메뉴 건너뛰기




Volumn 11, Issue 2, 2016, Pages 182-190

Microbial translocation and microbiome dysbiosis in HIV-associated immune activation

Author keywords

HIV AIDS; inflammation; microbial translocation; microbiome; mucosal

Indexed keywords

BACTERIAL IMMUNITY; BACTERIAL TRANSLOCATION; BACTEROIDES; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DISEASE COURSE; DYSBIOSIS; GASTROINTESTINAL TRACT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; LAMINA PROPRIA; MICROBIAL COMMUNITY; MICROBIAL DYSBIOSIS; MICROBIAL TRANSLOCATION; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; IMMUNOLOGY; MICROBIOLOGY; MICROFLORA; PATHOPHYSIOLOGY;

EID: 84957433925     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000234     Document Type: Review
Times cited : (178)

References (108)
  • 1
    • 84934768447 scopus 로고    scopus 로고
    • HIV and mucosal barrier interactions: Consequences for transmission and pathogenesis
    • Burgener A, McGowan I, Klatt NR. HIV and mucosal barrier interactions: consequences for transmission and pathogenesis. Curr Opin Immunol 2015; 36: 22-30.
    • (2015) Curr Opin Immunol , vol.36 , pp. 22-30
    • Burgener, A.1    McGowan, I.2    Klatt, N.R.3
  • 2
    • 84928078278 scopus 로고    scopus 로고
    • Gut epithelial barrier and systemic inflammation during chronic HIV infection
    • Somsouk M, Estes JD, Deleage C, et al. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS 2015; 29: 43-51.
    • (2015) AIDS , vol.29 , pp. 43-51
    • Somsouk, M.1    Estes, J.D.2    Deleage, C.3
  • 3
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey RS, DeMaria M, Chalifoux LV, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998; 280: 427-431.
    • (1998) Science , vol.280 , pp. 427-431
    • Veazey, R.S.1    DeMaria, M.2    Chalifoux, L.V.3
  • 4
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallil JJ, Douek DC, Hill B, et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005; 434: 1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3
  • 5
    • 54449084622 scopus 로고    scopus 로고
    • Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
    • Macal M, Sankaran S, Chun TW, et al. Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol 2008; 1: 475-488.
    • (2008) Mucosal Immunol , vol.1 , pp. 475-488
    • Macal, M.1    Sankaran, S.2    Chun, T.W.3
  • 6
    • 44649201289 scopus 로고    scopus 로고
    • HIV infection and the gastrointestinal immune system
    • Brenchley JM, Douek DC. HIV infection and the gastrointestinal immune system. Mucosal Immunol 2008; 1: 23-30.
    • (2008) Mucosal Immunol , vol.1 , pp. 23-30
    • Brenchley, J.M.1    Douek, D.C.2
  • 7
    • 35348841509 scopus 로고    scopus 로고
    • Tight junctions/adherens junctions: Basic structure and function
    • Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol 2007; 127: 2525-2532.
    • (2007) J Invest Dermatol , vol.127 , pp. 2525-2532
    • Niessen, C.M.1
  • 8
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009; 9: 799-809.
    • (2009) Nat Rev Immunol , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 9
    • 84953296603 scopus 로고    scopus 로고
    • Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIVsusceptible target cells
    • Arnold KB, Burgener A, Birse K, et al. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIVsusceptible target cells. Mucosal Immunol 2015. doi: 10.1038/mi.2015.51.
    • (2015) Mucosal Immunol
    • Arnold, K.B.1    Burgener, A.2    Birse, K.3
  • 10
    • 84919665923 scopus 로고    scopus 로고
    • Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation
    • Schuetz A, Deleage C, Sereti I, et al. Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog 2014; 10: e1004543.
    • (2014) PLoS Pathog , vol.10 , pp. e1004543
    • Schuetz, A.1    Deleage, C.2    Sereti, I.3
  • 11
    • 84919343324 scopus 로고    scopus 로고
    • Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells
    • McKinnon LR, Nyanga B, Kim CJ, et al. Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells. J Acquir Immune Defic Syndr 2015; 68: 6-12.
    • (2015) J Acquir Immune Defic Syndr , vol.68 , pp. 6-12
    • McKinnon, L.R.1    Nyanga, B.2    Kim, C.J.3
  • 12
    • 41849142985 scopus 로고    scopus 로고
    • Simian immunodeficiency virusinduced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    • Raffatellu M, Santos RL, Verhoeven DE, et al. Simian immunodeficiency virusinduced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med 2008; 14: 421-428.
    • (2008) Nat Med , vol.14 , pp. 421-428
    • Raffatellu, M.1    Santos, R.L.2    Verhoeven, D.E.3
  • 13
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006; 6: 173-182.
    • (2006) Nat Rev Immunol , vol.6 , pp. 173-182
    • Nathan, C.1
  • 14
    • 77958083540 scopus 로고    scopus 로고
    • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    • Estes JD, Harris LD, Klatt NR, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog 2010; 6: e1001052.
    • (2010) PLoS Pathog , vol.6 , pp. e1001052
    • Estes, J.D.1    Harris, L.D.2    Klatt, N.R.3
  • 15
    • 84893792899 scopus 로고    scopus 로고
    • Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration
    • Sereti I, Estes JD, Thompson WL, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog 2014; 10: e1003890.
    • (2014) PLoS Pathog , vol.10 , pp. e1003890
    • Sereti, I.1    Estes, J.D.2    Thompson, W.L.3
  • 16
    • 77954059792 scopus 로고    scopus 로고
    • Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    • Nazli A, Chan O, Dobson-Belaire WN, et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog 2010; 6: e1000852.
    • (2010) PLoS Pathog , vol.6 , pp. e1000852
    • Nazli, A.1    Chan, O.2    Dobson-Belaire, W.N.3
  • 17
    • 37349078686 scopus 로고    scopus 로고
    • Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration
    • Sankaran S, George MD, Reay E, et al. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol 2008; 82: 538-545.
    • (2008) J Virol , vol.82 , pp. 538-545
    • Sankaran, S.1    George, M.D.2    Reay, E.3
  • 18
    • 0028072532 scopus 로고
    • Cytokine gene expression in HIVinfected intestinal mucosa
    • McGowan I, Radford-Smith G, Jewell DP. Cytokine gene expression in HIVinfected intestinal mucosa. AIDS 1994; 8: 1569-1575.
    • (1994) AIDS , vol.8 , pp. 1569-1575
    • McGowan, I.1    Radford-Smith, G.2    Jewell, D.P.3
  • 19
    • 84930974237 scopus 로고    scopus 로고
    • Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption
    • Hirao LA, Grishina I, BourryO, et al. Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption. PLoS Pathog 2014; 10: e1004311.
    • (2014) PLoS Pathog , vol.10 , pp. e1004311
    • Hirao, L.A.1    Grishina, I.2    Bourry, O.3
  • 20
    • 0034967731 scopus 로고    scopus 로고
    • HIV-related diarrhea is multifactorial and fat malabsorption is commonly present, independent of HAART
    • Poles MA, Fuerst M, McGowan I, et al. HIV-related diarrhea is multifactorial and fat malabsorption is commonly present, independent of HAART. Am J Gastroenterol 2001; 96: 1831-1837.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1831-1837
    • Poles, M.A.1    Fuerst, M.2    McGowan, I.3
  • 21
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12: 1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 22
    • 33645924682 scopus 로고    scopus 로고
    • HIV disease: Fallout from a mucosal catastrophe?
    • Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006; 7: 235-239.
    • (2006) Nat Immunol , vol.7 , pp. 235-239
    • Brenchley, J.M.1    Price, D.A.2    Douek, D.C.3
  • 23
  • 24
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • Kau AL, Ahern PP, Griffin NW, et al. Human nutrition, the gut microbiome and the immune system. Nature 2011; 474: 327-336.
    • (2011) Nature , vol.474 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3
  • 25
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature 2012; 489: 220-230.
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3
  • 26
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203.
    • (2008) PLoS Med , vol.5 , pp. e203
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3
  • 27
    • 70349434886 scopus 로고    scopus 로고
    • Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection
    • Rodger AJ, Fox Z, Lundgren JD, et al. Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis 2009; 200: 973-983.
    • (2009) J Infect Dis , vol.200 , pp. 973-983
    • Rodger, A.J.1    Fox, Z.2    Lundgren, J.D.3
  • 28
    • 79952335046 scopus 로고    scopus 로고
    • Plasma levels of soluble CD14 independently predict mortality in HIV infection
    • Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203: 780-790.
    • (2011) J Infect Dis , vol.203 , pp. 780-790
    • Sandler, N.G.1    Wand, H.2    Roque, A.3
  • 29
    • 49649129676 scopus 로고    scopus 로고
    • Microbial translocation is associated with increased monocyte activation and dementia in AIDS Patients
    • Ancuta P, Kamat A, Kunstman KJ, et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS Patients. PLoS One 2008; 3: e2516.
    • (2008) PLoS One , vol.3 , pp. e2516
    • Ancuta, P.1    Kamat, A.2    Kunstman, K.J.3
  • 30
    • 77955690397 scopus 로고    scopus 로고
    • Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy
    • Cassol E, Malfeld S, Mahasha P, et al. Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy. J Infect Dis 2010; 202: 723-733.
    • (2010) J Infect Dis , vol.202 , pp. 723-733
    • Cassol, E.1    Malfeld, S.2    Mahasha, P.3
  • 31
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199: 1177-1185.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 32
    • 84874843050 scopus 로고    scopus 로고
    • Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques
    • Canary LA, Vinton CL, Morcock DR, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol 2013; 190: 2959-2965.
    • (2013) J Immunol , vol.190 , pp. 2959-2965
    • Canary, L.A.1    Vinton, C.L.2    Morcock, D.R.3
  • 33
    • 44849137950 scopus 로고    scopus 로고
    • Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    • Funderburg N, Luciano AA, Jiang W, et al. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One 2008; 3: e1915.
    • (2008) PLoS One , vol.3 , pp. e1915
    • Funderburg, N.1    Luciano, A.A.2    Jiang, W.3
  • 34
    • 67650673055 scopus 로고    scopus 로고
    • Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopenia
    • Lee PI, Ciccone EJ, Read SW, et al. Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopenia. J Infect Dis 2009; 199: 1664-1670.
    • (2009) J Infect Dis , vol.199 , pp. 1664-1670
    • Lee, P.I.1    Ciccone, E.J.2    Read, S.W.3
  • 35
    • 77953739215 scopus 로고    scopus 로고
    • Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
    • Klatt NR, Harris LD, Vinton CL, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol 2010; 3: 387-398.
    • (2010) Mucosal Immunol , vol.3 , pp. 387-398
    • Klatt, N.R.1    Harris, L.D.2    Vinton, C.L.3
  • 36
    • 84902281875 scopus 로고    scopus 로고
    • Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
    • Hunt PW, Sinclair E, Rodriguez B, et al. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis 2014; 210: 1228-1238.
    • (2014) J Infect Dis , vol.210 , pp. 1228-1238
    • Hunt, P.W.1    Sinclair, E.2    Rodriguez, B.3
  • 37
    • 84880540665 scopus 로고    scopus 로고
    • Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
    • Vujkovic-Cvijin I, Dunham RM, Iwai S, et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med 2013; 5: 193ra191.
    • (2013) Sci Transl Med , vol.5 , pp. 193ra191
    • Vujkovic-Cvijin, I.1    Dunham, R.M.2    Iwai, S.3
  • 38
    • 84929633864 scopus 로고    scopus 로고
    • Dysbiotic bacteria translocate in progressive SIV infection
    • Klase Z, Ortiz A, Deleage C, et al. Dysbiotic bacteria translocate in progressive SIV infection. Mucosal Immunol 2015; 8: 1009-1020.
    • (2015) Mucosal Immunol , vol.8 , pp. 1009-1020
    • Klase, Z.1    Ortiz, A.2    Deleage, C.3
  • 39
    • 84888084911 scopus 로고    scopus 로고
    • The interplay between the innate immune system and the microbiota
    • Thaiss CA, Levy M, Suez J, Elinav E. The interplay between the innate immune system and the microbiota. Curr Opin Immunol 2014; 26: 41-48.
    • (2014) Curr Opin Immunol , vol.26 , pp. 41-48
    • Thaiss, C.A.1    Levy, M.2    Suez, J.3    Elinav, E.4
  • 40
    • 84903616167 scopus 로고    scopus 로고
    • Exploiting gut bacteriophages for human health
    • Dalmasso M, Hill C, Ross RP. Exploiting gut bacteriophages for human health. Trends Microbiol 2014; 22: 399-405.
    • (2014) Trends Microbiol , vol.22 , pp. 399-405
    • Dalmasso, M.1    Hill, C.2    Ross, R.P.3
  • 41
    • 84916898718 scopus 로고    scopus 로고
    • The bacteriome-mycobiome interaction and antifungal host defense
    • Oever JT, Netea MG. The bacteriome-mycobiome interaction and antifungal host defense. Eur J Immunol 2014; 44: 3182-3191.
    • (2014) Eur J Immunol , vol.44 , pp. 3182-3191
    • Oever, J.T.1    Netea, M.G.2
  • 43
    • 84900493012 scopus 로고    scopus 로고
    • An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
    • Dillon SM, Lee EJ, Kotter CV, et al. An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. Mucosal Immunol 2014; 7: 983-994.
    • (2014) Mucosal Immunol , vol.7 , pp. 983-994
    • Dillon, S.M.1    Lee, E.J.2    Kotter, C.V.3
  • 44
    • 84883855720 scopus 로고    scopus 로고
    • Alterations in the gut microbiota associated with HIV-1 infection
    • Lozupone CA, Li M, Campbell TB, et al. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe 2013; 14: 329-339.
    • (2013) Cell Host Microbe , vol.14 , pp. 329-339
    • Lozupone, C.A.1    Li, M.2    Campbell, T.B.3
  • 45
    • 84895733084 scopus 로고    scopus 로고
    • A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    • Mutlu EA, Keshavarzian A, Losurdo J, et al. A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects. PLoS Pathog 2014; 10: e1003829.
    • (2014) PLoS Pathog , vol.10 , pp. e1003829
    • Mutlu, E.A.1    Keshavarzian, A.2    Losurdo, J.3
  • 46
    • 84902595278 scopus 로고    scopus 로고
    • HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota
    • McHardy IH, Li X, Tong M, et al. HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota. Microbiome 2013; 1: 1-12.
    • (2013) Microbiome , vol.1 , pp. 1-12
    • McHardy, I.H.1    Li, X.2    Tong, M.3
  • 47
    • 85027927719 scopus 로고    scopus 로고
    • Enterotypes of the human gut microbiome
    • Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature 2011; 473: 174-180.
    • (2011) Nature , vol.473 , pp. 174-180
    • Arumugam, M.1    Raes, J.2    Pelletier, E.3
  • 48
    • 84879760435 scopus 로고    scopus 로고
    • Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
    • Kang DW, Park JG, Ilhan ZE, et al. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One 2013; 8: e68322.
    • (2013) PLoS One , vol.8 , pp. e68322
    • Kang, D.W.1    Park, J.G.2    Ilhan, Z.E.3
  • 49
    • 84887323708 scopus 로고    scopus 로고
    • Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    • Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2013; 2: e01202.
    • (2013) Elife , vol.2 , pp. e01202
    • Scher, J.U.1    Sczesnak, A.2    Longman, R.S.3
  • 50
    • 80052473669 scopus 로고    scopus 로고
    • The intestinal microbiota and chronic disorders of the gut
    • DuPont AW, DuPont HL. The intestinal microbiota and chronic disorders of the gut. Nat Rev Gastroenterol Hepatol 2011; 8: 523-531.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 523-531
    • DuPont, A.W.1    DuPont, H.L.2
  • 51
    • 84917707017 scopus 로고    scopus 로고
    • Dysbiotic events in gut microbiota: Impact on human health
    • Schippa S, Conte MP. Dysbiotic events in gut microbiota: impact on human health. Nutrients 2014; 6: 5786-5805.
    • (2014) Nutrients , vol.6 , pp. 5786-5805
    • Schippa, S.1    Conte, M.P.2
  • 52
    • 84934788655 scopus 로고    scopus 로고
    • Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection
    • Dillon SM, Lee EJ, Kotter CV, et al. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection. Mucosal Immunol 2015; 7: 983-994.
    • (2015) Mucosal Immunol , vol.7 , pp. 983-994
    • Dillon, S.M.1    Lee, E.J.2    Kotter, C.V.3
  • 53
    • 38949134533 scopus 로고    scopus 로고
    • Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
    • Gori A, Tincati C, Rizzardini G, et al. Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis. J Clin Microbiol 2008; 46: 757-758.
    • (2008) J Clin Microbiol , vol.46 , pp. 757-758
    • Gori, A.1    Tincati, C.2    Rizzardini, G.3
  • 54
    • 3042774208 scopus 로고    scopus 로고
    • Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation
    • Eschbach M, Schreiber K, Trunk K, et al. Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol 2004; 186: 4596-4604.
    • (2004) J Bacteriol , vol.186 , pp. 4596-4604
    • Eschbach, M.1    Schreiber, K.2    Trunk, K.3
  • 55
    • 79959850621 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa opportunistic pathogen and human infections
    • de Bentzmann S, Plesiat P. The Pseudomonas aeruginosa opportunistic pathogen and human infections. Environ Microbiol 2011; 13: 1655-1665.
    • (2011) Environ Microbiol , vol.13 , pp. 1655-1665
    • De Bentzmann, S.1    Plesiat, P.2
  • 57
    • 84882312793 scopus 로고    scopus 로고
    • Metabolic niche of a prominent sulfatereducing human gut bacterium
    • Rey FE, Gonzalez MD, Cheng J, et al. Metabolic niche of a prominent sulfatereducing human gut bacterium. Proc Natl Acad Sci 2013; 110: 13582-13587.
    • (2013) Proc Natl Acad Sci , vol.110 , pp. 13582-13587
    • Rey, F.E.1    Gonzalez, M.D.2    Cheng, J.3
  • 58
    • 84868097094 scopus 로고    scopus 로고
    • The success of acinetobacter species; Genetic, metabolic and virulence attributes
    • Peleg AY, de Breij A, Adams MD, et al. The success of acinetobacter species; genetic, metabolic and virulence attributes. PLoS One 2012; 7: e46984.
    • (2012) PLoS One , vol.7 , pp. e46984
    • Peleg, A.Y.1    De Breij, A.2    Adams, M.D.3
  • 59
    • 77956367086 scopus 로고    scopus 로고
    • Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response
    • March C, Regueiro V, Llobet E, et al. Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response. PLoS One 2010; 5: e10033.
    • (2010) PLoS One , vol.5 , pp. e10033
    • March, C.1    Regueiro, V.2    Llobet, E.3
  • 60
    • 0022592731 scopus 로고
    • Pathophysiology of Campylobacter enteritis
    • Walker RI, Caldwell MB, Lee EC, et al. Pathophysiology of Campylobacter enteritis. Microbiol Rev 1986; 50: 81-94.
    • (1986) Microbiol Rev , vol.50 , pp. 81-94
    • Walker, R.I.1    Caldwell, M.B.2    Lee, E.C.3
  • 61
    • 79958796471 scopus 로고    scopus 로고
    • Novel murine infection models provide deep insights into the 'menage a trois' of Campylobacter jejuni, microbiota and host innate immunity
    • Bereswill S, Fischer A, Plickert R, et al. Novel murine infection models provide deep insights into the 'menage a trois' of Campylobacter jejuni, microbiota and host innate immunity. PLoS One 2011; 6: e20953.
    • (2011) PLoS One , vol.6 , pp. e20953
    • Bereswill, S.1    Fischer, A.2    Plickert, R.3
  • 62
    • 38349049462 scopus 로고    scopus 로고
    • Polysaccharide utilization by gut bacteria: Potential for new insights from genomic analysis
    • Flint HJ, Bayer EA, Rincon MT, et al. Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat Rev Microbiol 2008; 6: 121-131.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 121-131
    • Flint, H.J.1    Bayer, E.A.2    Rincon, M.T.3
  • 63
    • 78149283854 scopus 로고    scopus 로고
    • Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    • Png CW, Linden SK, Gilshenan KS, et al. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol 2010; 105: 2420-2428.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2420-2428
    • Png, C.W.1    Linden, S.K.2    Gilshenan, K.S.3
  • 64
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science 2012; 336: 1262-1267.
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.3
  • 65
    • 84863621018 scopus 로고    scopus 로고
    • HIV-1 infection of human intestinal lamina propria CD4+ T cells in vitro is enhanced by exposure to commensal Escherichia coli
    • Dillon SM, Manuzak JA, Leone AK, et al. HIV-1 infection of human intestinal lamina propria CD4+ T cells in vitro is enhanced by exposure to commensal Escherichia coli. J Immunol 2012; 189: 885-896.
    • (2012) J Immunol , vol.189 , pp. 885-896
    • Dillon, S.M.1    Manuzak, J.A.2    Leone, A.K.3
  • 66
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008; 453: 620-625.
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 67
    • 77951238012 scopus 로고    scopus 로고
    • Beneficial effects of Bacteroides fragilis polysaccharides on the immune system
    • Troy EB, Kasper DL. Beneficial effects of Bacteroides fragilis polysaccharides on the immune system. Front Biosci 2010; 15: 25-34.
    • (2010) Front Biosci , vol.15 , pp. 25-34
    • Troy, E.B.1    Kasper, D.L.2
  • 68
    • 84884379881 scopus 로고    scopus 로고
    • Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection
    • Perez-Santiago J, Gianella S, Massanella M, et al. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS 2013; 27: 1921-1931.
    • (2013) AIDS , vol.27 , pp. 1921-1931
    • Perez-Santiago, J.1    Gianella, S.2    Massanella, M.3
  • 69
    • 84873369889 scopus 로고    scopus 로고
    • Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    • Klatt NR, Canary LA, Sun X, et al. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. J Clin Invest 2013; 123: 903-907.
    • (2013) J Clin Invest , vol.123 , pp. 903-907
    • Klatt, N.R.1    Canary, L.A.2    Sun, X.3
  • 70
    • 84874963999 scopus 로고    scopus 로고
    • Bacteria as vitamin suppliers to their host: A gut microbiota perspective
    • LeBlanc JG, Milani C, de Giori GS, et al. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol 2013; 24: 160-168.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 160-168
    • LeBlanc, J.G.1    Milani, C.2    De Giori, G.S.3
  • 71
    • 63849241608 scopus 로고    scopus 로고
    • Diversity, metabolism and microbial ecology of butyrateproducing bacteria from the human large intestine
    • Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrateproducing bacteria from the human large intestine. FEMS Microbiol Lett 2009; 294: 1-8.
    • (2009) FEMS Microbiol Lett , vol.294 , pp. 1-8
    • Louis, P.1    Flint, H.J.2
  • 72
    • 77954566982 scopus 로고    scopus 로고
    • Dissecting the in vivo metabolic potential of two human gut acetogens
    • Rey FE, Faith JJ, Bain J, et al. Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem 2010; 285: 22082-22090.
    • (2010) J Biol Chem , vol.285 , pp. 22082-22090
    • Rey, F.E.1    Faith, J.J.2    Bain, J.3
  • 73
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-termdietary patterns with gut microbial enterotypes
    • WuGD, Chen J, Hoffmann C, et al. Linking long-termdietary patterns with gut microbial enterotypes. Science 2011; 334: 105-108.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3
  • 74
    • 84924375353 scopus 로고    scopus 로고
    • HIV-induced alteration in gut microbiota: Driving factors, consequences, and effects of antiretroviral therapy
    • Lozupone CA, Rhodes ME, Neff CP, et al. HIV-induced alteration in gut microbiota: driving factors, consequences, and effects of antiretroviral therapy. Gut Microbes 2014; 5: 562-570.
    • (2014) Gut Microbes , vol.5 , pp. 562-570
    • Lozupone, C.A.1    Rhodes, M.E.2    Neff, C.P.3
  • 75
    • 84932619244 scopus 로고    scopus 로고
    • Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals
    • Vazquez-Castellanos JF, Serrano-Villar S, Latorre A, et al. Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunol 2015; 8: 760-772.
    • (2015) Mucosal Immunol , vol.8 , pp. 760-772
    • Vazquez-Castellanos, J.F.1    Serrano-Villar, S.2    Latorre, A.3
  • 76
    • 84928890301 scopus 로고    scopus 로고
    • Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children
    • Guandalini S, Cernat E, Moscoso D. Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children. Benef Microbes 2014; 6: 209-217.
    • (2014) Benef Microbes , vol.6 , pp. 209-217
    • Guandalini, S.1    Cernat, E.2    Moscoso, D.3
  • 77
    • 84912102518 scopus 로고    scopus 로고
    • Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
    • Tojo R, Suarez A, Clemente MG, et al. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol 2014; 20: 15163-15176.
    • (2014) World J Gastroenterol , vol.20 , pp. 15163-15176
    • Tojo, R.1    Suarez, A.2    Clemente, M.G.3
  • 78
    • 84922021717 scopus 로고    scopus 로고
    • Lactobacilli and bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model
    • Kandasamy S, Chattha KS, Vlasova AN, et al. Lactobacilli and bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model. Gut Microbes 2014; 5: 639-651.
    • (2014) Gut Microbes , vol.5 , pp. 639-651
    • Kandasamy, S.1    Chattha, K.S.2    Vlasova, A.N.3
  • 79
    • 54049101671 scopus 로고    scopus 로고
    • Manipulation of intestinal microbial flora for therapeutic benefit in inflammatory bowel diseases: Review of clinical trials of probiotics, prebiotics and synbiotics
    • Heilpern D, Szilagyi A. Manipulation of intestinal microbial flora for therapeutic benefit in inflammatory bowel diseases: review of clinical trials of probiotics, prebiotics and synbiotics. Rev Recent Clin Trials 2008; 3: 167-184.
    • (2008) Rev Recent Clin Trials , vol.3 , pp. 167-184
    • Heilpern, D.1    Szilagyi, A.2
  • 80
    • 84878961258 scopus 로고    scopus 로고
    • Gram-positive anaerobic cocci: Commensals and opportunistic pathogens
    • Murphy EC, Frick IM. Gram-positive anaerobic cocci: commensals and opportunistic pathogens. FEMS Microbiol Rev 2013; 37: 520-553.
    • (2013) FEMS Microbiol Rev , vol.37 , pp. 520-553
    • Murphy, E.C.1    Frick, I.M.2
  • 81
    • 84892956435 scopus 로고    scopus 로고
    • EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin
    • Kumar P, Luo Q, Vickers TJ, et al. EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin. Infect Immun 2014; 82: 500-508.
    • (2014) Infect Immun , vol.82 , pp. 500-508
    • Kumar, P.1    Luo, Q.2    Vickers, T.J.3
  • 82
    • 84355163059 scopus 로고    scopus 로고
    • Abundance and diversity of mucosaassociated hydrogenotrophic microbes in the healthy human colon
    • Nava GM, Carbonero F, Croix JA, et al. Abundance and diversity of mucosaassociated hydrogenotrophic microbes in the healthy human colon. ISME J 2012; 6: 57-70.
    • (2012) ISME J , vol.6 , pp. 57-70
    • Nava, G.M.1    Carbonero, F.2    Croix, J.A.3
  • 83
    • 0032718594 scopus 로고    scopus 로고
    • Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa
    • Levitt MD, Furne J, Springfield J, et al. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest 1999; 104: 1107-1114.
    • (1999) J Clin Invest , vol.104 , pp. 1107-1114
    • Levitt, M.D.1    Furne, J.2    Springfield, J.3
  • 84
    • 0036285079 scopus 로고    scopus 로고
    • Sulfate-reducing bacteria in human feces and their association with infammatory bowel diseases
    • Loubinoux J, Bronowicki JP, Pereira IAC, et al. Sulfate-reducing bacteria in human feces and their association with infammatory bowel diseases. FEMS Microbiol Ecol 2002; 40: 107-112.
    • (2002) FEMS Microbiol Ecol , vol.40 , pp. 107-112
    • Loubinoux, J.1    Bronowicki, J.P.2    Pereira, I.A.C.3
  • 85
    • 84867521316 scopus 로고    scopus 로고
    • Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome
    • Handley SA, Thackray LB, Zhao G, et al. Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. Cell 2012; 151: 253-266.
    • (2012) Cell , vol.151 , pp. 253-266
    • Handley, S.A.1    Thackray, L.B.2    Zhao, G.3
  • 86
    • 84897392010 scopus 로고    scopus 로고
    • Oral mycobiome analysis of HIVinfected patients: Identification of Pichia as an antagonist of opportunistic fungi
    • Mukherjee PK, Chandra J, Retuerto M, et al. Oral mycobiome analysis of HIVinfected patients: identification of Pichia as an antagonist of opportunistic fungi. PLoS Pathog 2014; 10: e1003996.
    • (2014) PLoS Pathog , vol.10 , pp. e1003996
    • Mukherjee, P.K.1    Chandra, J.2    Retuerto, M.3
  • 87
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179: 859-870.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3
  • 88
    • 0038701685 scopus 로고    scopus 로고
    • T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187: 1534-1543.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 89
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2, 3- dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, Mold J, Hunt PW, et al. Tryptophan catabolism by indoleamine 2, 3- dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010; 2: 32ra36.
    • (2010) Sci Transl Med , vol.2 , pp. 32ra36
    • Favre, D.1    Mold, J.2    Hunt, P.W.3
  • 90
    • 84866555781 scopus 로고    scopus 로고
    • Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
    • Klatt NR, Estes JD, Sun X, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol 2012; 5: 646-657.
    • (2012) Mucosal Immunol , vol.5 , pp. 646-657
    • Klatt, N.R.1    Estes, J.D.2    Sun, X.3
  • 92
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 2008; 112: 2826-2835.
    • (2008) Blood , vol.112 , pp. 2826-2835
    • Brenchley, J.M.1    Paiardini, M.2    Knox, K.S.3
  • 93
    • 84953291096 scopus 로고    scopus 로고
    • Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection
    • Dillon SM, Lee EJ, Kotter CV, et al. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection. Mucosal Immunol 2015. doi: 10.1038/mi.2015.33.
    • (2015) Mucosal Immunol
    • Dillon, S.M.1    Lee, E.J.2    Kotter, C.V.3
  • 94
    • 84859164917 scopus 로고    scopus 로고
    • Homeland security: IgA immunity at the frontiers of the body
    • Macpherson AJ, Geuking MB, McCoy KD. Homeland security: IgA immunity at the frontiers of the body. Trends Immunol 2012; 33: 160-167.
    • (2012) Trends Immunol , vol.33 , pp. 160-167
    • Macpherson, A.J.1    Geuking, M.B.2    McCoy, K.D.3
  • 95
    • 84939570686 scopus 로고    scopus 로고
    • The bilateral responsiveness between intestinal microbes and IgA
    • Macpherson AJ, Koller Y, McCoy KD. The bilateral responsiveness between intestinal microbes and IgA. Trends Immunol 2015; 36: 460-470.
    • (2015) Trends Immunol , vol.36 , pp. 460-470
    • Macpherson, A.J.1    Koller, Y.2    McCoy, K.D.3
  • 96
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science 2012; 336: 1268-1273.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 97
    • 84919949772 scopus 로고    scopus 로고
    • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria
    • Trama AM, Moody MA, Alam SM, et al. HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host Microbe 2014; 16: 215-226.
    • (2014) Cell Host Microbe , vol.16 , pp. 215-226
    • Trama, A.M.1    Moody, M.A.2    Alam, S.M.3
  • 98
    • 84904688744 scopus 로고    scopus 로고
    • HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in southern Africa are primarily directed toward gp120 and gp140 specificities
    • Seaton KE, Ballweber L, Lan A, et al. HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in southern Africa are primarily directed toward gp120 and gp140 specificities. PLoS One 2014; 9: e101863.
    • (2014) PLoS One , vol.9 , pp. e101863
    • Seaton, K.E.1    Ballweber, L.2    Lan, A.3
  • 99
    • 84932620359 scopus 로고    scopus 로고
    • Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization
    • Jee J, Bonnegarde-Bernard A, Duverger A, et al. Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization. Mucosal Immunol 2015; 8: 735-745.
    • (2015) Mucosal Immunol , vol.8 , pp. 735-745
    • Jee, J.1    Bonnegarde-Bernard, A.2    Duverger, A.3
  • 100
    • 83855165652 scopus 로고    scopus 로고
    • Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa
    • Bron PA, van Baarlen P, Kleerebezem M. Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nat Rev Microbiol 2012; 10: 66-78.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 66-78
    • Bron, P.A.1    Van Baarlen, P.2    Kleerebezem, M.3
  • 101
    • 84945545407 scopus 로고    scopus 로고
    • Probiotics reduce inflammation in antiretroviral treated, HIV-infected individuals: Results of the 'Probio-HIV' clinical trial
    • d'Ettorre G, Ceccarelli G, Giustini N, et al. Probiotics reduce inflammation in antiretroviral treated, HIV-infected individuals: results of the 'Probio-HIV' clinical trial. PLoS One 2015; 10: e0137200.
    • (2015) PLoS One , vol.10 , pp. e0137200
    • D'Ettorre, G.1    Ceccarelli, G.2    Giustini, N.3
  • 102
    • 84923642248 scopus 로고    scopus 로고
    • Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients - A double-blind, randomized, placebo-controlled trial
    • Villar-Garcia J, Hernandez JJ, Guerri-Fernandez R, et al. Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients -a double-blind, randomized, placebo-controlled trial. J Acquir Immune Defic Syndr 2015; 68: 256-263.
    • (2015) J Acquir Immune Defic Syndr , vol.68 , pp. 256-263
    • Villar-Garcia, J.1    Hernandez, J.J.2    Guerri-Fernandez, R.3
  • 103
    • 84860390171 scopus 로고    scopus 로고
    • Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: Results of the 'COPA' pilot randomized trial
    • Gori A, Rizzardini G, Van 't Land B, et al. Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the 'COPA' pilot randomized trial. Mucosal Immunol 2011; 4: 554-563.
    • (2011) Mucosal Immunol , vol.4 , pp. 554-563
    • Gori, A.1    Rizzardini, G.2    Van'T Land, B.3
  • 104
    • 84961806957 scopus 로고    scopus 로고
    • IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques
    • Ortiz AM, Klase ZA, DiNapoli SR, et al. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol 2015. doi: 10.1038/mi.2015.75.
    • (2015) Mucosal Immunol
    • Ortiz, A.M.1    Klase, Z.A.2    DiNapoli, S.R.3
  • 105
    • 84902124658 scopus 로고    scopus 로고
    • Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication
    • Kristoff J, Haret-Richter G, Ma D, et al. Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. J Clin Invest 2014; 124: 2802-2806.
    • (2014) J Clin Invest , vol.124 , pp. 2802-2806
    • Kristoff, J.1    Haret-Richter, G.2    Ma, D.3
  • 106
    • 84912144937 scopus 로고    scopus 로고
    • Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection
    • Sandler NG, Zhang X, Bosch RJ, et al. Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection. J Infect Dis 2014; 210: 1549-1554.
    • (2014) J Infect Dis , vol.210 , pp. 1549-1554
    • Sandler, N.G.1    Zhang, X.2    Bosch, R.J.3
  • 107
    • 80054739868 scopus 로고    scopus 로고
    • Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: A randomized controlled trial
    • Byakwaga H, Kelly M, Purcell DF, et al. Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial. J Infect Dis 2011; 204: 1532-1540.
    • (2011) J Infect Dis , vol.204 , pp. 1532-1540
    • Byakwaga, H.1    Kelly, M.2    Purcell, D.F.3
  • 108
    • 84860584561 scopus 로고    scopus 로고
    • PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
    • Dyavar Shetty R, Velu V, Titanji K, et al. PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. J Clin Invest 2012; 122: 1712-1716.
    • (2012) J Clin Invest , vol.122 , pp. 1712-1716
    • Dyavar Shetty, R.1    Velu, V.2    Titanji, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.