Photodegradation of human growth hormone: A novel backbone cleavage between Glu-88 and Pro-89

Molecular Pharmaceutics

Volumn 10, Issue 7, 2013, Pages 2693-2706

  Steinmann, Daniel ^a   Ji, J Andrea ^b   Wang, Y John ^b   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b GENENTECH INC   (United States)

Author keywords

hGH; human growth hormone; peptide cleavage; photostability; protein degradation; somatropin

Indexed keywords

GLUTAMATE 88; GLUTAMIC ACID; HUMAN GROWTH HORMONE; PROLINE; PROLINE 89; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HORMONE STRUCTURE; HUMAN; IRRADIATION; LIQUID CHROMATOGRAPHY; OXIDATION; PHOTODEGRADATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTON TRANSPORT; TANDEM MASS SPECTROMETRY;

GLUTAMIC ACID; HUMAN GROWTH HORMONE; HUMANS; MOLECULAR STRUCTURE; PHOTOLYSIS; PROLINE;

EID: 84879714299     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400128j     Document Type: Article

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