MAPK signaling mediates sinomenine hydrochlorideinduced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: An in vitro and in vivo study

Cell Death and Disease

Volumn 5, Issue 7, 2014, Pages

  Li, X ^a   Wang, K ^a   Ren, Y ^a   Zhang, L ^a   Tang, X J ^a   Zhang, H M ^a   Zhao, C Q ^b   Liu, P J ^a   Zhang, J M ^a   He, J J ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; CHLORIDE; DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SINOMENINE; SINOMENINE HYDROCHLORIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MORPHINAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MEGADOSE; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MCF 7 CELL LINE; MDA MB 231 CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MORPHINANS; REACTIVE OXYGEN SPECIES;

EID: 84905493706     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.321     Document Type: Article

References (50)

1. Porter P. 'Westernizing' women's risks? Breast cancer in lower-income countries. New Engl J Med 2008; 358: 213-216.
2. Anderson BO, Jakesz R. Breast cancer issues in developing countries: an overview of the Breast Health Global Initiative. World J Surg 2008; 32: 2578-2585.
3. Benson JR, Jatoi I. The global breast cancer burden. Future Oncol 2012; 8: 697-702.
4. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30.
5. Redig AJ, McAllister SS. Breast cancer as a systemic disease: a view of metastasis. J Intern Med 2013; 274: 113-126.
6. O'Driscoll L, Clynes M. Biomarkers and multiple drug resistance in breast cancer. Curr Cancer Drug Targets 2006; 6: 365-384.
7. Brower V. Back to nature: extinction of medicinal plants threatens drug discovery. J Natl Cancer Inst 2008; 100: 838-839.
8. Li JWH, Vederas JC. Drug discovery and natural products: end of an era or an endless frontier? Science 2009; 325: 161-165.
9. Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med Okayama 1976; 30: 1-20.
10. Chen YW, Yang CY, Jin NS, Xie ZY, Fei L, Jia ZC et al. Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells. Int Immunopharmacol 2007; 7: 1102-1110.
11. Wang Y, Fang YF, Huang WH, Zhou X, Wang MH, Zhong B et al. Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. J Ethnopharmacol 2005; 98: 37-43.
12. Song SH, Shen XY, Tang Y, Wang ZX, Guo WY, Ding GS et al. Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: the role of heme oxygenase-1. Int Immunopharmacol 2010; 10: 679-684.
13. Wu WN, Wu PF, Chen XL, Zhang Z, Gu J, Yang YJ et al. Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels. Br J Pharmacol 2011; 164: 1445-1459.
14. Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflamm 2007; 19: 4-23.
15. Wang MH, Chang CK, Cheng JH, Wu HT, Li YX, Cheng JT. Activation of opioid mu-receptor by sinomenine in cell and mice. Neurosci Lett 2008; 443: 209-212.
16. Xu M, Liu L, Qi C, Deng B, Cai X. Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Planta Med 2008; 74: 1423-1429.
17. Li XJ, Yue PYK, Ha WY, Wong DYL, Tin MMY, Wang PX et al. Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma. Life Sci 2006; 79: 665-673.
18. Jiang TS, Zhou LP, Zhang WL, Qu D, Xu XM, Yang Y et al. Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro. Mol Med Rep 2010; 3: 51-56.
19. Lu XL, Zeng J, Chen YL, He PM, Wen MX, Ren MD et al. Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction. Int J Oncol 2013; 42: 229-238.
20. Whyte J, Bergin O, Bianchi A, McNally S, Martin F. Key signalling nodes in mammary gland development and cancer mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res 2009; 11: 5.
21. Milde-Langosch K, Bamberger AM, Rieck G, Grund D, Hemminger G, Muller V et al. Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer. Br J Cancer 2005; 92: 2206-2215.
22. Muscella A, Vetrugno C, Fanizzi FP, Manca C, De Pascali SA, Marsigliante S. A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells. Cell Death Dis 2013; 4: e796.
23. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281: 1312-1316.
24. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001; 276: 42462-42467.
25. Guo Z, Kumagai A, Wang SX, Dunphy WG. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000; 14: 2745-2756.
26. Melchionna R, Chen XB, Blasina A, McGowan CH. Threonine 68 is required for radiationinduced phosphorylation and activation of Cds1. Nat Cell Biol 2000; 2: 762-765.
27. Qi XF, Zheng L, Lee KJ, Kim DH, Kim CS, Cai DQ et al. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. Cell Death Dis 2013; 4: e518.
28. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-348.
29. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato JY, Livingston DM. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 1993; 73: 487-497.
30. Sherr CJ. The Pezcoller Lecture: cancer cell cycles revisited. Cancer Res 2000; 60: 3689-3695.
31. Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008; 14: 159-169.
32. Liu Y, Yeh N, Zhu XH, Leversha M, Cordon-Cardo C, Ghossein R et al. Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1). EMBO J 2007; 26: 4683-4693.
33. Fero ML. Hot papers - Cell biology - A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice by M.L. Fero, M. Rivkin, M. Tasch, P. Porter, C.E. Carow, E. Firpo, K. Polyak, L.H. Tsai, V. Broudy, R.M. Perlmutter, K. Kaushansky, J.M. Roberts - Comments. Scientist 1998; 12: 11-11.
34. Jin ZY, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005; 4: 139-163.
35. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281: 1322-1326.
36. Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000; 408: 433-439.
37. Vaux DL, Korsmeyer SJ. Cell death in development. Cell 1999; 96: 245-254.
38. Su B, Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol 1996; 8: 402-411.
39. Roovers K, Assoian RK. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 2000; 22: 818-826.
40. Herr I, Wilhelm D, Meyer E, Jeremias I, Angel P, Debatin KM. JNK/SAPK activity contributes to TRAIL-induced apoptosis. Cell Death Differ 1999; 6: 130-135.
41. Sanchez-Perez I, Murguia JR, Perona R. Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 1998; 16: 533-540.
42. Frasch SC, Nick JA, Fadok VA, Bratton DL, Worthen GS, Henson PM. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem 1998; 273: 8389-8397.
43. Park JS, Qiao L, Gilfor D, Yang MY, Hylemon PB, Benz C et al. A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21(Cip1/WAF1/mda6) protein levels in primary hepatocytes. Mol Biol Cell 2000; 11: 2915-2932.
44. Hui LJ, Bakiri L, Stepniak E, Wagner EF. p38 alpha - A suppressor of cell proliferation and tumorigenesis. Cell Cycle 2007; 6: 2429-2433.
45. Kim GY, Mercer SE, Ewton DZ, Yan ZF, Jin K, Friedman E. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 2002; 277: 29792-29802.
46. Yee AS, Paulson EK, McDevitt MA, Rieger-Christ K, Summerhayese I, Berasi SP et al. The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression. Gene 2004; 336: 1-13.
47. Casanovas O, Miro B, Estanyol JM, Itarte E, Agell N, Bachs O. Osmotic stress regulates the stability of cyclin D1 in a p38(SAPK2)-dependent manner. J Biol Chem 2000; 275: 35091-35097.
48. Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C et al. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J Biol Chem 1997; 272: 25238-25242.
49. Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ et al. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 1997; 139: 205-217.
50. Kranenburg O, vander Eb A, Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 1996; 15: 46-54.