Resveratrol directly binds to mitochondrial complex i and increases oxidative stress in brain mitochondria of aged mice

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Gueguen, Naïg ^a,b,c   Desquiret Dumas, Valérie ^a,b,c   Leman, Géraldine ^a,c   Chupin, Stéphanie ^a,b,c   Baron, Stéphanie ^d   Nivet Antoine, Valérie ^d   Vessières, Emilie ^a,c   Ayer, Audrey ^a,c   Henrion, Daniel ^a,c   Lenaers, Guy ^a,c   Reynier, Pascal ^a,b,c   Procaccio, Vincent ^a,b,c  

^a UNIVERSITÉ D'ANGERS   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESVERATROL; NICOTINAMIDE ADENINE DINUCLEOTIDE; STILBENE DERIVATIVE;

AGED; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; BRAIN MITOCHONDRION; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; JUVENILE ANIMAL; MALE; MITOCHONDRIAL RESPIRATION; MOLECULAR DOCKING; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; SEQUENCE ANALYSIS; AGE; ANIMAL; BRAIN; CELL CULTURE; CELL RESPIRATION; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; MOLECULAR MODEL;

AGE FACTORS; ANIMALS; BINDING SITES; BRAIN; CELL RESPIRATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; MICE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NAD; OXIDATIVE STRESS; STILBENES;

EID: 84956901471     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144290     Document Type: Article

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