Effect of ambient light on monoclonal antibody product quality during small-scale mammalian cell culture process in clear glass bioreactors

Biotechnology Progress

Volumn 30, Issue 3, 2014, Pages 562-570

  Mallaney, Mary ^a   Wang, Szu Han ^a   Sreedhara, Alavattam ^a  

^a GENENTECH INC   (United States)

Author keywords

Acidic variants; CHO cells; Glass bioreactors; Mammalian cell culture; Monoclonal antibodies; Photosensitivity; Protein oxidation; Reactive oxygen species

Indexed keywords

ANIMAL CELL CULTURE; BIOCONVERSION; BIOREACTORS; CELLS; GLASS; MAMMALS; MONOCLONAL ANTIBODIES; PHOTOSENSITIVITY; REACTIVE OXYGEN SPECIES; SULFUR COMPOUNDS;

ACIDIC VARIANTS; CELL CULTURE PROCESS; CHO CELL; FORMULATION BUFFERS; MAMMALIAN CELL CULTURE; MONOCLONAL ANTIBODY PRODUCTION; PROTEIN OXIDATION; TRANSPARENT GLASS;

GLASS INDUSTRY;

MAMMALIA;

CULTURE MEDIUM; MONOCLONAL ANTIBODY;

ANIMAL; BIOREACTOR; BIOSYNTHESIS; CHO CELL LINE; CRICETULUS; CULTURE MEDIUM; CULTURE TECHNIQUE; LIGHT; MAMMAL; RADIATION RESPONSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETULUS; CULTURE MEDIA; LIGHT; MAMMALS;

EID: 84922949925     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1920     Document Type: Article

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