Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children

Beneficial Microbes

Volumn 6, Issue 2, 2015, Pages 209-217

  Guandalini, S ^a   Cernat, E ^a   Moscoso, D ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Crohn's disease; Functional gastrointestinal disorders; Inflammatory bowel disease; Irritable bowel syndrome; Ulcerative colitis

Indexed keywords

FRUCTOSE OLYGOSACCHARIDE; GALACTO OLYGOSACCHARIDE; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADOLESCENT; ADULT; BLOATING; CHILD; CONSTIPATION; CROHN DISEASE; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG EFFICACY; FECES ANALYSIS; FLATULENCE; GASTROINTESTINAL MOTILITY; HUMAN; ILEITIS; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; IRRITABLE COLON; LOW DRUG DOSE; META ANALYSIS; MOUSE; NONHUMAN; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RAT; RELAPSE; REMISSION; REVIEW; SAMPLE SIZE; SOCIAL INTERACTION; SOCIAL PSYCHOLOGY; SYMPTOMATOLOGY; ULCERATIVE COLITIS; INFLAMMATORY BOWEL DISEASES; IRRITABLE BOWEL SYNDROME; PRESCHOOL CHILD;

CHILD; CHILD, PRESCHOOL; HUMANS; INFLAMMATORY BOWEL DISEASES; IRRITABLE BOWEL SYNDROME; PREBIOTICS; PROBIOTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84928890301     PISSN: 18762883     EISSN: 18762891     Source Type: Journal    
DOI: 10.3920/BM2014.0067     Document Type: Review

References (85)

1. Amit-Romach, E., Uni, Z. and Reifen, R., 2008. Therapeutic potential of two probiotics in inflammatory bowel disease as observed in the trinitrobenzene sulfonic acid model of colitis. Diseases of the Colon and Rectum 51: 1828-1836.
2. Araki, Y., Kanauchi, O., Sugihara, H., Fujiyama, Y. and Hattori, T., 2007. Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: the role of mast cells. International Journal of Molecular Medicine 19: 257-262.
3. Bamba, T., Kanauchi, O., Andoh, A. and Fujiyama, Y., 2002. A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis. Journal of Gastroenterology and Hepatology 17: 818-824.
4. Banaszkiewicz, A. and Szajewska, H., 2005. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. Journal of Pediatrics 146: 364-369.
5. Bausserman, M. and Michail, S., 2005. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. Journal of Pediatrics 147: 197-201.
6. Benjamin, J.L., Hedin, C.R., Koutsoumpas, A., Ng, S.C., McCarthy, N.E., Hart, A.L., Kamm, M.A., Sanderson, J.D., Knight, S.C., Forbes, A., Stagg, A.J., Whelan, K. and Lindsay, J.O., 2011. Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut 60: 923-929.
7. Biancone, L., Calabrese, E., Petruzziello, C. and Pallone, F., 2007. Treatment with biologic therapies and the risk of cancer in patients with IBD. Nature Clinical Practice: Gastroenterology & Hepatology 4: 78-91.
8. Bourreille, A., Cadiot, G., Le Dreau, G., Laharie, D., Beaugerie, L., Dupas, J.L., Marteau, P., Rampal, P., Moyse, D., Saleh, A., Le Guern, M.E. and Galmiche, J.P., 2013. Saccharomyces boulardii does not prevent relapse of Crohn's disease. Clinical Gastroenterology and Hepatology 11: 982-987.
9. Bousvaros, A., Guandalini, S., Baldassano, R.N., Botelho, C., Evans, J., Ferry, G.D., Goldin, B., Hartigan, L., Kugathasan, S., Levy, J., Murray, K.F., Oliva-Hemker, M., Rosh, J.R., Tolia, V., Zholudev, A., Vanderhoof, J.A. and Hibberd, P.L., 2005. A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease. Inflammatory Bowel Diseases 11: 833-839.
10. Bovee-Oudenhoven, I.M., ten Bruggencate, S.J., Lettink-Wissink, M.L. and van der Meer, R., 2003. Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of Salmonella in rats. Gut 52: 1572-1578.
11. Bu, L.N., Chang, M.H., Ni, Y.H., Chen, H.L. and Cheng, C.C., 2007. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatrics International 49: 485-490.
12. Camilleri, M., 2001. Management of the irritable bowel syndrome. Gastroenterology 120: 652-668.
13. Carroll, I.M., Ringel-Kulka, T., Siddle, J.P. and Ringel, Y., 2012. Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterology and Motility 24: 521-530, e248.
14. Casellas, F., Borruel, N., Torrejon, A., Varela, E., Antolin, M., Guarner, F. and Malagelada, J.R., 2007. Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin. Alimentary Pharmacology and Therapeutics 25: 1061-1067.
15. Chen, L.L., Wang, X.H., Cui, Y., Lian, G.H., Zhang, J., Ouyang, C.H. and Lu, F.G., 2009. Therapeutic effects of four strains of probiotics on experimental colitis in mice. World Journal of Gastroenterology 15: 321-327.
16. Chung, Y.W., Choi, J.H., Oh, T.Y., Eun, C.S. and Han, D.S., 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clinical and Experimental Immunology 151: 182-189.
17. Collins, S.M., Surette, M. and Bercik, P., 2012. The interplay between the intestinal microbiota and the brain. Nature Reviews Microbiology 10: 735-742.
18. Dai, C., Zheng, C.Q., Meng, F.J., Zhou, Z., Sang, L.X. and Jiang, M., 2013. VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-kappaB pathway in rat model of DSS-induced colitis. Molecular and Cellular Biochemistry 374: 1-11.
19. De Greef, E., Vandenplas, Y., Hauser, B., Devreker, T. and Veereman-Wauters, G., 2013. Probiotics and IBD. Acta Gastroenterologica Belgica 76: 15-19.
20. De Vries, H.S., Van Oijen, M.G. and De Jong, D.J., 2008. Serious events with infliximab in patients with inflammatory bowel disease: a 9-year cohort study in the Netherlands. Drug Safety 31: 1135-1144.
21. Dicksved, J., Halfvarson, J., Rosenquist, M., Jarnerot, G., Tysk, C., Apajalahti, J., Engstrand, L. and Jansson, J.K., 2008. Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME Journal 2: 716-727.
22. DuPont, H.L., 2014. Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets. Alimentary Pharmacology and Therapeutics 39: 1033-1042.
23. Everhart, J.E. and Renault, P.F., 1991. Irritable bowel syndrome in officebased practice in the United States. Gastroenterology 100: 998-1005.
24. Feighery, L.M., Smith, P., O'Mahony, L., Fallon, P.G. and Brayden, D.J., 2008. Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease. Digestive Diseases and Sciences 53: 2495-2506.
25. Fitzpatrick, L.R., Hertzog, K.L., Quatse, A.L., Koltun, W.A., Small, J.S. and Vrana, K., 2007. Effects of the probiotic formulation VSL#3 on colitis in weanling rats. Journal of Pediatric Gastroenterology and Nutrition 44: 561-570.
26. Fitzpatrick, L.R., Small, J., Hoerr, R.A., Bostwick, E.F., Maines, L. and Koltun, W.A., 2008. In vitro and in vivo effects of the probiotic Escherichia coli strain M-17: immunomodulation and attenuation of murine colitis. British Journal of Nutrition 100: 530-541.
27. Francavilla, R., Lionetti, E., Castellaneta, S., Ciruzzi, F., Indrio, F., Masciale, A., Fontana, C., La Rosa, M.M., Cavallo, L. and Francavilla, A., 2012. Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea-a double-blind study. Alimentary Pharmacology and Therapeutics 36: 363-369.
28. Francavilla, R., Miniello, V., Magista, A.M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., Indrio, F. and Cavallo, L., 2010. A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain. Pediatrics 126: e1445-1452.
29. Fukuda, M., Kanauchi, O., Araki, Y., Andoh, A., Mitsuyama, K., Takagi, K., Toyonaga, A., Sata, M., Fujiyama, Y., Fukuoka, M., Matsumoto, Y. and Bamba, T., 2002. Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment. International Journal of Molecular Medicine 9: 65-70.
30. Gawronska, A., Dziechciarz, P., Horvath, A. and Szajewska, H., 2007. A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Alimentary Pharmacology and Therapeutics 25: 177-184.
31. Guandalini, S., Magazzu, G., Chiaro, A., La Balestra, V., Di Nardo, G., Gopalan, S., Sibal, A., Romano, C., Canani, R.B., Lionetti, P. and Setty, M., 2010. VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study. Journal of Pediatric Gastroenterology and Nutrition 51: 24-30.
32. Guerra, P.V., Lima, L.N., Souza, T.C., Mazochi, V., Penna, F.J., Silva, A.M., Nicoli, J.R. and Guimaraes, E.V., 2011. Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World Journal of Gastroenterology 17: 3916-3921.
33. Guslandi, M., Mezzi, G., Sorghi, M. and Testoni, P.A., 2000. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Digestive Diseases and Sciences 45: 1462-1464.
34. Hallert, C., Kaldma, M. and Petersson, B.G., 1991. Ispaghula husk may relieve gastrointestinal symptoms in ulcerative colitis in remission. Scandinavian Journal of Gastroenterology 26: 747-750.
35. Hoentjen, F., Welling, G.W., Harmsen, H.J., Zhang, X., Snart, J., Tannock, G.W., Lien, K., Churchill, T.A., Lupicki, M. and Dieleman, L.A., 2005. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflammatory Bowel Diseases 11: 977-985.
36. Huertas-Ceballos, A.A., Logan, S., Bennett, C. and Macarthur, C., 2009. Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Systematic Reviews: CD003019.
37. Hunter, J.O., Tuffnell, Q. and Lee, A.J., 1999. Controlled trial of oligofructose in the management of irritable bowel syndrome. Journal of Nutrition 129: 1451S-1453S.
38. Johnson, A.C., Greenwood-Van Meerveld, B. and McRorie, J., 2011. Effects of Bifidobacterium infantis 35624 on post-inflammatory visceral hypersensitivity in the rat. Digestive Diseases and Sciences 56: 3179-3186.
39. Jonkers, D., Penders, J., Masclee, A. and Pierik, M., 2012. Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients. Drugs 72: 803-823.
40. Kanauchi, O., Suga, T., Tochihara, M., Hibi, T., Naganuma, M., Homma, T., Asakura, H., Nakano, H., Takahama, K., Fujiyama, Y., Andoh, A., Shimoyama, T., Hida, N., Haruma, K., Koga, H., Mitsuyama, K., Sata, M., Fukuda, M., Kojima, A. and Bamba, T., 2002. Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial. Journal of Gastroenterology 37 Suppl. 14: 67-72.
41. Kassinen, A., Krogius-Kurikka, L., Makivuokko, H., Rinttila, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J. and Palva, A., 2007. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133: 24-33.
42. Korterink, J.J., Ockeloen, L., Benninga, M.A., Tabbers, M.M., Hilbink, M. and Deckers-Kocken, J.M., 2014. Probiotics for childhood functional gastrointestinal disorders: a systematic review and metaanalysis. Acta Paediatrica 103: 365-372.
43. Kruis, W., Chrubasik, S., Boehm, S., Stange, C. and Schulze, J., 2012. A double-blind placebo-controlled trial to study therapeutic effects of probiotic Escherichia coli Nissle 1917 in subgroups of patients with irritable bowel syndrome. International Journal of Colorectal Disease 27: 467-474.
44. Lee, H.S., Han, S.Y., Bae, E.A., Huh, C.S., Ahn, Y.T., Lee, J.H. and Kim, D.H., 2008. Lactic acid bacteria inhibit proinflammatory cytokine expression and bacterial glycosaminoglycan degradation activity in dextran sulfate sodium-induced colitic mice. International Immunopharmacology 8: 574-580.
45. Lindsay, J.O., Whelan, K., Stagg, A.J., Gobin, P., Al-Hassi, H.O., Rayment, N., Kamm, M.A., Knight, S.C. and Forbes, A., 2006. Clinical, microbiological, and immunological effects of fructooligosaccharide in patients with Crohn's disease. Gut 55: 348-355.
46. Lionetti, P., Callegari, M.L., Ferrari, S., Cavicchi, M.C., Pozzi, E., De Martino, M. and Morelli, L., 2005. Enteral nutrition and microflora in pediatric Crohn's disease. Journal of Parenteral and Enteral Nutrition 29: S173-S175; discussion S175-S178, S184-S178.
47. Longstreth, G.F., Thompson, W.G., Chey, W.D., Houghton, L.A., Mearin, F. and Spiller, R.C., 2006. Functional bowel disorders. Gastroenterology 130: 1480-1491.
48. Malchow, H.A., 1997. Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease? Journal of Clinical Gastroenterology 25: 653-658.
49. Marteau, P., Lemann, M., Seksik, P., Laharie, D., Colombel, J.F., Bouhnik, Y., Cadiot, G., Soule, J.C., Bourreille, A., Metman, E., Lerebours, E., Carbonnel, F., Dupas, J.L., Veyrac, M., Coffin, B., Moreau, J., Abitbol, V., Blum-Sperisen, S. and Mary, J.Y., 2006. Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial. Gut 55: 842-847.
50. Martinez, C., Antolin, M., Santos, J., Torrejon, A., Casellas, F., Borruel, N., Guarner, F. and Malagelada, J.R., 2008. Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission. American Journal of Gastroenterology 103: 643-648.
51. McFarland, L.V. and Dublin, S., 2008. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World Journal of Gastroenterology 14: 2650-2661.
52. Mennigen, R., Nolte, K., Rijcken, E., Utech, M., Loeffler, B., Senninger, N. and Bruewer, M., 2009. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. American Journal of Physiology Gastrointestinal and Liver Physiology 296: G1140-1149.
53. Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R.N. and Staiano, A., 2009. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. American Journal of Gastroenterology 104: 437-443.
54. Nanda Kumar, N.S., Balamurugan, R., Jayakanthan, K., Pulimood, A., Pugazhendhi, S. and Ramakrishna, B.S., 2008. Probiotic administration alters the gut flora and attenuates colitis in mice administered dextran sodium sulfate. Journal of Gastroenterology and Hepatology 23: 1834-1839.
55. Ng, S.C., Plamondon, S., Kamm, M.A., Hart, A.L., Al-Hassi, H.O., Guenther, T., Stagg, A.J. and Knight, S.C., 2010. Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. Inflammatory Bowel Diseases 16: 1286-1298.
56. Olesen, M. and Gudmand-Hoyer, E., 2000. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. American Journal of Clinical Nutrition 72: 1570-1575.
57. Oliva, S., Di Nardo, G., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., Cucchiara, S. and Stronati, L., 2012. Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis. Alimentary Pharmacology and Therapeutics 35: 327-334.
58. Ong, D.K., Mitchell, S.B., Barrett, J.S., Shepherd, S.J., Irving, P.M., Biesiekierski, J.R., Smith, S., Gibson, P.R. and Muir, J.G., 2010. Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome. Journal of Gastroenterology and Hepatology 25: 1366-1373.
59. Paineau, D., Payen, F., Panserieu, S., Coulombier, G., Sobaszek, A., Lartigau, I., Brabet, M., Galmiche, J.P., Tripodi, D., Sacher-Huvelin, S., Chapalain, V., Zourabichvili, O., Respondek, F., Wagner, A. and Bornet, F.R., 2008. The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders. British Journal of Nutrition 99: 311-318.
60. Peran, L., Camuesco, D., Comalada, M., Bailon, E., Henriksson, A., Xaus, J., Zarzuelo, A. and Galvez, J., 2007a. A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis. Journal of Applied Microbiology 103: 836-844.
61. Peran, L., Sierra, S., Comalada, M., Lara-Villoslada, F., Bailon, E., Nieto, A., Concha, A., Olivares, M., Zarzuelo, A., Xaus, J. and Galvez, J., 2007b. A comparative study of the preventative effects exerted by two probiotics, Lactobacillus reuteri and Lactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis. British Journal of Nutrition 97: 96-103.
62. Prantera, C., Scribano, M.L., Falasco, G., Andreoli, A. and Luzi, C., 2002. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut 51: 405-409.
63. Quigley, E.M. and Flourie, B., 2007. Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterology and Motility 19: 166-172.
64. Rasquin, A., Di Lorenzo, C., Forbes, D., Guiraldes, E., Hyams, J.S., Staiano, A. and Walker, L.S., 2006. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 130: 1527-1537.
65. Romano, C., Ferrau, V., Cavataio, F., Iacono, G., Spina, M., Lionetti, E., Comisi, F., Famiani, A. and Comito, D., 2010. Lactobacillus reuteri in children with functional abdominal pain (FAP). Journal of Paediatrics and Child Health, in press. DOI: http://dx.doi. org/10.1111/j.1440-1754.2010.01797.x
66. Saps, M., Pensabene, L., Di Martino, L., Staiano, A., Wechsler, J., Zheng, X. and Di Lorenzo, C., 2008. Post-infectious functional gastrointestinal disorders in children. Journal of Pediatrics 152: 812-816, 816 e811.
67. Saulnier, D.M., Riehle, K., Mistretta, T.A., Diaz, M.A., Mandal, D., Raza, S., Weidler, E.M., Qin, X., Coarfa, C., Milosavljevic, A., Petrosino, J.F., Highlander, S., Gibbs, R., Lynch, S.V., Shulman, R.J. and Versalovic, J., 2011. Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology 141: 1782-1791.
68. Scaldaferri, F., Gerardi, V., Lopetuso, L.R., Del Zompo, F., Mangiola, F., Boskoski, I., Bruno, G., Petito, V., Laterza, L., Cammarota, G., Gaetani, E., Sgambato, A. and Gasbarrini, A., 2013. Gut microbial flora, prebiotics, and probiotics in IBD: their current usage and utility. BioMed Research International 2013: 435268.
69. Scharl, M. and Rogler, G., 2012. Inflammatory bowel disease pathogenesis: what is new? Current Opinion in Gastroenterology 28: 301-309.
70. Schultz, M., Timmer, A., Herfarth, H.H., Sartor, R.B., Vanderhoof, J.A. and Rath, H.C., 2004. Lactobacillus GG in inducing and maintaining remission of Crohn's disease. BMC Gastroenterology 4: 5.
71. Shen, J., Zuo, Z.X. and Mao, A.P., 2014. Effect of Probiotics on Inducing Remission and Maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials. Inflammatory Bowel Diseases 20: 21-35.
72. Silk, D.B., Davis, A., Vulevic, J., Tzortzis, G. and Gibson, G.R., 2009. Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 29: 508-518.
73. Soo, I., Madsen, K.L., Tejpar, Q., Sydora, B.C., Sherbaniuk, R., Cinque, B., Di Marzio, L., Cifone, M.G., Desimone, C. and Fedorak, R.N., 2008. VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation. Canadian Journal of Gastroenterology 22: 237-242.
74. Sood, A., Midha, V., Makharia, G.K., Ahuja, V., Singal, D., Goswami, P. and Tandon, R.K., 2009. The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clinical Gastroenterology and Hepatology 7: 1202-1209, 1209 e1201.
75. Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N. and Whorwell, P., 2007. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56: 1770-1798.
76. Staudacher, H.M., Irving, P.M., Lomer, M.C. and Whelan, K., 2014. Mechanisms and efficacy of dietary FODMAP restriction in IBS. Nature Reviews Gastroenterology Hepatology 11: 256-266.
77. Steed, H., Macfarlane, G.T., Blackett, K.L., Bahrami, B., Reynolds, N., Walsh, S.V., Cummings, J.H. and Macfarlane, S., 2010. Clinical trial: the microbiological and immunological effects of synbiotic consumption-a randomized double-blind placebo-controlled study in active Crohn's disease. Alimentary Pharmacology and Therapeutics 32: 872-883.
78. Tabbers, M.M., Chmielewska, A., Roseboom, M.G., Boudet, C., Perrin, C., Szajewska, H. and Benninga, M.A., 2009. Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre randomised controlled trial (NTRTC: 1571). BMC Pediatrics 9: 22.
79. Tursi, A., Brandimarte, G., Giorgetti, G.M., Forti, G., Modeo, M.E. and Gigliobianco, A., 2004. Low-dose balsalazide plus a high-potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild-to-moderate ulcerative colitis. Medical Science Monitor 10: Pi126-131.
80. Tursi, A., Brandimarte, G., Papa, A., Giglio, A., Elisei, W., Giorgetti, G.M., Forti, G., Morini, S., Hassan, C., Pistoia, M.A., Modeo, M.E., Rodino, S., D'Amico, T., Sebkova, L., Sacca, N., Di Giulio, E., Luzza, F., Imeneo, M., Larussa, T., Di Rosa, S., Annese, V., Danese, S. and Gasbarrini, A., 2010. Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. American Journal of Gastroenterology 105: 2218-2227.
81. Van Gossum, A., Dewit, O., Louis, E., de Hertogh, G., Baert, F., Fontaine, F., DeVos, M., Enslen, M., Paintin, M. and Franchimont, D., 2007. Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflammatory Bowel Diseases 13: 135-142.
82. Welters, C.F., Heineman, E., Thunnissen, F.B., Van den Bogaard, A.E., Soeters, P.B. and Baeten, C.G., 2002. Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Diseases of the Colon and Rectum 45: 621-627.
83. Wong, A.P., Clark, A.L., Garnett, E.A., Acree, M., Cohen, S.A., Ferry, G.D. and Heyman, M.B., 2009. Use of complementary medicine in pediatric patients with inflammatory bowel disease: results from a multicenter survey. Journal of Pediatric Gastroenterology and Nutrition 48: 55-60.
84. Wu, X., Vallance, B.A., Boyer, L., Bergstrom, K.S., Walker, J., Madsen, K., O'Kusky, J.R., Buchan, A.M. and Jacobson, K., 2008. Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors. American Journal of Physiology-Gastrointestinal and Liver Physiology 294: G295-G306.
85. Zoumpopoulou, G., Foligne, B., Christodoulou, K., Grangette, C., Pot, B. and Tsakalidou, E., 2008. Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine models. International Journal of Food Microbiology 121: 18-26.