Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 5, 2006, Pages 1437-1443

  Fukuhara, Kiyoshi ^a   Nagakawa, Maki ^b   Nakanishi, Ikuo ^c,d   Ohkubo, Kei ^d   Imai, Kohei ^e   Urano, Shiro ^e   Fukuzumi, Shunichi ^d   Ozawa, Toshihiko ^c   Ikota, Nobuo ^c   Mochizuki, Masataka ^b   Miyata, Naoki ^f   Okuda, Haruhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e SHIBAURA INSTITUTE OF TECHNOLOGY   (Japan)

^f NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Antioxidant; DNA oxidative damage; Polyphenol; Resveratrol

Indexed keywords

4 HYDROXYSTILBENE; ANTIOXIDANT; CUPRIC ION; HYDROXYL GROUP; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DNA STRUCTURE; ENZYME SPECIFICITY; GENOTOXICITY; GRAPE; HUMAN; IN VITRO STUDY; MICRONUCLEUS; NONHUMAN; SISTER CHROMATID EXCHANGE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BINDING SITES; CATIONS, DIVALENT; COPPER; DNA; DNA DAMAGE; HYDROXYL RADICAL; REACTIVE OXYGEN SPECIES; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

VITACEAE; VITIS SP.;

EID: 31044444909     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.070     Document Type: Article

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