Oxytocin in General Anxiety and Social Fear: A Translational Approach

Biological Psychiatry

Volumn 79, Issue 3, 2016, Pages 213-221

  Neumann, Inga D ^a   Slattery, David A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Amygdala; Anxiety; Fear; Human; Rodent; Social anxiety

Indexed keywords

ATOSIBAN; CARBETOCIN; OXYTOCIN;

BASOLATERAL AMYGDALA; CENTRAL NUCLEUS (AMYGDALA); DOSE RESPONSE; FEAR CONDITIONING TEST; GENERALIZED ANXIETY DISORDER; HUMAN; INFRALIMBIC CORTEX; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRELIMBIC CORTEX; PRIORITY JOURNAL; REVIEW; SOCIAL BEHAVIOR; SOCIAL PHOBIA; TRANQUILIZING ACTIVITY; ANXIETY; FEAR; METABOLISM; PHOBIA; PHYSIOLOGY; PSYCHOLOGY;

ANXIETY; FEAR; HUMANS; OXYTOCIN; PHOBIC DISORDERS; SOCIAL BEHAVIOR;

EID: 84955582927     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.06.004     Document Type: Review

References (117)

1. R.C. Kessler, and P.S. Wang The descriptive epidemiology of commonly occurring mental disorders in the United States Annu Rev Public Health 29 2008 115 129
2. J. Alonso, M. Petukhova, G. Vilagut, S. Chatterji, S. Heeringa, T.B. Ustun, and et al. Days out of role due to common physical and mental conditions: Results from the WHO World Mental Health surveys Mol Psychiatry 16 2011 1234 1246
3. R.C. Kessler, M. Petukhova, N.A. Sampson, A.M. Zaslavsky, and H.U. Wittchen Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States Int J Methods Psychiatr Res 21 2012 169 184
4. I. Toth, and I.D. Neumann Animal models of social avoidance and social fear Cell Tissue Res 354 2013 107 118
5. S.M. Bogels, L. Alden, D.C. Beidel, L.A. Clark, D.S. Pine, M.B. Stein, and M. Voncken Social anxiety disorder: Questions and answers for the DSM-V Depress Anxiety 27 2010 168 189
6. J.A. den Boer Social phobia: Epidemiology, recognition, and treatment BMJ 315 1997 796 800
7. R.C. Kessler, M.B. Stein, and P. Berglund Social phobia subtypes in the National Comorbidity Survey Am J Psychiatry 155 1998 613 619
8. M.A. Ruipérez, A. Garcia-Palacios, and C. Botella Clinical features and treatment response in social phobia: Axis II comorbidity and social phobia subtypes Psicothema 14 2002 426 433
9. M.J. Chartier, J.R. Walker, and M.B. Stein Considering comorbidity in social phobia Soc Psychiatry Psychiatr Epidemiol 38 2003 728 734
10. F.R. Schneier, T.E. Foose, D.S. Hasin, R.G. Heimberg, S.M. Liu, B.F. Grant, and C. Blanco Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions Psychol Med 40 2010 977 988
11. C. Blanco, L.B. Bragdon, F.R. Schneier, and M.R. Liebowitz The evidence-based pharmacotherapy of social anxiety disorder Int J Neuropsychopharmacol 16 2013 235 249
12. R. Landgraf, R. Gerstberger, A. Montkowski, J.C. Probst, C.T. Wotjak, F. Holsboer, and M. Engelmann V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats J Neurosci 15 1995 4250 4258
13. E. Frank, and R. Landgraf The vasopressin system - from antidiuresis to psychopathology Eur J Pharmacol 583 2008 226 242
14. R. Landgraf, and I.D. Neumann Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication Front Neuroendocrinol 25 2004 150 176
15. G. Wu, A. Feder, G. Wegener, C. Bailey, S. Saxena, D. Charney, and A.A. Mathé Central functions of neuropeptide Y in mood and anxiety disorders Expert Opin Ther Targets 15 2011 1317 1331
16. D.A. Slattery, R.R. Naik, T. Grund, Y.-C. Yen, S.B. Sartori, A. Füchsl, and et al. Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity J Neurosci 35 2015 4599 4613
17. S. Meis, J.R. Bergado-Acosta, Y. Yanagawa, K. Obata, O. Stork, and T. Munsch Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus PLoS One 3 2008 e2695
18. M. Lukas, and I.D. Neumann Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: Social versus non-social effects Neuropharmacology 62 2012 398 405
19. C.A. Pedersen, and A.J. Prange Jr Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin Proc Natl Acad Sci U S A 76 1979 6661 6665
20. D. De Wied The influence of the posterior and intermediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats Int J Neuropharmacol 4 1965 157 167
21. I.D. Neumann, and R. Landgraf Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors Trends Neurosci 35 2012 649 659
22. K. MacDonald, and D. Feifel Oxytocin's role in anxiety: A critical appraisal Brain Res 1580 2014 22 56
23. A. Meyer-Lindenberg, G. Domes, P. Kirsch, and M. Heinrichs Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine Nat Rev Neurosci 12 2011 524 538
24. C.H. Rhodes, J.I. Morrell, and D.W. Pfaff Immunohistochemical analysis of magnocellular elements in rat hypothalamus: Distribution and numbers of cells containing neurophysin, oxytocin, and vasopressin J Comp Neurol 198 1981 45 64
25. G.J. De Vries, and R.M. Buijs The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum Brain Res 273 1983 307 317
26. H.S. Knobloch, and V. Grinevich Evolution of oxytocin pathways in the brain of vertebrates Front Behav Neurosci 8 2014 31
27. I.D. Neumann Stimuli and consequences of dendritic release of oxytocin within the brain Biochem Soc Trans 35 2007 1252 1257
28. G. Gimpl, and F. Fahrenholz The oxytocin receptor system: Structure, function, and regulation Physiol Rev 81 2001 629 683
29. E.H. van den Burg, and I.D. Neumann Bridging the gap between GPCR activation and behaviour: Oxytocin and prolactin signalling in the hypothalamus J Mol Neurosci 43 2011 200 208
30. D.M. Gibbs Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress Life Sci 35 1984 487 491
31. T.D. Williams, D.A. Carter, and S.L. Lightman Sexual dimorphism in the posterior pituitary response to stress in the rat Endocrinology 116 1985 738 740
32. R.E. Lang, J.W. Heil, D. Ganten, K. Hermann, T. Unger, and W. Rascher Oxytocin unlike vasopressin is a stress hormone in the rat Neuroendocrinology 37 1983 314 316
33. T. Onaka, and K. Yagi Effects of novelty stress on vasopressin and oxytocin secretion by the pituitary in the rat J Neuroendocrinol 5 1993 365 369
34. D. Jezova, I. Skultetyova, D.I. Tokarev, P. Bakos, and M. Vigas Vasopressin and oxytocin in stress Ann N Y Acad Sci 771 1995 192 203
35. C.T. Wotjak, J. Ganster, G. Kohl, F. Holsboer, R. Landgraf, and M. Engelmann Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons Neuroscience 85 1998 1209 1222
36. M. Engelmann, R. Landgraf, and C.T. Wotjak The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: An old concept revisited Front Neuroendocrinol 25 2004 132 149
37. I.D. Neumann, N. Toschi, F. Ohl, L. Torner, and S.A. Kromer Maternal defence as an emotional stressor in female rats: Correlation of neuroendocrine and behavioural parameters and involvement of brain oxytocin Eur J Neurosci 13 2001 1016 1024
38. O.J. Bosch, S.A. Kromer, P.J. Brunton, and I.D. Neumann Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence Neuroscience 124 2004 439 448
39. H.S. Knobloch, A. Charlet, L.C. Hoffmann, M. Eliava, S. Khrulev, A.H. Cetin, and et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response Neuron 73 2012 553 566
40. M. Ludwig, and G. Leng Dendritic peptide release and peptide-dependent behaviours Nat Rev Neurosci 7 2006 126 136
41. M. Engelmann, K. Ebner, R. Landgraf, F. Holsboer, and C.T. Wotjak Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats J Neuroendocrinol 11 1999 867 872
42. M. Ludwig, M.F. Callahan, I. Neumann, R. Landgraf, and M. Morris Systemic osmotic stimulation increases vasopressin and oxytocin release within the supraoptic nucleus J Neuroendocrinol 6 1994 369 373
43. I. Neumann, R. Landgraf, L. Bauce, and Q.J. Pittman Osmotic responsiveness and cross talk involving oxytocin, but not vasopressin or amino acids, between the supraoptic nuclei in virgin and lactating rats J Neurosci 15 1995 3408 3417
44. R. Landgraf, R. Hacker, and H. Buhl Plasma vasopressin and oxytocin in response to exercise and during a day-night cycle in man Endokrinologie 79 1982 281 291
45. B. Pierrehumbert, R. Torrisi, F. Ansermet, A. Borghini, and O. Halfon Adult attachment representations predict cortisol and oxytocin responses to stress Attach Hum Dev 14 2012 453 476
46. D.S. Carson, S.W. Berquist, T.H. Trujillo, J.P. Garner, S.L. Hannah, S.A. Hyde, and et al. Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children Mol Psychiatry 20 2015 1085 1090
47. J. Holt-Lunstad, W. Birmingham, and K.C. Light The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention Psychoneuroendocrinology 36 2011 1249 1256
48. A.S. Suraev, M.T. Bowen, S.O. Ali, C. Hicks, L. Ramos, and I.S. McGregor Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood Horm Behav 65 2014 488 496
49. K.J. Robinson, N. Hazon, M. Lonergan, and P.P. Pomeroy Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure J Neurosci Methods 226 2014 73 79
50. G. Leng, and M. Ludwig Intranasal oxytocin: Myths and delusions Biol Psychiatry 79 2016 243 250
51. I.D. Neumann, L. Torner, and A. Wigger Brain oxytocin: Differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats Neuroscience 95 2000 567 575
52. I.D. Neumann, A. Wigger, L. Torner, F. Holsboer, and R. Landgraf Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: Partial action within the paraventricular nucleus J Neuroendocrinol 12 2000 235 243
53. T.L. Bale, A.M. Davis, A.P. Auger, D.M. Dorsa, and M.M. McCarthy CNS region-specific oxytocin receptor expression: Importance in regulation of anxiety and sex behavior J Neurosci 21 2001 2546 2552
54. A. Blume, O.J. Bosch, S. Miklos, L. Torner, L. Wales, M. Waldherr, and I.D. Neumann Oxytocin reduces anxiety via ERK1/2 activation: Local effect within the rat hypothalamic paraventricular nucleus Eur J Neurosci 27 2008 1947 1956
55. R.H. Ring, J.E. Malberg, L. Potestio, J. Ping, S. Boikess, B. Luo, and et al. Anxiolytic-like activity of oxytocin in male mice: Behavioral and autonomic evidence, therapeutic implications Psychopharmacology (Berl) 185 2006 218 225
56. P. Mak, C. Broussard, K. Vacy, and J.H. Broadbear Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat J Psychopharmacol 26 2012 532 542
57. B. Jurek, D.A. Slattery, R. Maloumby, K. Hillerer, S. Koszinowski, I.D. Neumann, and E.H. van den Burg Differential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats PLoS One 7 2012 e37060
58. S. Sabihi, N.E. Durosko, S.M. Dong, and B. Leuner Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats Psychoneuroendocrinology 45 2014 31 42
59. I. Neumann, J.A. Russell, and R. Landgraf Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: A microdialysis study Neuroscience 53 1993 65 75
60. M. Waldherr, and I.D. Neumann Centrally released oxytocin mediates mating-induced anxiolysis in male rats Proc Natl Acad Sci U S A 104 2007 16681 16684
61. M. Waldherr, K. Nyuyki, R. Maloumby, O.J. Bosch, and I.D. Neumann Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats Horm Behav 57 2010 222 229
62. K.D. Nyuyki, M. Waldherr, S. Baeuml, and I.D. Neumann Yes, I am ready now: Differential effects of paced versus unpaced mating on anxiety and central oxytocin release in female rats PLoS One 6 2011 e23599
63. J.A. Amico, R.C. Mantella, R.R. Vollmer, and X. Li Anxiety and stress responses in female oxytocin deficient mice J Neuroendocrinol 16 2004 319 324
64. E.H. van den Burg, J. Stindl, T. Grund, I.D. Neumann, and O. Strauss Oxytocin stimulates extracellular Ca2+ influx through TRPV2 channels in hypothalamic neurons to exert its anxiolytic effects Neuropsychopharmacology 40 2015 2938 2947
65. D.A. Slattery, and I.D. Neumann Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats Neuropharmacology 58 2010 56 61
66. R.J. Windle, Y.M. Kershaw, N. Shanks, S.A. Wood, S.L. Lightman, and C.D. Ingram Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity J Neurosci 24 2004 2974 2982
67. S. Peters, D.A. Slattery, N. Uschold-Schmidt, S.O. Reber, and I.D. Neumann Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice Psychoneuroendocrinology 42 2014 225 236
68. H. Huang, C. Michetti, M. Busnelli, F. Manago, S. Sannino, D. Scheggia, and et al. Chronic and acute intranasal oxytocin produce divergent social effects in mice Neuropsychopharmacology 39 2014 1102 1114
69. T. Havranek, M. Zatkova, Z. Lestanova, Z. Bacova, B. Mravec, J. Hodosy, and et al. Intracerebroventricular oxytocin administration in rats enhances object recognition and increases expression of neurotrophins, microtubule-associated protein 2, and synapsin I. J Neurosci Res 93 2015 893 901
70. K.L. Bales, A.M. Perkeybile, O.G. Conley, M.H. Lee, C.D. Guoynes, G.M. Downing, and et al. Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles Biol Psychiatry 74 2013 180 188
71. K.L. Bales, M. Solomon, S. Jacob, J.N. Crawley, J.L. Silverman, R.H. Larke, and et al. Long-term exposure to intranasal oxytocin in a mouse autism model Transl Psychiatry 4 2014 e480
72. R.J. Windle, N. Shanks, S.L. Lightman, and C.D. Ingram Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats Endocrinology 138 1997 2829 2834
73. R. Landgraf, and A. Wigger Born to be anxious: Neuroendocrine and genetic correlates of trait anxiety in HAB rats Stress 6 2003 111 119
74. F. Conti, S. Sertic, A. Reversi, and B. Chini Intracellular trafficking of the human oxytocin receptor: Evidence of receptor recycling via a Rab4/Rab5 "short cycle" Am J Physiol Endocrinol Metab 296 2009 E532 E542
75. B. Chini, and M. Manning Agonist selectivity in the oxytocin/vasopressin receptor family: New insights and challenges Biochem Soc Trans 35 2007 737 741
76. M. Tops, J.M. van Peer, J. Korf, A.A. Wijers, and D.M. Tucker Anxiety, cortisol, and attachment predict plasma oxytocin Psychophysiology 44 2007 444 449
77. O. Weisman, O. Zagoory-Sharon, I. Schneiderman, I. Gordon, and R. Feldman Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety Psychoneuroendocrinology 38 2013 694 701
78. B. Costa, S. Pini, P. Gabelloni, M. Abelli, L. Lari, A. Cardini, and et al. Oxytocin receptor polymorphisms and adult attachment style in patients with depression Psychoneuroendocrinology 34 2009 1506 1514
79. R.J. Thompson, K.J. Parker, J.F. Hallmayer, C.E. Waugh, and I.H. Gotlib Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls Psychoneuroendocrinology 36 2011 144 147
80. A.J. Myers, L. Williams, J.M. Gatt, E.Z. McAuley-Clark, C. Dobson-Stone, P.R. Schofield, and C.B. Nemeroff Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress J Psychiatr Res 59 2014 93 100
81. D. Feifel, K. MacDonald, R. McKinney, N. Heisserer, and V. Serrano A randomized, placebo-controlled investigation of intranasal oxytocin in patients with anxiety Neuropsychopharmacology 36 2011 S324 S449
82. G.A. Alvares, N.T. Chen, B.W. Balleine, I.B. Hickie, and A.J. Guastella Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males Psychoneuroendocrinology 37 2012 2022 2031
83. D.C. de Oliveira, A.W. Zuardi, F.G. Graeff, R.H. Queiroz, and J.A. Crippa Anxiolytic-like effect of oxytocin in the simulated public speaking test J Psychopharmacol 26 2012 497 504
84. B.R. Goodin, A.J. Anderson, E.L. Freeman, H.W. Bulls, M.T. Robbins, and T.J. Ness Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states [published online ahead of print November 3] Clin J Pain 2014
85. M. Heinrichs, T. Baumgartner, C. Kirschbaum, and U. Ehlert Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress Biol Psychiatry 54 2003 1389 1398
86. B. Pierrehumbert, R. Torrisi, D. Laufer, O. Halfon, F. Ansermet, and M. Beck Popovic Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence Neuroscience 166 2010 168 177
87. L.M. Shin, S.P. Orr, M.A. Carson, S.L. Rauch, M.L. Macklin, N.B. Lasko, and et al. Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD Arch Gen Psychiatry 61 2004 168 176
88. L.M. Williams, A.H. Kemp, K. Felmingham, M. Barton, G. Olivieri, A. Peduto, and et al. Trauma modulates amygdala and medial prefrontal responses to consciously attended fear Neuroimage 29 2006 347 357
89. C.A. Orsini, and S. Maren Neural and cellular mechanisms of fear and extinction memory formation Neurosci Biobehav Rev 36 2012 1773 1802
90. N. Singewald, C. Schmuckermair, N. Whittle, A. Holmes, and K.J. Ressler Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders Pharmacol Ther 149 2015 150 190
91. M. Cammarota, L.R. Bevilaqua, M.R. Vianna, J.H. Medina, and I. Izquierdo The extinction of conditioned fear: Structural and molecular basis and therapeutic use Rev Bras Psiquiatr 29 2007 80 85
92. G.J. Quirk, D. Pare, R. Richardson, C. Herry, M.H. Monfils, D. Schiller, and A. Vicentic Erasing fear memories with extinction training J Neurosci 30 2010 14993 14997
93. L. Zhu, and T. Onaka Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli Eur J Neurosci 16 2002 2186 2198
94. I. Toth, I.D. Neumann, and D.A. Slattery Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner Psychopharmacology (Berl) 223 2012 149 158
95. N. Lahoud, and M. Maroun Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction Psychoneuroendocrinology 38 2013 2184 2195
96. D. Huber, P. Veinante, and R. Stoop Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala Science 308 2005 245 248
97. D. Viviani, A. Charlet, E. van den Burg, C. Robinet, N. Hurni, M. Abatis, and et al. Oxytocin selectively gates fear responses through distinct outputs from the central amygdala Science 333 2011 104 107
98. I.D. Neumann The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood Front Neuroendocrinol 30 2009 483 496
99. Z.R. Donaldson, and L.J. Young Oxytocin, vasopressin, and the neurogenetics of sociality Science 322 2008 900 904
100. M. Lukas, and I.D. Neumann Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders Behav Brain Res 251 2013 85 94
101. M. Lukas, I. Toth, S.O. Reber, D.A. Slattery, A.H. Veenema, and I.D. Neumann The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice Neuropsychopharmacology 36 2011 2159 2168
102. I. Zoicas, D.A. Slattery, and I.D. Neumann Brain oxytocin in social fear conditioning and its extinction: Involvement of the lateral septum Neuropsychopharmacology 39 2014 3027 3035
103. J.N. Crawley, T. Chen, A. Puri, R. Washburn, T.L. Sullivan, J.M. Hill, and et al. Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments Neuropeptides 41 2007 145 163
104. I. Toth, I.D. Neumann, and D.A. Slattery Social fear conditioning as an animal model of social anxiety disorder Curr Protoc Neurosci Chapter 9 2013 Unit9.42
105. I. Toth, I.D. Neumann, and D.A. Slattery Social fear conditioning: A novel and specific animal model to study social anxiety disorder Neuropsychopharmacology 37 2012 1433 1443
106. Y. Litvin, G. Murakami, and D.W. Pfaff Effects of chronic social defeat on behavioral and neural correlates of sociality: Vasopressin, oxytocin and the vasopressinergic V1b receptor Physiol Behav 103 2011 393 403
107. Y.F. Guzman, N.C. Tronson, V. Jovasevic, K. Sato, A.L. Guedea, H. Mizukami, and et al. Fear-enhancing effects of septal oxytocin receptors Nat Neurosci 16 2013 1185 1187
108. R.K. Pitman, S.P. Orr, and N.B. Lasko Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder Psychiatry Res 48 1993 107 117
109. M. Eckstein, B. Becker, D. Scheele, C. Scholz, K. Preckel, T.E. Schlaepfer, and et al. Oxytocin facilitates the extinction of conditioned fear in humans Biol Psychiatry 78 2015 194 202
110. D. Acheson, D. Feifel, S. de Wilde, R. McKinney, J. Lohr, and V. Risbrough The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample Psychopharmacology (Berl) 229 2013 199 208
111. C. Grillon, M. Krimsky, D.R. Charney, K. Vytal, M. Ernst, and B. Cornwell Oxytocin increases anxiety to unpredictable threat Mol Psychiatry 18 2013 958 960
112. C. Ziegler, U. Dannlowski, D. Brauer, S. Stevens, I. Laeger, H. Wittmann, and et al. Oxytocin receptor gene methylation: Converging multilevel evidence for a role in social anxiety Neuropsychopharmacology 40 2015 1528 1538
113. A.J. Guastella, A.L. Howard, M.R. Dadds, P. Mitchell, and D.S. Carson A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder Psychoneuroendocrinology 34 2009 917 923
114. S. Dodhia, A. Hosanagar, D.A. Fitzgerald, I. Labuschagne, A.G. Wood, P.J. Nathan, and K.L. Phan Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder Neuropsychopharmacology 39 2014 2061 2069
115. S.M. Gorka, D.A. Fitzgerald, I. Labuschagne, A. Hosanagar, A.G. Wood, P.J. Nathan, and K.L. Phan Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder Neuropsychopharmacology 40 2015 278 286
116. I. Labuschagne, K.L. Phan, A. Wood, M. Angstadt, P. Chua, M. Heinrichs, and et al. Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder Neuropsychopharmacology 35 2010 2403 2413
117. S.S. Hall, A.A. Lightbody, B.E. McCarthy, K.J. Parker, and A.L. Reiss Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome Psychoneuroendocrinology 37 2012 509 518