Site-specific tryptophan oxidation induced by autocatalytic reaction of polysorbate 20 in protein formulation

Pharmaceutical Research

Volumn 28, Issue 10, 2011, Pages 2543-2555

  Lam, Xanthe M ^a   Lai, William G ^a   Chan, Edwin K ^a   Ling, Victor ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

autocatalytic reaction kinetics; free radicals; peroxides; polysorbate 20; tryptophan oxidation

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CATALASE; EDETIC ACID; FREE RADICAL; HISTIDINE; IMMUNOGLOBULIN F(AB) FRAGMENT; PEROXIDE; POLYSORBATE 20; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG FORMULATION; DRUG STORAGE; ELECTRON SPIN RESONANCE; FLUOROMETRY; ION EXCHANGE CHROMATOGRAPHY; OXIDATION KINETICS; PEPTIDE MAPPING; PRIORITY JOURNAL; STORAGE TEMPERATURE;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, ION EXCHANGE; FREE RADICALS; HISTIDINE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDE MAPPING; PEROXIDES; POLYSORBATES; TRYPTOPHAN;

EID: 80054773616     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0482-x     Document Type: Article

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