Characterization of the degradation products of a color-changed monoclonal antibody: Tryptophan-derived chromophores

Analytical Chemistry

Volumn 86, Issue 14, 2014, Pages 6850-6857

  Li, Yiming ^a   Polozova, Alla ^a,b   Gruia, Flaviu ^a   Feng, Jinhua ^a  

^a MEDIMMUNE   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOPHORES; COLORIMETRY; DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAPPING; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OXIDATION; PEPTIDES;

DEGRADATION PRODUCTS; LIQUID FORMULATIONS; MAXIMUM ABSORBANCE; MONOCLONAL ANTIBODIES (MAB); OXIDATION PRODUCTS; REVERSED PHASE HPLC; TRYPTOPHAN OXIDATION; TRYPTOPHAN RESIDUES;

AMINO ACIDS;

5 HYDROXYTRYPTOPHAN; KYNURENINE; METHIONINE; MONOCLONAL ANTIBODY; N'-FORMYLKYNURENINE; TRYPTOPHAN;

ANALOGS AND DERIVATIVES; CHEMISTRY; COLOR; DEVICES; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; PEPTIDE MAPPING; PROCEDURES; ULTRAVIOLET RADIATION; ULTRAVIOLET SPECTROPHOTOMETRY;

5-HYDROXYTRYPTOPHAN; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLOR; HOT TEMPERATURE; KYNURENINE; MASS SPECTROMETRY; METHIONINE; OXIDATION-REDUCTION; PEPTIDE MAPPING; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPTOPHAN; ULTRAVIOLET RAYS;

EID: 84904357557     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac404218t     Document Type: Article

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