial growth factor and inducible nitric oxide synthase expression in heroin addiction

Histology and Histopathology

Volumn 28, Issue 7, 2013, Pages 903-911

  Zara, S ^a   Porzionato, A ^b   De Colli, M ^a   Macchi, V ^b   Cataldi, A ^a   De Caro, R ^b   Di Giulio, C ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Carotid body; Chemoreceptor; Heroin addiction; Hypoxia; NGB

Indexed keywords

BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASPASE 3; GLOBIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; NERVE PROTEIN; NEUROGLOBIN; NITROGEN; NOS2 PROTEIN, HUMAN; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ANOXIA; ARTICLE; AUTOPSY; CAROTID ARTERY; CAROTID BODY; CHEMISTRY; HEROIN DEPENDENCE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PATHOLOGY;

ADULT; ANOXIA; AUTOPSY; BCL-2-ASSOCIATED X PROTEIN; CAROTID ARTERIES; CAROTID BODY; CASPASE 3; GLOBINS; HEROIN DEPENDENCE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; NITROGEN; REACTIVE OXYGEN SPECIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84879770790     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Awenius C., Hankeln T. and Burmester T. (2001). Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem. Biophys. Res. Commun. 287, 418-421.
2. Brittain T., Skommer J., Henty K., Birch N. and Raychaudhuri S. (2010a). A role for human neuroglobin in apoptosis. IUBMB Life 62, 878-885.
3. Brittain T., Skommer J., Raychaudhuri S. and Birch N. (2010b). An antiapoptotic neuroprotective role for neuroglobin. Int. J. Mol. Sci. 11, 2306-2321.
4. Brunori M. and Vallone B. (2007). Neuroglobin, seven years after. Cell. Mol. Life Sci. 64, 259-68.
5. Burmester T. and Hankeln T. (2009). What is the function of neuroglobin? J. Exp. Biol. 212, 1423-1428.
6. Burmester T., Weich B., Reinhardt S. and Hankeln T. (2000). A vertebrate globin expressed in the brain. Nature 407, 520-523.
7. Cataldi A. and Di Giulio C. (2009). "Oxygen supply" as modulator of aging processes: hypoxia and hyperoxia models for aging studies. Curr. Aging Sci. 2, 95-102.
8. Del Rio R., Moya E.A. and Iturriaga R. (2011). Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia. Brain Res. 1395, 74-85.
9. Di Giulio C., Cacchio M., Bianchi G., Rapino C. and Di Ilio C. (2003). Selected Contribution: Carotid body as a model for aging studies: is there a link between oxygen and aging? J. Appl. Physiol. 95, 1755-1758.
10. Di Giulio C., Bianchi G., Cacchio M., Artese L., Rapino C., Macrì M.A. and Di Ilio C. (2005). Oxigen and life span: chronic hypoxia as a model for studying HIF-1m, VEGF and NOS during aging. Respir. Physiol. Neurobiol. 147, 31-38.
11. Di Giulio C., Bianchi G., Cacchio M., Artese L., Piccirilli M., Verratti V., Valerio R. and Iturriaga R. (2006). Neuroglobin, a new oxygen binding protein is present in the carotid body and increases after chronic intermittent hypoxia. Adv. Exp. Med. Biol. 580, 15-9.
12. Fago A., Mathews A.J. and Brittain T. (2008). A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cells. IUBMB Life 60, 398-401.
13. Fechir M., Breimhorst M., Kritzmann S., Geber C., Schlereth T., Baier B. and Birklein F. (2012). Naloxone inhibits not only stress-induced analgesia but also sympathetic activation and baroreceptor-reflex sensitivity. Eur. J. Pain 16, 82-92.
14. García-Fernández M., Ortega-Sáenz P., Castellano A. and López-Barneo J. (2007). Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes 56, 2893-900.
15. Herold S., Fago A., Weber R.E., Dewilde S. and Moens L. (2004). Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stress. J. Biol. Chem. 279, 22841-22847.
16. Iturriaga R. and Alcayaga J. (2004). Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals. Brain Res. Brain Res. Rev. 47, 46-53.
17. Kameda Y. (2005). Mash1 is required for glomus cell formation in the mouse carotid body. Dev. Biol. 283, 128-139.
18. Kirby G.C. and McQueen D.S. (1986). Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo. Br. J. Pharmacol. 88, 889-98.
19. Leiser S.F. and Kaeberlein M. (2010). The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol. Chem. 391, 1131-1137.
20. López-Barneo J., Ortega-Sáenz P., Pardal R., Pascual A., Piruat J.I., Durán R. and Gómez-Díaz R. (2009). Oxygen sensing in the carotid body. Ann. NY Acad. Sci. 1177, 119-31.
21. Pallot D.J., Al Neamy K.W. and Blakeman N. (1986). Quantitative studies of rat carotid body type I cells. Acta Anat. (Basel). 126, 187-92.
22. Pardal R., Ortega-Sáenz P., Durán R., López-Barneo J. (2007). Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131, 364-77.
23. Pokorski M. and Lahiri S. (1981). Effects of naloxone on carotid body chemoreception and ventilation in the cat. J. Appl. Physiol. 51, 1533-1538.
24. Pokorski M. and Lahiri S. (1991). Endogenous opiates and ventilatory acclimatization to chronic hypoxia in the cat. Respir. Physiol. 83, 211-21.
25. Porzionato A., Macchi V., Guidolin D., Parenti A., Ferrara S.D. and De Caro R. (2005). Histopathology of carotid body in heroin addiction. Possible chemosensitive impairment. Histopathology 46, 296-306.
26. Porzionato A., Macchi V., Parenti A. and De Caro R. (2009). Chronic carotid glomitis in heroin addiction. Histol. Histopathol. 24, 707-715.
27. Sun Y., Jin K., Mao X.O., Xie L., Peel A., Childs J.T., Logvinova A., Wang X. and Greenberg D.A. (2005). Effect of aging on neuroglobin expression in rodent brain. Neurobiol. Aging 26, 275-8.
28. Sun Y., Jin K., Mao X.O., Zhu Y. and Greenberg D.A. (2011). Neuroglobin is up-regulated by and protects neurons from hypoxicischemic injury. Proc. Natl. Acad. Sci. USA 98, 15306-11.
29. Varas R., Valdés V., Iturriaga-Vásquez P., Cassels B.K., Iturriaga R. and Alcayaga J. (2006). Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: effects of cytisine and its bromo derivatives. Brain Res. 1072, 72-8.
30. Verna A. (1979). Ulstrastructure of the carotid body in the mammals. Int. Rev. Cytol. 60, 271-330.
31. Verratti V., Di Giulio C., Bianchi G., Cacchio M., Petruccelli G., Di Giulio C., Artese L., Lahiri S. and Iturriaga R. (2009). Neuroglobin in aging carotid bodies. Adv. Exp. Med. Biol. 648, 191-195.
32. White J.M. and Irvine R.J. (1999). Mechanisms of fatal opioid overdose. Addiction 94, 961-972.
33. Ye J. S, Tipoe G.L., Fung P.C. and Fung M.L. (2002). Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: an involvement of constitutive and inducible nitric oxide synthases. Pflugers. Arch. 444, 178-185.
34. Yu T., Wang X., Purring-Koch C., Wie Y. and McLendon G.L. (2001). A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J. Biol. Chem. 276, 13034-13038.
35. Zara S., Rapino M., Centurione L., di Giacomo V., Petruccelli G. and Cataldi A. (2010). Inducible nitric oxide synthase-activated mitochondrial apoptotic pathway in hypoxic and aged rat hearts. Gerontology 56, 544-552.
36. Zara S., Cataldi A., Pokorski M., Porzionato A., De Caro R. and Di Giulio C. (2012). Development and aging are oxygen-dependent and are correlated with VEGF-NOS along life-span. Adv. Exp. Med. Biol. 756.
37. Zhang X.L., Yan Z.W., Sheng W.W., Xiao J., Zhang Z.X. and Ye Z.B. (2011). Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase. Mol. Cell. Biochem. 358, 287-295.