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Volumn 46, Issue 2, 2016, Pages 281-290

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

Author keywords

Autoantibody; B cell; Systemic lupus erythematosus (SLE); Tfh cell

Indexed keywords

ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CELL ACTIVATION; DENDRITIC CELL; DISEASE COURSE; HELPER CELL; HUMAN; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; NOTE; PATHOGENESIS; PLASMACYTOID DENDRITIC CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T FOLLICULAR HELPER CELL; ANIMAL; ANTIGEN ANTIBODY COMPLEX; B LYMPHOCYTE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

EID: 84956925010     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545760     Document Type: Note
Times cited : (126)

References (123)
  • 1
    • 79960821762 scopus 로고
    • On the pathology of lupus erythematosus
    • 51.
    • Thin, G., On the pathology of lupus erythematosus. Med. Chir. Trans 1875. 58: 59-66 51.
    • (1875) Med. Chir. Trans , vol.58 , pp. 59-66
    • Thin, G.1
  • 2
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos, G. C., Systemic lupus erythematosus. N. Engl. J. Med. 365: 2110-2121.
    • N. Engl. J. Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 3
    • 84930040863 scopus 로고    scopus 로고
    • Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
    • Mohan, C. and Putterman, C., Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat. Rev. Nephrol. 11: 329-341.
    • Nat. Rev. Nephrol , vol.11 , pp. 329-341
    • Mohan, C.1    Putterman, C.2
  • 8
    • 84931424223 scopus 로고    scopus 로고
    • Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
    • Tipton, C. M., Fucile, C. F., Darce, J., Chida, A., Ichikawa, T., Gregoretti, I., Schieferl, S. et al., Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus. Nat. Immunol. 2015. 16: 755-765.
    • (2015) Nat. Immunol. , vol.16 , pp. 755-765
    • Tipton, C.M.1    Fucile, C.F.2    Darce, J.3    Chida, A.4    Ichikawa, T.5    Gregoretti, I.6    Schieferl, S.7
  • 9
    • 0035881627 scopus 로고    scopus 로고
    • Increased frequency of pre-germinal center b cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
    • Arce, E., Jackson, D. G., Gill, M. A., Bennett, L. B., Banchereau, J. and Pascual, V., Increased frequency of pre-germinal center b cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J. Immunol. 2001. 167: 2361-2369.
    • (2001) J. Immunol. , vol.167 , pp. 2361-2369
    • Arce, E.1    Jackson, D.G.2    Gill, M.A.3    Bennett, L.B.4    Banchereau, J.5    Pascual, V.6
  • 10
    • 0037991063 scopus 로고    scopus 로고
    • Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    • Jacobi, A. M., Odendahl, M., Reiter, K., Bruns, A., Burmester, G. R., Radbruch, A., Valet, G. et al., Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2003. 48: 1332-1342.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1332-1342
    • Jacobi, A.M.1    Odendahl, M.2    Reiter, K.3    Bruns, A.4    Burmester, G.R.5    Radbruch, A.6    Valet, G.7
  • 12
    • 82055177182 scopus 로고    scopus 로고
    • How T cells earn the follicular rite of passage
    • Vinuesa, C. G. and Cyster, J. G., How T cells earn the follicular rite of passage. Immunity 2011. 35: 671-680.
    • (2011) Immunity , vol.35 , pp. 671-680
    • Vinuesa, C.G.1    Cyster, J.G.2
  • 13
    • 84864303294 scopus 로고    scopus 로고
    • The origins, function, and regulation of T follicular helper cells
    • Ma, C. S., Deenick, E. K., Batten, M. and Tangye, S. G., The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 2012. 209: 1241-1253.
    • (2012) J. Exp. Med. , vol.209 , pp. 1241-1253
    • Ma, C.S.1    Deenick, E.K.2    Batten, M.3    Tangye, S.G.4
  • 14
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty, S., T follicular helper cell differentiation, function, and roles in disease. Immunity 2014. 41: 529-542.
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 15
    • 84922936572 scopus 로고    scopus 로고
    • Pathophysiology of T follicular helper cells in humans and mice
    • Ueno, H., Banchereau, J. and Vinuesa, C. G., Pathophysiology of T follicular helper cells in humans and mice. Nat. Immunol. 2015. 16: 142-152.
    • (2015) Nat. Immunol. , vol.16 , pp. 142-152
    • Ueno, H.1    Banchereau, J.2    Vinuesa, C.G.3
  • 17
    • 78649830454 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus in the genomic era
    • Deng, Y. and Tsao, B. P., Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat. Rev. Rheumatol. 2010. 6: 683-692.
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 683-692
    • Deng, Y.1    Tsao, B.P.2
  • 18
  • 19
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco, P., Palucka, A. K., Gill, M., Pascual, V. and Banchereau, J., Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001. 294: 1540-1543.
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 22
    • 84864874057 scopus 로고    scopus 로고
    • Type I IFN system in the development and manifestations of SLE
    • Elkon, K. B. and Wiedeman, A., Type I IFN system in the development and manifestations of SLE. Curr. Opin. Rheumatol. 2012. 24: 499-505.
    • (2012) Curr. Opin. Rheumatol. , vol.24 , pp. 499-505
    • Elkon, K.B.1    Wiedeman, A.2
  • 23
    • 84907212548 scopus 로고    scopus 로고
    • Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus
    • Sisirak, V., Ganguly, D., Lewis, K. L., Couillault, C., Tanaka, L., Bolland, S., D'Agati, V. et al., Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J. Exp. Med. 2014. 211: 1969-1976.
    • (2014) J. Exp. Med. , vol.211 , pp. 1969-1976
    • Sisirak, V.1    Ganguly, D.2    Lewis, K.L.3    Couillault, C.4    Tanaka, L.5    Bolland, S.6    D'Agati, V.7
  • 24
    • 0034665534 scopus 로고    scopus 로고
    • The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer
    • Bave, U., Alm, G. V. and Ronnblom, L., The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer. J. Immunol. 2000. 165: 3519-3526.
    • (2000) J. Immunol. , vol.165 , pp. 3519-3526
    • Bave, U.1    Alm, G.V.2    Ronnblom, L.3
  • 25
    • 0032586001 scopus 로고    scopus 로고
    • FCgammaRII (CD32)-dependent induction of interferon-alpha by serum from patients with lupus erythematosus
    • Batteux, F., Palmer, P., Daeron, M., Weill, B. and Lebon, P., FCgammaRII (CD32)-dependent induction of interferon-alpha by serum from patients with lupus erythematosus. Eur. Cytokine Netw. 1999. 10: 509-514.
    • (1999) Eur. Cytokine Netw. , vol.10 , pp. 509-514
    • Batteux, F.1    Palmer, P.2    Daeron, M.3    Weill, B.4    Lebon, P.5
  • 26
    • 0038639795 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and the type I interferon system
    • Ronnblom, L. and Alm, G. V., Systemic lupus erythematosus and the type I interferon system. Arthritis Res. Ther. 2003. 5: 68-75.
    • (2003) Arthritis Res. Ther. , vol.5 , pp. 68-75
    • Ronnblom, L.1    Alm, G.V.2
  • 27
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat, F. J. and Coffman, R. L., Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol. Rev. 2008. 223: 271-283.
    • (2008) Immunol. Rev. , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 28
    • 84935747373 scopus 로고    scopus 로고
    • Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE
    • Saito, K., Kukita, K., Kutomi, G., Okuya, K., Asanuma, H., Tabeya, T., Naishiro, Y. et al., Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur. J. Immunol. 2015. 45: 2028-2041.
    • (2015) Eur. J. Immunol. , vol.45 , pp. 2028-2041
    • Saito, K.1    Kukita, K.2    Kutomi, G.3    Okuya, K.4    Asanuma, H.5    Tabeya, T.6    Naishiro, Y.7
  • 29
    • 79952476762 scopus 로고    scopus 로고
    • Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus
    • ra20.
    • Garcia-Romo, G. S., Caielli, S., Vega, B., Connolly, J., Allantaz, F., Xu, Z., Punaro, M. et al., Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci. Transl. Med. 3: 73ra20.
    • Sci. Transl. Med , vol.3 , pp. 73
    • Garcia-Romo, G.S.1    Caielli, S.2    Vega, B.3    Connolly, J.4    Allantaz, F.5    Xu, Z.6    Punaro, M.7
  • 30
    • 77956454663 scopus 로고    scopus 로고
    • Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus
    • Duffau, P., Seneschal, J., Nicco, C., Richez, C., Lazaro, E., Douchet, I., Bordes, C. et al., Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci. Transl. Med. 2: 47ra63.
    • Sci. Transl. Med , vol.2 , pp. 47ra63
    • Duffau, P.1    Seneschal, J.2    Nicco, C.3    Richez, C.4    Lazaro, E.5    Douchet, I.6    Bordes, C.7
  • 31
    • 79955537167 scopus 로고    scopus 로고
    • IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1
    • Hagberg, N., Berggren, O., Leonard, D., Weber, G., Bryceson, Y. T., Alm, G. V., Eloranta, M. L. et al., IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1. J. Immunol. 186: 5085-5094.
    • J. Immunol , vol.186 , pp. 5085-5094
    • Hagberg, N.1    Berggren, O.2    Leonard, D.3    Weber, G.4    Bryceson, Y.T.5    Alm, G.V.6    Eloranta, M.L.7
  • 32
    • 33750348046 scopus 로고    scopus 로고
    • Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus
    • Ding, D., Mehta, H., McCune, W. J. and Kaplan, M. J., Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. J. Immunol. 2006. 177: 5878-5889.
    • (2006) J. Immunol. , vol.177 , pp. 5878-5889
    • Ding, D.1    Mehta, H.2    McCune, W.J.3    Kaplan, M.J.4
  • 33
    • 84858080571 scopus 로고    scopus 로고
    • Phenotype and function of dendritic cells of patients with systemic lupus erythematosus
    • Crispin, J. C., Vargas-Rojas, M. I., Monsivais-Urenda, A. and Alcocer-Varela, J., Phenotype and function of dendritic cells of patients with systemic lupus erythematosus. Clin. Immunol. 2012. 143: 45-50.
    • (2012) Clin. Immunol. , vol.143 , pp. 45-50
    • Crispin, J.C.1    Vargas-Rojas, M.I.2    Monsivais-Urenda, A.3    Alcocer-Varela, J.4
  • 34
    • 33749622448 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus
    • Decker, P., Kotter, I., Klein, R., Berner, B. and Rammensee, H. G., Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2006. 45: 1087-1095.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1087-1095
    • Decker, P.1    Kotter, I.2    Klein, R.3    Berner, B.4    Rammensee, H.G.5
  • 36
  • 37
    • 0041429619 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    • Jego, G., Palucka, A. K., Blanck, J. P., Chalouni, C., Pascual, V. and Banchereau, J., Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 2003. 19: 225-234.
    • (2003) Immunity , vol.19 , pp. 225-234
    • Jego, G.1    Palucka, A.K.2    Blanck, J.P.3    Chalouni, C.4    Pascual, V.5    Banchereau, J.6
  • 39
    • 84864296905 scopus 로고    scopus 로고
    • Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation
    • Joo, H., Coquery, C., Xue, Y., Gayet, I., Dillon, S. R., Punaro, M., Zurawski, G. et al., Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation. J. Exp. Med. 2012. 209: 1335-1348.
    • (2012) J. Exp. Med. , vol.209 , pp. 1335-1348
    • Joo, H.1    Coquery, C.2    Xue, Y.3    Gayet, I.4    Dillon, S.R.5    Punaro, M.6    Zurawski, G.7
  • 40
    • 80051978792 scopus 로고    scopus 로고
    • Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers
    • Bentebibel, S. E., Schmitt, N., Banchereau, J. and Ueno, H., Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc. Natl. Acad. Sci. USA 2011. 108: E488-E497.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. E488-E497
    • Bentebibel, S.E.1    Schmitt, N.2    Banchereau, J.3    Ueno, H.4
  • 42
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y. H. et al., Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008. 29: 138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6    Wang, Y.H.7
  • 43
    • 33749151018 scopus 로고    scopus 로고
    • ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells
    • Bossaller, L., Burger, J., Draeger, R., Grimbacher, B., Knoth, R., Plebani, A., Durandy, A. et al., ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J. Immunol. 2006. 177: 4927-4932.
    • (2006) J. Immunol. , vol.177 , pp. 4927-4932
    • Bossaller, L.1    Burger, J.2    Draeger, R.3    Grimbacher, B.4    Knoth, R.5    Plebani, A.6    Durandy, A.7
  • 44
    • 79952114884 scopus 로고    scopus 로고
    • B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis
    • Hamel, K. M., Cao, Y., Wang, Y., Rodeghero, R., Kobezda, T., Chen, L. and Finnegan, A., B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis. Eur. J. Immunol. 2010. 40: 3117-3127.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3117-3127
    • Hamel, K.M.1    Cao, Y.2    Wang, Y.3    Rodeghero, R.4    Kobezda, T.5    Chen, L.6    Finnegan, A.7
  • 45
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • Good-Jacobson, K. L., Szumilas, C. G., Chen, L., Sharpe, A. H., Tomayko, M. M. and Shlomchik, M. J., PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat. Immunol. 2010. 11: 535-542.
    • (2010) Nat. Immunol. , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1    Szumilas, C.G.2    Chen, L.3    Sharpe, A.H.4    Tomayko, M.M.5    Shlomchik, M.J.6
  • 46
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    • Bryant, V. L., Ma, C. S., Avery, D. T., Li, Y., Good, K. L., Corcoran, L. M., de Waal Malefyt, R. et al., Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 2007. 179: 8180-8190.
    • (2007) J. Immunol. , vol.179 , pp. 8180-8190
    • Bryant, V.L.1    Ma, C.S.2    Avery, D.T.3    Li, Y.4    Good, K.L.5    Corcoran, L.M.6    de Waal Malefyt, R.7
  • 47
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S. and Mackay, C. R., T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 2004. 173: 68-78.
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 48
    • 80051978792 scopus 로고    scopus 로고
    • Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers
    • Bentebibel, S.-E., Schmitt, N., Banchereau, J. and Ueno, H., Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc. Natl. Acad. Sci. USA 2011. 10.1073/pnas.1100898108.
    • (2011) Proc. Natl. Acad. Sci. USA
    • Bentebibel, S.-E.1    Schmitt, N.2    Banchereau, J.3    Ueno, H.4
  • 49
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: basic biology and implications for cancer and autoimmunity
    • Spolski, R. and Leonard, W. J., Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 2008. 26: 57-79.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 50
  • 51
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos, D., Coquet, J. M., Zhang, Y., Light, A., D'Costa, K., Kallies, A., Corcoran, L. M. et al., IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med. 2010. 207: 365-378.
    • (2010) J. Exp. Med. , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3    Light, A.4    D'Costa, K.5    Kallies, A.6    Corcoran, L.M.7
  • 53
    • 79960342424 scopus 로고    scopus 로고
    • B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
    • Lee, S. K., Rigby, R. J., Zotos, D., Tsai, L. M., Kawamoto, S., Marshall, J. L., Ramiscal, R. R. et al., B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J. Exp. Med. 2011. 208: 1377-1388.
    • (2011) J. Exp. Med. , vol.208 , pp. 1377-1388
    • Lee, S.K.1    Rigby, R.J.2    Zotos, D.3    Tsai, L.M.4    Kawamoto, S.5    Marshall, J.L.6    Ramiscal, R.R.7
  • 55
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa, C. G., Cook, M. C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K. M., Yu, D. et al., A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005. 435: 452-458.
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6    Yu, D.7
  • 56
    • 84876781274 scopus 로고    scopus 로고
    • Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation
    • Vogel, K. U., Edelmann, S. L., Jeltsch, K. M., Bertossi, A., Heger, K., Heinz, G. A., Zoller, J. et al., Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 2013. 38: 655-668.
    • (2013) Immunity , vol.38 , pp. 655-668
    • Vogel, K.U.1    Edelmann, S.L.2    Jeltsch, K.M.3    Bertossi, A.4    Heger, K.5    Heinz, G.A.6    Zoller, J.7
  • 57
    • 84876775237 scopus 로고    scopus 로고
    • Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation
    • Pratama, A., Ramiscal, R. R., Silva, D. G., Das, S. K., Athanasopoulos, V., Fitch, J., Botelho, N. K. et al., Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity 2013. 38: 669-680.
    • (2013) Immunity , vol.38 , pp. 669-680
    • Pratama, A.1    Ramiscal, R.R.2    Silva, D.G.3    Das, S.K.4    Athanasopoulos, V.5    Fitch, J.6    Botelho, N.K.7
  • 58
    • 36048946330 scopus 로고    scopus 로고
    • Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    • Yu, D., Tan, A. H., Hu, X., Athanasopoulos, V., Simpson, N., Silva, D. G., Hutloff, A. et al., Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 2007. 450: 299-303.
    • (2007) Nature , vol.450 , pp. 299-303
    • Yu, D.1    Tan, A.H.2    Hu, X.3    Athanasopoulos, V.4    Simpson, N.5    Silva, D.G.6    Hutloff, A.7
  • 59
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed, A. U., Rahn, H. P., Sallusto, F., Lipp, M. and Muller, G., Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 2006. 36: 1892-1903.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 61
    • 58149279490 scopus 로고    scopus 로고
    • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    • Odegard, J. M., Marks, B. R., DiPlacido, L. D., Poholek, A. C., Kono, D. H., Dong, C., Flavell, R. A. et al., ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J. Exp. Med. 2008. 205: 2873-2886.
    • (2008) J. Exp. Med. , vol.205 , pp. 2873-2886
    • Odegard, J.M.1    Marks, B.R.2    DiPlacido, L.D.3    Poholek, A.C.4    Kono, D.H.5    Dong, C.6    Flavell, R.A.7
  • 62
    • 84899112642 scopus 로고    scopus 로고
    • Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue
    • Liarski, V. M., Kaverina, N., Chang, A., Brandt, D., Yanez, D., Talasnik, L., Carlesso, G. et al., Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue. Sci. Transl. Med. 2014. 6: 230ra246.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 230ra246
    • Liarski, V.M.1    Kaverina, N.2    Chang, A.3    Brandt, D.4    Yanez, D.5    Talasnik, L.6    Carlesso, G.7
  • 63
    • 84922551023 scopus 로고    scopus 로고
    • Phenotype and functions of memory Tfh cells in human blood
    • Schmitt, N., Bentebibel, S. E. and Ueno, H., Phenotype and functions of memory Tfh cells in human blood. Trends Immunol. 2014. 35: 436-442.
    • (2014) Trends Immunol. , vol.35 , pp. 436-442
    • Schmitt, N.1    Bentebibel, S.E.2    Ueno, H.3
  • 64
    • 78751690647 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita, R., Schmitt, N., Bentebibel, S. E., Ranganathan, R., Bourdery, L., Zurawski, G., Foucat, E. et al., Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011. 34: 108-121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6    Foucat, E.7
  • 65
    • 84884367704 scopus 로고    scopus 로고
    • Circulating TFH subset distribution is strongly affected in lupus patients with an active disease
    • Le Coz, C., Joublin, A., Pasquali, J. L., Korganow, A. S., Dumortier, H. and Monneaux, F., Circulating TFH subset distribution is strongly affected in lupus patients with an active disease. PLoS One 2013. 8: e75319.
    • (2013) PLoS One , vol.8 , pp. e75319
    • Le Coz, C.1    Joublin, A.2    Pasquali, J.L.3    Korganow, A.S.4    Dumortier, H.5    Monneaux, F.6
  • 66
    • 84925762443 scopus 로고    scopus 로고
    • Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity
    • Choi, J. Y., Ho, J. H., Pasoto, S. G., Bunin, V., Kim, S. T., Carrasco, S., Borba, E. F. et al., Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity. Arthritis Rheumatol. 2015. 67: 988-999.
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 988-999
    • Choi, J.Y.1    Ho, J.H.2    Pasoto, S.G.3    Bunin, V.4    Kim, S.T.5    Carrasco, S.6    Borba, E.F.7
  • 67
    • 84861670170 scopus 로고    scopus 로고
    • Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjogren's syndrome
    • Li, X. Y., Wu, Z. B., Ding, J., Zheng, Z. H., Li, X. Y., Chen, L. N. and Zhu, P., Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjogren's syndrome. Biochem. Biophys. Res. Commun. 2012. 422: 238-244.
    • (2012) Biochem. Biophys. Res. Commun. , vol.422 , pp. 238-244
    • Li, X.Y.1    Wu, Z.B.2    Ding, J.3    Zheng, Z.H.4    Li, X.Y.5    Chen, L.N.6    Zhu, P.7
  • 69
    • 84874566824 scopus 로고    scopus 로고
    • Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression
    • Romme Christensen, J., Bornsen, L., Ratzer, R., Piehl, F., Khademi, M., Olsson, T., Sorensen, P. S. et al., Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression. PLoS One 2013. 8: e57820.
    • (2013) PLoS One , vol.8 , pp. e57820
    • Romme Christensen, J.1    Bornsen, L.2    Ratzer, R.3    Piehl, F.4    Khademi, M.5    Olsson, T.6    Sorensen, P.S.7
  • 70
    • 84885741984 scopus 로고    scopus 로고
    • Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    • He, J., Tsai, L. M., Leong, Y. A., Hu, X., Ma, C. S., Chevalier, N., Sun, X. et al., Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity 2013. 39: 770-781.
    • (2013) Immunity , vol.39 , pp. 770-781
    • He, J.1    Tsai, L.M.2    Leong, Y.A.3    Hu, X.4    Ma, C.S.5    Chevalier, N.6    Sun, X.7
  • 71
    • 84885743368 scopus 로고    scopus 로고
    • Human circulating PD-1(+)CXCR3(-)CXCR5(+) memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • Locci, M., Havenar-Daughton, C., Landais, E., Wu, J., Kroenke, M. A., Arlehamn, C. L., Su, L. F. et al., Human circulating PD-1(+)CXCR3(-)CXCR5(+) memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity 2013. 39: 758-769.
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1    Havenar-Daughton, C.2    Landais, E.3    Wu, J.4    Kroenke, M.A.5    Arlehamn, C.L.6    Su, L.F.7
  • 72
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson, N., Gatenby, P. A., Wilson, A., Malik, S., Fulcher, D. A., Tangye, S. G., Manku, H. et al., Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 2010. 62: 234-244.
    • (2010) Arthritis Rheum. , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6    Manku, H.7
  • 73
    • 84906306956 scopus 로고    scopus 로고
    • The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
    • Schmitt, N., Liu, Y., Bentebibel, S. E., Munagala, I., Bourdery, L., Venuprasad, K., Banchereau, J. et al., The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat. Immunol. 2014. 15: 856-865.
    • (2014) Nat. Immunol. , vol.15 , pp. 856-865
    • Schmitt, N.1    Liu, Y.2    Bentebibel, S.E.3    Munagala, I.4    Bourdery, L.5    Venuprasad, K.6    Banchereau, J.7
  • 75
    • 84859711557 scopus 로고    scopus 로고
    • Functional STAT3 deficiency compromises the generation of human T follicular helper cells
    • Ma, C. S., Avery, D. T., Chan, A., Batten, M., Bustamante, J., Boisson-Dupuis, S., Arkwright, P. D. et al., Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood 2012. 119: 3997-4008.
    • (2012) Blood , vol.119 , pp. 3997-4008
    • Ma, C.S.1    Avery, D.T.2    Chan, A.3    Batten, M.4    Bustamante, J.5    Boisson-Dupuis, S.6    Arkwright, P.D.7
  • 78
    • 45249097325 scopus 로고    scopus 로고
    • Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    • Wong, C. K., Lit, L. C., Tam, L. S., Li, E. K., Wong, P. T. and Lam, C. W., Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol. 2008. 127: 385-393.
    • (2008) Clin. Immunol. , vol.127 , pp. 385-393
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Wong, P.T.5    Lam, C.W.6
  • 80
    • 84873720955 scopus 로고    scopus 로고
    • Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important pro-inflammatory cell type in lupus erythematosus
    • Hansel, A., Gunther, C., Baran, W., Bidier, M., Lorenz, H. M., Schmitz, M., Bachmann, M. et al., Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important pro-inflammatory cell type in lupus erythematosus. J. Autoimmun. 2013. 40: 1-8.
    • (2013) J. Autoimmun. , vol.40 , pp. 1-8
    • Hansel, A.1    Gunther, C.2    Baran, W.3    Bidier, M.4    Lorenz, H.M.5    Schmitz, M.6    Bachmann, M.7
  • 81
    • 53349146043 scopus 로고    scopus 로고
    • Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis
    • Tucci, M., Lombardi, L., Richards, H. B., Dammacco, F. and Silvestris, F., Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis. Clin. Exp. Immunol 2008. 154: 247-254.
    • (2008) Clin. Exp. Immunol , vol.154 , pp. 247-254
    • Tucci, M.1    Lombardi, L.2    Richards, H.B.3    Dammacco, F.4    Silvestris, F.5
  • 82
    • 84860476524 scopus 로고    scopus 로고
    • Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus
    • Smith, S., Gabhann, J. N., Higgs, R., Stacey, K., Wahren-Herlenius, M., Espinosa, A., Totaro, M. G. et al., Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus. Arthritis Rheum. 2012. 64: 1601-1609.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1601-1609
    • Smith, S.1    Gabhann, J.N.2    Higgs, R.3    Stacey, K.4    Wahren-Herlenius, M.5    Espinosa, A.6    Totaro, M.G.7
  • 83
    • 18644364701 scopus 로고    scopus 로고
    • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    • Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E. E., Trinchieri, G. et al., A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J. Exp. Med. 2005. 201: 1435-1446.
    • (2005) J. Exp. Med. , vol.201 , pp. 1435-1446
    • Gautier, G.1    Humbert, M.2    Deauvieau, F.3    Scuiller, M.4    Hiscott, J.5    Bates, E.E.6    Trinchieri, G.7
  • 84
    • 40749089639 scopus 로고    scopus 로고
    • Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage
    • Saxena, V., Lienesch, D. W., Zhou, M., Bommireddy, R., Azhar, M., Doetschman, T. and Singh, R. R., Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. J. Immunol. 2008. 180: 1903-1912.
    • (2008) J. Immunol. , vol.180 , pp. 1903-1912
    • Saxena, V.1    Lienesch, D.W.2    Zhou, M.3    Bommireddy, R.4    Azhar, M.5    Doetschman, T.6    Singh, R.R.7
  • 85
    • 0025102712 scopus 로고
    • Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix
    • Okuda, S., Languino, L. R., Ruoslahti, E. and Border, W. A., Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J. Clin. Invest. 1990. 86: 453-462.
    • (1990) J. Clin. Invest. , vol.86 , pp. 453-462
    • Okuda, S.1    Languino, L.R.2    Ruoslahti, E.3    Border, W.A.4
  • 86
    • 23444434705 scopus 로고    scopus 로고
    • The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    • Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J. et al., The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J. Immunol. 2005. 175: 2340-2348.
    • (2005) J. Immunol. , vol.175 , pp. 2340-2348
    • Akiba, H.1    Takeda, K.2    Kojima, Y.3    Usui, Y.4    Harada, N.5    Yamazaki, T.6    Ma, J.7
  • 87
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi, Y. S., Kageyama, R., Eto, D., Escobar, T. C., Johnston, R. J., Monticelli, L., Lao, C. and Crotty, S., ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011. 34: 932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6    Lao, C.7    Crotty, S.8
  • 88
    • 84876793426 scopus 로고    scopus 로고
    • Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
    • Xu, H., Li, X., Liu, D., Li, J., Zhang, X., Chen, X., Hou, S. et al., Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 2013. 496: 523-527.
    • (2013) Nature , vol.496 , pp. 523-527
    • Xu, H.1    Li, X.2    Liu, D.3    Li, J.4    Zhang, X.5    Chen, X.6    Hou, S.7
  • 89
    • 84924993521 scopus 로고    scopus 로고
    • Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
    • Teichmann, L. L., Cullen, J. L., Kashgarian, M., Dong, C., Craft, J. and Shlomchik, M. J., Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity 2015. 42: 552-565.
    • (2015) Immunity , vol.42 , pp. 552-565
    • Teichmann, L.L.1    Cullen, J.L.2    Kashgarian, M.3    Dong, C.4    Craft, J.5    Shlomchik, M.J.6
  • 90
    • 0041331737 scopus 로고    scopus 로고
    • Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis
    • Iwai, H., Abe, M., Hirose, S., Tsushima, F., Tezuka, K., Akiba, H., Yagita, H. et al., Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J. Immunol. 2003. 171: 2848-2854.
    • (2003) J. Immunol. , vol.171 , pp. 2848-2854
    • Iwai, H.1    Abe, M.2    Hirose, S.3    Tsushima, F.4    Tezuka, K.5    Akiba, H.6    Yagita, H.7
  • 91
  • 92
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • Croft, M., Control of immunity by the TNFR-related molecule OX40 (CD134). Ann. Rev. Immunol. 2010. 28: 57-78.
    • (2010) Ann. Rev. Immunol. , vol.28 , pp. 57-78
    • Croft, M.1
  • 94
    • 84893759837 scopus 로고    scopus 로고
    • The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus
    • Lan, Y., Luo, B., Wang, J. L., Jiang, Y. W. and Wei, Y. S., The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus. Gene 2014. 538: 94-98.
    • (2014) Gene , vol.538 , pp. 94-98
    • Lan, Y.1    Luo, B.2    Wang, J.L.3    Jiang, Y.W.4    Wei, Y.S.5
  • 96
    • 84949097483 scopus 로고    scopus 로고
    • Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
    • Bentham, J., Morris, D. L., Cunninghame Graham, D. S., Pinder, C. L., Tombleson, P., Behrens, T. W., Martin, J. et al., Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 2015. 47: 1457-1464.
    • (2015) Nat. Genet. , vol.47 , pp. 1457-1464
    • Bentham, J.1    Morris, D.L.2    Cunninghame Graham, D.S.3    Pinder, C.L.4    Tombleson, P.5    Behrens, T.W.6    Martin, J.7
  • 98
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson, S., Nordmark, G., Goring, H. H., Lindroos, K., Wiman, A. C., Sturfelt, G., Jonsen, A. et al., Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am. J. Hum. Genet. 2005. 76: 528-537.
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 528-537
    • Sigurdsson, S.1    Nordmark, G.2    Goring, H.H.3    Lindroos, K.4    Wiman, A.C.5    Sturfelt, G.6    Jonsen, A.7
  • 100
    • 33646368404 scopus 로고    scopus 로고
    • A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
    • Graham, R. R., Kozyrev, S. V., Baechler, E. C., Reddy, M. V., Plenge, R. M., Bauer, J. W., Ortmann, W. A. et al., A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat. Genet. 2006. 38: 550-555.
    • (2006) Nat. Genet. , vol.38 , pp. 550-555
    • Graham, R.R.1    Kozyrev, S.V.2    Baechler, E.C.3    Reddy, M.V.4    Plenge, R.M.5    Bauer, J.W.6    Ortmann, W.A.7
  • 101
    • 84859491100 scopus 로고    scopus 로고
    • Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study
    • Lessard, C. J., Adrianto, I., Ice, J. A., Wiley, G. B., Kelly, J. A., Glenn, S. B., Adler, A. J. et al., Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am. J. Hum. Genet. 2012. 90: 648-660.
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 648-660
    • Lessard, C.J.1    Adrianto, I.2    Ice, J.A.3    Wiley, G.B.4    Kelly, J.A.5    Glenn, S.B.6    Adler, A.J.7
  • 104
    • 84894280989 scopus 로고    scopus 로고
    • The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation
    • Yoshida, Y., Yoshimi, R., Yoshii, H., Kim, D., Dey, A., Xiong, H., Munasinghe, J. et al., The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation. Immunity 2014. 40: 187-198.
    • (2014) Immunity , vol.40 , pp. 187-198
    • Yoshida, Y.1    Yoshimi, R.2    Yoshii, H.3    Kim, D.4    Dey, A.5    Xiong, H.6    Munasinghe, J.7
  • 105
    • 84902212735 scopus 로고    scopus 로고
    • IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes
    • Rodriguez-Pla, A., Patel, P., Maecker, H. T., Rossello-Urgell, J., Baldwin, N., Bennett, L., Cantrell, V. et al., IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes. J. Immunol. 2014. 192: 5586-5598.
    • (2014) J. Immunol. , vol.192 , pp. 5586-5598
    • Rodriguez-Pla, A.1    Patel, P.2    Maecker, H.T.3    Rossello-Urgell, J.4    Baldwin, N.5    Bennett, L.6    Cantrell, V.7
  • 106
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    • Navarra, S. V., Guzman, R. M., Gallacher, A. E., Hall, S., Levy, R. A., Jimenez, R. E., Li, E. K. et al., Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet. 2011. 377: 721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3    Hall, S.4    Levy, R.A.5    Jimenez, R.E.6    Li, E.K.7
  • 108
    • 74849131972 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    • Merrill, J. T., Neuwelt, C. M., Wallace, D. J., Shanahan, J. C., Latinis, K. M., Oates, J. C., Utset, T. O. et al., Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum. 2010. 62: 222-233.
    • (2010) Arthritis Rheum , vol.62 , pp. 222-233
    • Merrill, J.T.1    Neuwelt, C.M.2    Wallace, D.J.3    Shanahan, J.C.4    Latinis, K.M.5    Oates, J.C.6    Utset, T.O.7
  • 109
    • 84866184129 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study
    • Rovin, B. H., Furie, R., Latinis, K., Looney, R. J., Fervenza, F. C., Sanchez-Guerrero, J., Maciuca, R. et al., Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum. 64: 1215-1226.
    • Arthritis Rheum , vol.64 , pp. 1215-1226
    • Rovin, B.H.1    Furie, R.2    Latinis, K.3    Looney, R.J.4    Fervenza, F.C.5    Sanchez-Guerrero, J.6    Maciuca, R.7
  • 111
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos, P. I. and Boumpas, D. T., Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004. 13: 391-397.
    • (2004) Lupus , vol.13 , pp. 391-397
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 112
    • 0032030667 scopus 로고    scopus 로고
    • Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function
    • Kalled, S. L., Cutler, A. H., Datta, S. K. and Thomas, D. W., Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function. J. Immunol. 1998. 160: 2158-2165.
    • (1998) J. Immunol. , vol.160 , pp. 2158-2165
    • Kalled, S.L.1    Cutler, A.H.2    Datta, S.K.3    Thomas, D.W.4
  • 113
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas, D. T., Furie, R., Manzi, S., Illei, G. G., Wallace, D. J., Balow, J. E. and Vaishnaw, A., A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum. 2003. 48: 719-727.
    • (2003) Arthritis Rheum. , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6    Vaishnaw, A.7
  • 114
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber, D., Brown, T. P., Liang, S., Young, D. A., Collins, M. and Dunussi-Joannopoulos, K., IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J. Immunol. 2007. 178: 3822-3830.
    • (2007) J. Immunol. , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6
  • 115
    • 34247257447 scopus 로고    scopus 로고
    • Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    • Young, D. A., Hegen, M., Ma, H. L., Whitters, M. J., Albert, L. M., Lowe, L., Senices, M. et al., Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 2007. 56: 1152-1163.
    • (2007) Arthritis Rheum. , vol.56 , pp. 1152-1163
    • Young, D.A.1    Hegen, M.2    Ma, H.L.3    Whitters, M.J.4    Albert, L.M.5    Lowe, L.6    Senices, M.7
  • 117
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • Klatzmann, D. and Abbas, A. K., The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat. Rev. Immunol. 2015. 15: 283-294.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2
  • 118
    • 84925622462 scopus 로고    scopus 로고
    • T cells as a therapeutic target in SLE
    • Comte, D., Karampetsou, M. P. and Tsokos, G. C., T cells as a therapeutic target in SLE. Lupus 2015. 24: 351-363.
    • (2015) Lupus , vol.24 , pp. 351-363
    • Comte, D.1    Karampetsou, M.P.2    Tsokos, G.C.3
  • 119
    • 84940880014 scopus 로고    scopus 로고
    • Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
    • von Spee-Mayer, C., Siegert, E., Abdirama, D., Rose, A., Klaus, A., Alexander, T., Enghard, P. et al., Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 2015. doi: 10.1136/annrheumdis-2015-207776.
    • (2015) Ann. Rheum. Dis.
    • von Spee-Mayer, C.1    Siegert, E.2    Abdirama, D.3    Rose, A.4    Klaus, A.5    Alexander, T.6    Enghard, P.7
  • 120
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato, A., Leon, B., Graf, B. A., Moquin, A., Adams, P. S., Lund, F. E. and Randall, T. D., Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 2012. 36: 847-856.
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1    Leon, B.2    Graf, B.A.3    Moquin, A.4    Adams, P.S.5    Lund, F.E.6    Randall, T.D.7
  • 121
    • 84863116170 scopus 로고    scopus 로고
    • STAT5 is a potent negative regulator of TFH cell differentiation
    • Johnston, R. J., Choi, Y. S., Diamond, J. A., Yang, J. A. and Crotty, S., STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 2012. 209: 243-250.
    • (2012) J. Exp. Med. , vol.209 , pp. 243-250
    • Johnston, R.J.1    Choi, Y.S.2    Diamond, J.A.3    Yang, J.A.4    Crotty, S.5
  • 122
    • 84859487740 scopus 로고    scopus 로고
    • STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
    • Nurieva, R. I., Podd, A., Chen, Y., Alekseev, A. M., Yu, M., Qi, X., Huang, H. et al., STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J. Biol. Chem. 2012. 287: 11234-11239.
    • (2012) J. Biol. Chem. , vol.287 , pp. 11234-11239
    • Nurieva, R.I.1    Podd, A.2    Chen, Y.3    Alekseev, A.M.4    Yu, M.5    Qi, X.6    Huang, H.7
  • 123
    • 84937635672 scopus 로고    scopus 로고
    • T follicular regulatory cells in the regulation of B cell responses
    • Sage, P. T. and Sharpe, A. H., T follicular regulatory cells in the regulation of B cell responses. Trends Immunol. 2015. 36: 410-418.
    • (2015) Trends Immunol. , vol.36 , pp. 410-418
    • Sage, P.T.1    Sharpe, A.H.2


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