Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 100, Issue , 2016, Pages 38-46

  Sreedhara, Alavattam ^a   Yin, Jian ^a   Joyce, Michael ^a   Lau, Kimberly ^a   Wecksler, Aaron T ^a   Deperalta, Galahad ^a   Yi, Li ^a   Wang, Y John ^a   Kabakoff, Bruce ^a   Kishore, Ravuri S K ^b  

^a GENENTECH INC   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Ambient light; Drug product processing; HunterLab; Mild light; Photodegradation; Photooxidation; Photostability; Relevant stress

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; TRYPTOPHAN; IMMUNOGLOBULIN G;

ANIMAL CELL; ARTICLE; COLOR; CONTROLLED STUDY; DRUG DESIGN; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PRODUCT PROCESSING; DRUG STABILITY; FEMALE; IN VITRO STUDY; LIGHT EXPOSURE; NONHUMAN; PHOTOCHEMISTRY; PHOTOOXIDATION; PHOTOSTABILITY; PROTEIN AGGREGATION; ULTRAVIOLET RADIATION; WHITE LIGHT; ADVERSE EFFECTS; CHEMISTRY; DRUG DEVELOPMENT; LIGHT; MEDICINAL CHEMISTRY; OXIDATION REDUCTION REACTION; PROCEDURES; RADIATION RESPONSE;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; DRUG STABILITY; IMMUNOGLOBULIN G; LIGHT; OXIDATION-REDUCTION;

EID: 84955583891     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.12.003     Document Type: Article

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