Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 278-288

  Sreedhara, Alavattam ^a   Lau, Kimberly ^a   Li, Charlene ^a   Hosken, Brian ^a   MacChi, Frank ^a   Zhan, Dejin ^a   Shen, Amy ^a   Steinmann, Daniel ^b   Schöneich, Christian ^b   Lentz, Yvonne ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

immunoglobulins; integrating sphere; monoclonal antibodies; photo oxidation; quantum yield; reactive oxygen species; singlet oxygen; superoxide; tryptophan

Indexed keywords

HYDROGEN PEROXIDE; MONOCLONAL ANTIBODY; OXYGEN; REACTIVE OXYGEN METABOLITE; TRYPTOPHAN DERIVATIVE; WATER;

ANIMAL CELL; ANTIBODY CATALYZED WATER OXIDATION PATHWAY; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENERGY; FEMALE; LIGHT; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PHOTOOXIDATION; PRIORITY JOURNAL; REDUCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SURFACE PROPERTY;

ANIMALS; ANTIBODIES, CATALYTIC; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; HYDROGEN PEROXIDE; LIGHT; MODELS, MOLECULAR; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN; SUPEROXIDES; TRYPTOPHAN; WATER;

EID: 84872140390     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300418r     Document Type: Article

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