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Volumn 40, Issue 2, 2014, Pages 187-198

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTEGRIN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 27; TRANSFORMING GROWTH FACTOR BETA;

EID: 84894280989     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.11.022     Document Type: Article
Times cited : (118)

References (49)
  • 1
    • 78649819162 scopus 로고    scopus 로고
    • αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
    • Acharya M., Mukhopadhyay S., Païdassi H., Jamil T., Chow C., Kissler S., Stuart L.M., Hynes R.O., Lacy-Hulbert A. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J.Clin. Invest. 2010, 120:4445-4452.
    • (2010) J.Clin. Invest. , vol.120 , pp. 4445-4452
    • Acharya, M.1    Mukhopadhyay, S.2    Païdassi, H.3    Jamil, T.4    Chow, C.5    Kissler, S.6    Stuart, L.M.7    Hynes, R.O.8    Lacy-Hulbert, A.9
  • 4
    • 0347357773 scopus 로고    scopus 로고
    • IL-23 produced by CNS-resident cells controls Tcell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
    • Becher B., Durell B.G., Noelle R.J. IL-23 produced by CNS-resident cells controls Tcell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J.Clin. Invest. 2003, 112:1186-1191.
    • (2003) J.Clin. Invest. , vol.112 , pp. 1186-1191
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 5
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium (IMSGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)Wellcome Trust Case Control Consortium 2 (WTCCC2), International IBD Genetics Consortium (IIBDGC)International IBD Genetics Consortium (IIBDGC)
    • Beecham A.H., Patsopoulos N.A., Xifara D.K., Davis M.F., Kemppinen A., Cotsapas C., Shah T.S., Spencer C., Booth D., Goris A., et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 2013, 45:1353-1360. International Multiple Sclerosis Genetics Consortium (IMSGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)Wellcome Trust Case Control Consortium 2 (WTCCC2), International IBD Genetics Consortium (IIBDGC)International IBD Genetics Consortium (IIBDGC).
    • (2013) Nat. Genet. , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3    Davis, M.F.4    Kemppinen, A.5    Cotsapas, C.6    Shah, T.S.7    Spencer, C.8    Booth, D.9    Goris, A.10
  • 6
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory Tcells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory Tcells. Nature 2006, 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 7
    • 84866565809 scopus 로고    scopus 로고
    • The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation
    • Chang T.H., Xu S., Tailor P., Kanno T., Ozato K. The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation. J.Immunol. 2012, 189:3548-3556.
    • (2012) J.Immunol. , vol.189 , pp. 3548-3556
    • Chang, T.H.1    Xu, S.2    Tailor, P.3    Kanno, T.4    Ozato, K.5
  • 11
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • International MS Genetics Consortium
    • De Jager P.L., Jia X., Wang J., de Bakker P.I.W., Ottoboni L., Aggarwal N.T., Piccio L., Raychaudhuri S., Tran D., Aubin C., et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 2009, 41:776-782. International MS Genetics Consortium.
    • (2009) Nat. Genet. , vol.41 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3    de Bakker, P.I.W.4    Ottoboni, L.5    Aggarwal, N.T.6    Piccio, L.7    Raychaudhuri, S.8    Tran, D.9    Aubin, C.10
  • 13
    • 79251561555 scopus 로고    scopus 로고
    • IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    • Feng J., Wang H., Shin D.M., Masiuk M., Qi C.F., Morse H.C. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J.Immunol. 2011, 186:1458-1466.
    • (2011) J.Immunol. , vol.186 , pp. 1458-1466
    • Feng, J.1    Wang, H.2    Shin, D.M.3    Masiuk, M.4    Qi, C.F.5    Morse, H.C.6
  • 15
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
    • Hauser S.L., Oksenberg J.R. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006, 52:61-76.
    • (2006) Neuron , vol.52 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 16
    • 84877025203 scopus 로고    scopus 로고
    • Integrin-mediated regulation of TGFβ in fibrosis
    • Henderson N.C., Sheppard D. Integrin-mediated regulation of TGFβ in fibrosis. Biochim. Biophys. Acta 2013, 1832:891-896.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 891-896
    • Henderson, N.C.1    Sheppard, D.2
  • 17
    • 84866673725 scopus 로고    scopus 로고
    • Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
    • Horiuchi M., Wakayama K., Itoh A., Kawai K., Pleasure D., Ozato K., Itoh T. Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia. J.Neuroinflammation 2012, 9:227.
    • (2012) J.Neuroinflammation , vol.9 , pp. 227
    • Horiuchi, M.1    Wakayama, K.2    Itoh, A.3    Kawai, K.4    Pleasure, D.5    Ozato, K.6    Itoh, T.7
  • 18
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 19
    • 58149280443 scopus 로고    scopus 로고
    • Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes
    • Jakubzick C., Bogunovic M., Bonito A.J., Kuan E.L., Merad M., Randolph G.J. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J.Exp. Med. 2008, 205:2839-2850.
    • (2008) J.Exp. Med. , vol.205 , pp. 2839-2850
    • Jakubzick, C.1    Bogunovic, M.2    Bonito, A.J.3    Kuan, E.L.4    Merad, M.5    Randolph, G.J.6
  • 21
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated Tcells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke M.A., Carlson T.J., Andjelkovic A.V., Segal B.M. IL-12- and IL-23-modulated Tcells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J.Exp. Med. 2008, 205:1535-1541.
    • (2008) J.Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 24
    • 33846593869 scopus 로고    scopus 로고
    • Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia
    • Li Y., Chu N., Hu A., Gran B., Rostami A., Zhang G.-X. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain 2007, 130:490-501.
    • (2007) Brain , vol.130 , pp. 490-501
    • Li, Y.1    Chu, N.2    Hu, A.3    Gran, B.4    Rostami, A.5    Zhang, G.-X.6
  • 25
    • 78650178184 scopus 로고    scopus 로고
    • Th1 versus Th17: are Tcell cytokines relevant in multiple sclerosis?
    • Lovett-Racke A.E., Yang Y., Racke M.K. Th1 versus Th17: are Tcell cytokines relevant in multiple sclerosis?. Biochim. Biophys. Acta 2011, 1812:246-251.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 246-251
    • Lovett-Racke, A.E.1    Yang, Y.2    Racke, M.K.3
  • 26
    • 77956546075 scopus 로고    scopus 로고
    • SMAD2 is essential for TGF beta-mediated Th17 cell generation
    • Malhotra N., Robertson E., Kang J. SMAD2 is essential for TGF beta-mediated Th17 cell generation. J.Biol. Chem. 2010, 285:29044-29048.
    • (2010) J.Biol. Chem. , vol.285 , pp. 29044-29048
    • Malhotra, N.1    Robertson, E.2    Kang, J.3
  • 27
    • 84861123981 scopus 로고    scopus 로고
    • IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype
    • Masuda T., Tsuda M., Yoshinaga R., Tozaki-Saitoh H., Ozato K., Tamura T., Inoue K. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep 2012, 1:334-340.
    • (2012) Cell Rep , vol.1 , pp. 334-340
    • Masuda, T.1    Tsuda, M.2    Yoshinaga, R.3    Tozaki-Saitoh, H.4    Ozato, K.5    Tamura, T.6    Inoue, K.7
  • 28
    • 78649807601 scopus 로고    scopus 로고
    • Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice
    • Melton A.C., Bailey-Bucktrout S.L., Travis M.A., Fife B.T., Bluestone J.A., Sheppard D. Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J.Clin. Invest. 2010, 120:4436-4444.
    • (2010) J.Clin. Invest. , vol.120 , pp. 4436-4444
    • Melton, A.C.1    Bailey-Bucktrout, S.L.2    Travis, M.A.3    Fife, B.T.4    Bluestone, J.A.5    Sheppard, D.6
  • 29
    • 84875950146 scopus 로고    scopus 로고
    • IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS
    • Minten C., Terry R., Deffrasnes C., King N.J., Campbell I.L. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PLoS ONE 2012, 7:e49851.
    • (2012) PLoS ONE , vol.7
    • Minten, C.1    Terry, R.2    Deffrasnes, C.3    King, N.J.4    Campbell, I.L.5
  • 30
    • 84864355786 scopus 로고    scopus 로고
    • Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 Tcells
    • Miyagawa F., Zhang H., Terunuma A., Ozato K., Tagaya Y., Katz S.I. Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 Tcells. Proc. Natl. Acad. Sci. USA 2012, 109:12123-12128.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 12123-12128
    • Miyagawa, F.1    Zhang, H.2    Terunuma, A.3    Ozato, K.4    Tagaya, Y.5    Katz, S.I.6
  • 34
    • 34547928758 scopus 로고    scopus 로고
    • Magnetic resonance imaging of blood-spinal cord barrier disruption in mice with experimental autoimmune encephalomyelitis
    • Schellenberg A.E., Buist R., Yong V.W., Del Bigio M.R., Peeling J. Magnetic resonance imaging of blood-spinal cord barrier disruption in mice with experimental autoimmune encephalomyelitis. Magn. Reson. Med. 2007, 58:298-305.
    • (2007) Magn. Reson. Med. , vol.58 , pp. 298-305
    • Schellenberg, A.E.1    Buist, R.2    Yong, V.W.3    Del Bigio, M.R.4    Peeling, J.5
  • 35
    • 78751690657 scopus 로고    scopus 로고
    • Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
    • Shaw P.J., Barr M.J., Lukens J.R., McGargill M.A., Chi H., Mak T.W., Kanneganti T.D. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity 2011, 34:75-84.
    • (2011) Immunity , vol.34 , pp. 75-84
    • Shaw, P.J.1    Barr, M.J.2    Lukens, J.R.3    McGargill, M.A.4    Chi, H.5    Mak, T.W.6    Kanneganti, T.D.7
  • 38
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 2006, 60:12-21.
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 39
    • 40449089827 scopus 로고    scopus 로고
    • Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells
    • Stromnes I.M., Cerretti L.M., Liggitt D., Harris R.A., Goverman J.M. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14:337-342.
    • (2008) Nat. Med. , vol.14 , pp. 337-342
    • Stromnes, I.M.1    Cerretti, L.M.2    Liggitt, D.3    Harris, R.A.4    Goverman, J.M.5
  • 40
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., Villarino A.V., Huang Q., Yoshimura A., Sehy D., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 2006, 7:937-945.
    • (2006) Nat. Immunol. , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6    Villarino, A.V.7    Huang, Q.8    Yoshimura, A.9    Sehy, D.10
  • 41
    • 0031048823 scopus 로고    scopus 로고
    • Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1
    • Tada Y., Ho A., Matsuyama T., Mak T.W. Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J.Exp. Med. 1997, 185:231-238.
    • (1997) J.Exp. Med. , vol.185 , pp. 231-238
    • Tada, Y.1    Ho, A.2    Matsuyama, T.3    Mak, T.W.4
  • 42
    • 41349119601 scopus 로고    scopus 로고
    • The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse
    • Tailor P., Tamura T., Morse H.C., Ozato K. The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood 2008, 111:1942-1945.
    • (2008) Blood , vol.111 , pp. 1942-1945
    • Tailor, P.1    Tamura, T.2    Morse, H.C.3    Ozato, K.4
  • 43
    • 14044270784 scopus 로고    scopus 로고
    • IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity
    • Tamura T., Tailor P., Yamaoka K., Kong H.J., Tsujimura H., O'Shea J.J., Singh H., Ozato K. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J.Immunol. 2005, 174:2573-2581.
    • (2005) J.Immunol. , vol.174 , pp. 2573-2581
    • Tamura, T.1    Tailor, P.2    Yamaoka, K.3    Kong, H.J.4    Tsujimura, H.5    O'Shea, J.J.6    Singh, H.7    Ozato, K.8
  • 45
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen M., Hocking R.J., Flavell R.A., Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 2006, 7:1151-1156.
    • (2006) Nat. Immunol. , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 46
    • 84864124859 scopus 로고    scopus 로고
    • IL-12 family cytokines: immunological playmakers
    • Vignali D.A., Kuchroo V.K. IL-12 family cytokines: immunological playmakers. Nat. Immunol. 2012, 13:722-728.
    • (2012) Nat. Immunol. , vol.13 , pp. 722-728
    • Vignali, D.A.1    Kuchroo, V.K.2
  • 47
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector Tcell lineages
    • Weaver C.T., Hatton R.D., Mangan P.R., Harrington L.E. IL-17 family cytokines and the expanding diversity of effector Tcell lineages. Annu. Rev. Immunol. 2007, 25:821-852.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 49
    • 77954359269 scopus 로고    scopus 로고
    • Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    • Zhang J., Qian X., Ning H., Yang J., Xiong H., Liu J. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. J.Biol. Chem. 2010, 285:21269-21281.
    • (2010) J.Biol. Chem. , vol.285 , pp. 21269-21281
    • Zhang, J.1    Qian, X.2    Ning, H.3    Yang, J.4    Xiong, H.5    Liu, J.6


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