A novel perspective and approach to intestinal octreotide absorption: Sinomenine-mediated reversible tight junction opening and its molecular mechanism

International Journal of Molecular Sciences

Volumn 14, Issue 6, 2013, Pages 12873-12892

  Li, Yuling ^a   Duan, Zhijun ^a   Tian, Yan ^a   Liu, Zhen ^a   Wang, Qiuming ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Intestinal absorption; Octreotide; Sinomenine; Tight junction

Indexed keywords

CLAUDIN 1; OCTREOTIDE; PROTEIN KINASE C; SINOMENINE; MESSENGER RNA; MORPHINAN DERIVATIVE; PROTEIN KINASE C ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ELECTRIC RESISTANCE; ENZYME ACTIVATION; FEASIBILITY STUDY; IMMUNOFLUORESCENCE TEST; INTESTINE ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; CACO 2 CELL LINE; CELL DEATH; CELL POLARITY; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMPEDANCE; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

RATTUS;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CLAUDIN-1; ELECTRIC IMPEDANCE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN VITRO TECHNIQUES; INTESTINAL ABSORPTION; MALE; MORPHINANS; OCTREOTIDE; PROTEIN KINASE C-ALPHA; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIGHT JUNCTIONS;

EID: 84879329108     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140612873     Document Type: Article

References (35)

1. Adelman, D.T.; Burgess, A.; Davies, P.R. Evaluation of long-acting somatostatin analog injection devices by nurses: A quantitative study. Med. Devices Auckl. 2012, 5, 103-109.
2. Le Quan, S.K.; Arnoux, J.B.; Mamoune, A.; Saint-Martin, C.; Bellanne-Chantelot, C.; Valayannopoulos, V.; Brassier, A.; Kayirangwa, H.; Barbier, V.; Broissand, C. et al. Successful treatment of congenital hyperinsulinism with long-acting release octreotide. Eur. J. Endocrinol. 2012, 166, 333-339.
3. Biron, E.; Chatterjee, J.; Ovadia, O.; Langenegger, D.; Brueggen, J.; Hoyer, D.; Schmid, H.A.; Jelinek, R.; Gilon, C.; Hoffman, A.; Kessler, H. Improving oral bioavailability of peptides by multiple N-methylation: Somatostatin analogues. Angew. Chem. Int. Ed. Engl. 2008, 47, 2595-2599.
4. Maggio, E.T.; Grasso, P. Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss webster mice. Regul Pept. 2011, 167, 233-238.
5. Garcia-Pagan, J.C.; Reverter, E.; Abraldes, J.G.; Bosch, J. Acute variceal bleeding. Semin. Respir. Crit. Care Med. 2012, 33, 46-54.
6. Rosenthal, R.; Heydt, M.S.; Amasheh, M.; Stein, C.; Fromm, M.; Amasheh, S. Analysis of absorption enhancers in epithelial cell models. Ann. N. Y. Acad. Sci. 2012, 1258, 86-92.
7. Lu, Z.; Chen, W.; Viljoen, A.; Hamman, J.H. Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds. Phytother. Res. 2010, 24, 211-218.
8. Chen, Z.M.; Liu, B.Q.; Boreham, J.; Wu, Y.P.; Chen, J.S.; Peto, R. Smoking and liver cancer in China: Case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths. Int. J. Cancer 2003, 107, 106-112.
9. Dorkoosh, F.A.; Verhoef, J.C.; Verheijden, J.H.; Rafiee-Tehrani, M.; Borchard, G.; Junginger, H.E. Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers. Pharm. Res. 2002, 19, 1532-1536.
10. Tuvia, S.; Atsmon, J.; Teichman, S.L.; Katz, S.; Salama, P.; Pelled, D.; Landau, I.; Karmeli, I.; Bidlingmaier, M.; Strasburger, C.J. et al. Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J. Clin. Endocrinol. Metab. 2012, 97, 2362-2369.
11. Dorkoosh, F.A.; Broekhuizen, C.A.; Borchard, G.; Rafiee-Tehrani, M.; Verhoef, J.C.; Junginger, H.E. Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers. J. Pharm. Sci. 2004, 93, 743-752.
12. Chan, K.; Liu, Z.Q.; Jiang, Z.H.; Zhou, H.; Wong, YF.; Xu, H.X.; Liu, L. The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. J. Ethnopharmacol. 2006, 103, 425-432.
13. Liu, Z.Q.; Jiang, Z.H.; Liu, L.; Hu, M. Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm. Res. 2006, 23, 2768-2780.
14. Liu, Z.Q.; Zhou, H.; Liu, L.; Jiang, Z.H.; Wong, Y.F.; Xie, Y.; Cai, X.; Xu, H.X.; Chan, K. Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats. J. Ethnopharmacol. 2005, 99, 61-67.
15. Zhao, X.X.; Peng, C.; Zhang, H.; Qin, L.P. Sinomenium acutum: A review of chemistry, pharmacology, pharmacokinetics, and clinical use. Pharm. Biol. 2012, 50, 1053-1061.
16. Cano-Cebrian, M.J.; Zornoza, T.; Granero, L.; Polache, A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery. Curr. Drug Deliv. 2005, 2, 9-22.
17. Liang, X.L.; Zhao, L.J.; Liao, Z.G.; Zhao, G.W.; Zhang, J.; Chao, Y.C.; Yang, M.; Yin, R.L. Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. J. Ethnopharmacol. 2012, 144, 677-682.
18. Konishi, T.; Satsu, H.; Hatsugai, Y.; Aizawa, K.; Inakuma, T.; Nagata, S.; Sakuda, S.H.; Nagasawa, H.; Shimizu, M. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br. J. Pharmacol. 2004, 143, 379-387.
19. Doi, N.; Tomita, M.; Hayashi, M. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers. Drug Metab. Pharmacokinet. 2011, 26, 162-170.
20. Aungst, B.J. Intestinal permeation enhancers. J. Pharm. Sci. 2000, 89, 429-442.
21. Yeh, T.H.; Hsu, L.W.; Tseng, M.T.; Lee, P.L.; Sonjae, K.; Ho, Y.C.; Sung, H.W. Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening. Biomaterials 2011, 32, 6164-6173.
22. Chiba, H.; Osanai, M.; Murata, M.; Kojima, T.; Sawada, N. Transmembrane proteins of tight junctions. Biochim. Biophys. Acta 2008, 1778, 588-600.
23. Furuse, M.; Hata, M.; Furuse, K.; Yoshida, Y.; Haratake, A.; Sugitani, Y.; Noda, T.; Kubo, A.; Tsukita, S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice. J. Cell Biol. 2002, 156, 1099-1111.
24. Gonzalez-Mariscal, L.; Tapia, R.; Chamorro, D. Crosstalk of tight junction components with signaling pathways. Biochim. Biophys. Acta 2008, 1778, 729-756.
25. Pinton, P.; Nougayrede, J.P.; Del, R.J.; Moreno, C.; Marin, D.E.; Ferrier, L.; Bracarense, A.P.; Kolf-Clauw, M.; Oswald, I.P. The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. Toxicol. Appl. Pharmacol. 2009, 237, 41-48.
26. Matter, K.; Balda, M.S. Signalling to and from tight junctions. Nat. Rev. Mol. Cell Biol. 2003, 4, 225-236.
27. Smith, J.M.; Dornish, M.; Wood, E.J. Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Biomaterials 2005, 26, 3269-3276.
28. Morreale, A.; Mallon, B.; Beale, G.; Watson, J.; Rumsby, M. Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. FEBS Lett. 1997, 417, 38-42.
29. Feng, X.; Becker, K.P.; Stribling, S.D.; Peters, K.G.; Hannun, Y.A. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J. Biol. Chem. 2000, 275, 17024-17034.
30. Barthe, L.; Woodley, J.; Houin, G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin. Pharmacol. 1999, 13, 154-168.
31. Eltink, C.; Lee, J.; Schaddelee, M.; Zhang, W.; Kerbusch, V.; Meijer, J.; van Marle, S.; Grunenberg, N.; Kowalski, D.; Drogendijk, T. et al. Single dose pharmacokinetics and absolute bioavailability of mirabegron, a beta(3)-adrenoceptor agonist for treatment of overactive bladder. Int. J. Clin. Pharmacol. Ther. 2012, 50, 838-850.
32. Madara, J.L.; Stafford, J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest. 1989, 83, 724-727.
33. Thanou, M.M.; Kotze, A.F.; Scharringhausen, T.; Luessen, H.L.; de Boer, A.G.; Verhoef, J.C.; Junginger, H.E. Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers. J. Control. Release 2000, 64, 15-25.
34. Chomczynski, P.; Sacchi, N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat. Protoc. 2006, 1, 581-585.
35. Kakinuma, S.; Tanaka, Y.; Chinzei, R.; Watanabe, M.; Shimizu-Saito, K.; Hara, Y.; Teramoto, K.; Arii, S.; Sato, C.; Takase, K. et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003, 21, 217-227.