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Volumn 202, Issue 5, 2010, Pages 723-733

Persistent microbial translocation and immune activation in HIV-1-infected south africans receiving combination antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; EFAVIRENZ; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; LAMIVUDINE; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEVIRAPINE; STAVUDINE; TUMOR NECROSIS FACTOR;

EID: 77955690397     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/655229     Document Type: Article
Times cited : (177)

References (49)
  • 1
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-870.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3
  • 2
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    • Hazenberg MD, Otto SA, van Benthem BH, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003; 17:1881-1888.
    • (2003) AIDS , vol.17 , pp. 1881-1888
    • Hazenberg, M.D.1    Otto, S.A.2    Van Benthem, B.H.3
  • 3
    • 0034767911 scopus 로고    scopus 로고
    • Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection
    • Lawn SD, Butera ST, Folks TM. Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. Clin Microbiol Rev 2001; 14:753-777.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 753-777
    • Lawn, S.D.1    Butera, S.T.2    Folks, T.M.3
  • 5
    • 0031873061 scopus 로고    scopus 로고
    • Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals
    • Zangerle R, Steinhuber S, Sarcletti M, et al. Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals. Int Arch Allergy Immunol 1998; 116:228-239.
    • (1998) Int Arch Allergy Immunol , vol.116 , pp. 228-239
    • Zangerle, R.1    Steinhuber, S.2    Sarcletti, M.3
  • 6
    • 34248512907 scopus 로고    scopus 로고
    • HIV suppression byHAART preserves cognitive function in advanced, immune-reconstituted AIDS patients
    • McCutchan JA,Wu JW, Robertson K, et al. HIV suppression byHAART preserves cognitive function in advanced, immune-reconstituted AIDS patients. AIDS 2007; 21:1109-1117.
    • (2007) AIDS , vol.21 , pp. 1109-1117
    • McCutchan, J.A.1    Wu, J.W.2    Robertson, K.3
  • 7
    • 0038701685 scopus 로고    scopus 로고
    • T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virusinfected patients with sustained viral suppression during antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virusinfected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187:1534-1543.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 8
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199:1177-1185.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 9
    • 75349114036 scopus 로고    scopus 로고
    • Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy
    • Deeks SG. Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med 2009; 17:118-123.
    • (2009) Top HIV Med , vol.17 , pp. 118-123
    • Deeks, S.G.1
  • 10
    • 62449222132 scopus 로고    scopus 로고
    • Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment
    • Kelley CF, Kitchen CM, Hunt PW, et al. Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin Infect Dis 2009; 48:787-794.
    • (2009) Clin Infect Dis , vol.48 , pp. 787-794
    • Kelley, C.F.1    Kitchen, C.M.2    Hunt, P.W.3
  • 11
    • 33846439783 scopus 로고    scopus 로고
    • CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression
    • Moore RD, Keruly JC. CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis 2007; 44:441-446.
    • (2007) Clin Infect Dis , vol.44 , pp. 441-446
    • Moore, R.D.1    Keruly, J.C.2
  • 12
    • 10744227881 scopus 로고    scopus 로고
    • CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: The Swiss HIV Cohort Study
    • Kaufmann GR, Perrin L, Pantaleo G, et al. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study. Arch Intern Med 2003; 163:2187-2195.
    • (2003) Arch Intern Med , vol.163 , pp. 2187-2195
    • Kaufmann, G.R.1    Perrin, L.2    Pantaleo, G.3
  • 13
    • 42449086328 scopus 로고    scopus 로고
    • CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
    • Baker JV, Peng G, Rapkin J, et al. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS 2008; 22: 841-848.
    • (2008) AIDS , vol.22 , pp. 841-848
    • Baker, J.V.1    Peng, G.2    Rapkin, J.3
  • 15
    • 67650152516 scopus 로고    scopus 로고
    • M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms
    • Cassol E, Cassetta L, Rizzi C, Alfano M, Poli G. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J Immunol 2009; 182:6237-6246.
    • (2009) J Immunol , vol.182 , pp. 6237-6246
    • Cassol, E.1    Cassetta, L.2    Rizzi, C.3    Alfano, M.4    Poli, G.5
  • 16
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009; 86:1065-1073.
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 17
    • 34047258169 scopus 로고    scopus 로고
    • Cellular mechanisms in sepsis
    • Jean-Baptiste E. Cellular mechanisms in sepsis. J Intensive Care Med 2007; 22:63-72.
    • (2007) J Intensive Care Med , vol.22 , pp. 63-72
    • Jean-Baptiste, E.1
  • 18
    • 67649784384 scopus 로고    scopus 로고
    • Innate immunity in inflammatory bowel disease: State of the art
    • Hisamatsu T, Ogata H, Hibi T. Innate immunity in inflammatory bowel disease: state of the art. Curr Opin Gastroenterol 2008; 24:448-454.
    • (2008) Curr Opin Gastroenterol , vol.24 , pp. 448-454
    • Hisamatsu, T.1    Ogata, H.2    Hibi, T.3
  • 19
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 20
    • 33645924682 scopus 로고    scopus 로고
    • HIV disease: Fallout from a mucosal catastrophe?
    • Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006; 7:235-239.
    • (2006) Nat Immunol , vol.7 , pp. 235-239
    • Brenchley, J.M.1    Price, D.A.2    Douek, D.C.3
  • 21
    • 49649129676 scopus 로고    scopus 로고
    • Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients
    • Ancuta P, Kamat A, Kunstman KJ, et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One 2008; 3:e2516.
    • (2008) PLoS One , vol.3
    • Ancuta, P.1    Kamat, A.2    Kunstman, K.J.3
  • 22
    • 53549129725 scopus 로고    scopus 로고
    • Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIVinfected patients on long-term highly active antiretroviral therapy
    • Marchetti G, Bellistri GM, Borghi E, et al. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIVinfected patients on long-term highly active antiretroviral therapy. AIDS 2008; 22:2035-2038.
    • (2008) AIDS , vol.22 , pp. 2035-2038
    • Marchetti, G.1    Bellistri, G.M.2    Borghi, E.3
  • 23
    • 46049084182 scopus 로고    scopus 로고
    • Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
    • Balagopal A, Philp FH, Astemborski J, et al. Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology 2008; 135:226-233.
    • (2008) Gastroenterology , vol.135 , pp. 226-233
    • Balagopal, A.1    Philp, F.H.2    Astemborski, J.3
  • 24
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • Hunt PW, Brenchley J, Sinclair E, et al. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008; 197:126-133.
    • (2008) J Infect Dis , vol.197 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3
  • 25
    • 66149099672 scopus 로고    scopus 로고
    • Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa
    • Redd AD, Dabitao D, Bream JH, et al. Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proc Natl Acad Sci U S A 2009; 106:6718-6723.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6718-6723
    • Redd, A.D.1    Dabitao, D.2    Bream, J.H.3
  • 26
    • 66249085573 scopus 로고    scopus 로고
    • HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers
    • Lester RT, Yao XD, Ball TB, et al. HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers. PLoS One 2009; 4:e5644.
    • (2009) PLoS One , vol.4
    • Lester, R.T.1    Yao, X.D.2    Ball, T.B.3
  • 27
    • 71549143183 scopus 로고    scopus 로고
    • Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with<50copies/ml HIV-1 RNA
    • Baroncelli S, Galluzzo CM, Pirillo MF, et al. Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with<50copies/ml HIV-1 RNA. J Clin Virol 2009; 46:367-370.
    • (2009) J Clin Virol , vol.46 , pp. 367-370
    • Baroncelli, S.1    Galluzzo, C.M.2    Pirillo, M.F.3
  • 28
    • 70349319715 scopus 로고    scopus 로고
    • Targeting IL-6 in the treatment of inflammatory and autoimmune diseases
    • Ding C, Cicuttini F, Li J, Jones G. Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert Opin Investig Drugs 2009; 18:1457-1466.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1457-1466
    • Ding, C.1    Cicuttini, F.2    Li, J.3    Jones, G.4
  • 30
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • Biswas SK, Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 2009; 30:475-487.
    • (2009) Trends Immunol , vol.30 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 31
    • 25444474430 scopus 로고    scopus 로고
    • Modulatory effects of sCD14 and LBP on LPS-host cell interactions
    • Kitchens RL, Thompson PA. Modulatory effects of sCD14 and LBP on LPS-host cell interactions. J Endotoxin Res 2005; 11:225-229.
    • (2005) J Endotoxin Res , vol.11 , pp. 225-229
    • Kitchens, R.L.1    Thompson, P.A.2
  • 32
    • 0034898389 scopus 로고    scopus 로고
    • Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins
    • Kitchens RL, Thompson PA, Viriyakosol S, O'Keefe GE, Munford RS. Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins. J Clin Invest 2001; 108:485-493.
    • (2001) J Clin Invest , vol.108 , pp. 485-493
    • Kitchens, R.L.1    Thompson, P.A.2    Viriyakosol, S.3    O'Keefe, G.E.4    Munford, R.S.5
  • 33
    • 0033607808 scopus 로고    scopus 로고
    • Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface
    • Kitchens RL, Wolfbauer G, Albers JJ, Munford RS. Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface. J Biol Chem 1999; 274:34116-34122.
    • (1999) J Biol Chem , vol.274 , pp. 34116-34122
    • Kitchens, R.L.1    Wolfbauer, G.2    Albers, J.J.3    Munford, R.S.4
  • 34
    • 0028232001 scopus 로고
    • Plasma lipids in HIV-infected patients: A prospective study in 95 patients
    • Constans J, Pellegrin JL, Peuchant E, et al. Plasma lipids in HIV-infected patients: a prospective study in 95 patients. Eur J Clin Invest 1994; 24:416-420.
    • (1994) Eur J Clin Invest , vol.24 , pp. 416-420
    • Constans, J.1    Pellegrin, J.L.2    Peuchant, E.3
  • 35
    • 13944282127 scopus 로고    scopus 로고
    • Chlamydia pneumoniae infection in HIV-positive patients: Prevalence and relationship with lipid profile
    • Tositti G, Rassu M, Fabris P, et al. Chlamydia pneumoniae infection in HIV-positive patients: prevalence and relationship with lipid profile. HIV Med 2005; 6:27-32.
    • (2005) HIV Med , vol.6 , pp. 27-32
    • Tositti, G.1    Rassu, M.2    Fabris, P.3
  • 36
    • 0029414974 scopus 로고
    • CD14lowCD16high: A cytokine-producing monocyte subset which expands during human immunodeficiency virus infection
    • Thieblemont N, Weiss L, Sadeghi HM, Estcourt C, Haeffner-Cavaillon N. CD14lowCD16high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection. Eur J Immunol 1995; 25:3418-3424.
    • (1995) Eur J Immunol , vol.25 , pp. 3418-3424
    • Thieblemont, N.1    Weiss, L.2    Sadeghi, H.M.3    Estcourt, C.4    Haeffner-Cavaillon, N.5
  • 37
    • 9644302604 scopus 로고    scopus 로고
    • Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load
    • Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol 2004; 157:93-98.
    • (2004) J Neuroimmunol , vol.157 , pp. 93-98
    • Pulliam, L.1    Sun, B.2    Rempel, H.3
  • 38
    • 34248162439 scopus 로고    scopus 로고
    • The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo
    • Ellery PJ, Tippett E, Chiu YL, et al. The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo. J Immunol 2007; 178:6581-6589.
    • (2007) J Immunol , vol.178 , pp. 6581-6589
    • Ellery, P.J.1    Tippett, E.2    Chiu, Y.L.3
  • 39
    • 12144260890 scopus 로고    scopus 로고
    • Circulating proviral HIV DNA and HIV-associated dementia
    • Shiramizu B, Gartner S, Williams A, et al. Circulating proviral HIV DNA and HIV-associated dementia. AIDS 2005; 19:45-52.
    • (2005) AIDS , vol.19 , pp. 45-52
    • Shiramizu, B.1    Gartner, S.2    Williams, A.3
  • 41
    • 0034723366 scopus 로고    scopus 로고
    • HIV infection and dementia
    • Gartner S. HIV infection and dementia. Science 2000; 287:602-604.
    • (2000) Science , vol.287 , pp. 602-604
    • Gartner, S.1
  • 43
    • 0035912198 scopus 로고    scopus 로고
    • Pathways to neuronal injury and apoptosis in HIV-associated dementia
    • Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001; 410:988-994.
    • (2001) Nature , vol.410 , pp. 988-994
    • Kaul, M.1    Garden, G.A.2    Lipton, S.A.3
  • 44
    • 30044452345 scopus 로고    scopus 로고
    • CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells
    • Ancuta P, Kunstman KJ, Autissier P, et al. CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells. Virology 2006; 344: 267-276.
    • (2006) Virology , vol.344 , pp. 267-276
    • Ancuta, P.1    Kunstman, K.J.2    Autissier, P.3
  • 45
    • 33646492298 scopus 로고    scopus 로고
    • CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands
    • Ancuta P, Autissier P,Wurcel A, Zaman T, Stone D, Gabuzda D. CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J Immunol 2006; 176: 5760-5771.
    • (2006) J Immunol , vol.176 , pp. 5760-5771
    • Ancuta, P.1    Autissier, P.2    Wurcel, A.3    Zaman, T.4    Stone, D.5    Gabuzda, D.6
  • 46
    • 0028070573 scopus 로고
    • Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens
    • Denis M, Ghadirian E. Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens. Clin Exp Immunol 1994; 97:76-82.
    • (1994) Clin Exp Immunol , vol.97 , pp. 76-82
    • Denis, M.1    Ghadirian, E.2
  • 47
    • 0031802440 scopus 로고    scopus 로고
    • Proinflammatory cytokine and human immunodeficiency virus RNA levels during early Mycobacterium avium complex bacteremia in advanced AIDS
    • Haas DW, Lederman MM, Clough LA, Wallis RS, Chernoff D, Crampton SL. Proinflammatory cytokine and human immunodeficiency virus RNA levels during early Mycobacterium avium complex bacteremia in advanced AIDS. J Infect Dis 1998; 177:1746-1749.
    • (1998) J Infect Dis , vol.177 , pp. 1746-1749
    • Haas, D.W.1    Lederman, M.M.2    Clough, L.A.3    Wallis, R.S.4    Chernoff, D.5    Crampton, S.L.6
  • 48
    • 0036184719 scopus 로고    scopus 로고
    • Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration disease after HAART
    • Stone SF, Price P, Keane NM, Murray RJ, French MA. Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration disease after HAART. HIV Med 2002; 3:21-27.
    • (2002) HIV Med , vol.3 , pp. 21-27
    • Stone, S.F.1    Price, P.2    Keane, N.M.3    Murray, R.J.4    French, M.A.5
  • 49
    • 27644489746 scopus 로고    scopus 로고
    • Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    • Emu B, Sinclair E, Favre D, et al. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005; 79:14169-14178.
    • (2005) J Virol , vol.79 , pp. 14169-14178
    • Emu, B.1    Sinclair, E.2    Favre, D.3


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