Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy

Free Radical Biology and Medicine

Volumn 92, Issue , 2016, Pages 90-99

  Qin, Tian ^a,b   Du, Ronghui ^a   Huang, Fengjie ^a,b   Yin, Shasha ^a   Yang, Jun ^a   Qin, Siyuan ^a   Cao, Wangsen ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HO 1; Inflammation; Macrophages; NF kB; Nrf2; Renoprotection; Sinomenine

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; SINOMENINE; TRANSCRIPTION FACTOR NRF2; HEME OXYGENASE 1; MORPHINAN DERIVATIVE; NFE2L2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE RAW 264.7; ENZYME ACTIVATION; HEK293 CELL LINE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INFLAMMATION; KIDNEY DISEASE; KIDNEY INJURY; MACROPHAGE; MOUSE; NONHUMAN; OBSTRUCTIVE NEPHROPATHY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENAL PROTECTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ACUTE KIDNEY INJURY; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECTS; GENETICS; INJURIES; KIDNEY; METABOLISM; PATHOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; DISEASE MODELS, ANIMAL; HEME OXYGENASE-1; HUMANS; INFLAMMATION; KIDNEY; MACROPHAGES; MICE; MORPHINANS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84956965095     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.01.011     Document Type: Article

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