Effect of polysorbate 80 quality on photostability of a monoclonal antibody

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 422-430

  Singh, Swita R ^a   Zhang, Jingming ^a   O'Dell, Courtney ^a   Hsieh, Ming Ching ^a   Goldstein, Joel ^a   Liu, Joseph ^a   Srivastava, Arvind ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

antibody; photostability; polysorbate 80; protein stability; Super Refined Polysorbate 80

Indexed keywords

MONOCLONAL ANTIBODY; POLYSORBATE 80;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG FORMULATION; DRUG OXIDATION; DRUG PURITY; DRUG STABILITY; LIGHT EXPOSURE; MOLECULAR WEIGHT; PEPTIDE MAPPING; PHOTOOXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; DRUG STABILITY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EXCIPIENTS; LIGHT; MOLECULAR WEIGHT; OXIDATION-REDUCTION; PEPTIDE MAPPING; PEROXIDES; PHOTOLYSIS; POLYSORBATES; PROTEIN STABILITY; QUALITY CONTROL; TANDEM MASS SPECTROMETRY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84862845539     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9759-6     Document Type: Article

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