Regional Cerebral Blood Flow in the Amygdala and Medial Prefrontal Cortex during Traumatic Imagery in Male and Female Vietnam Veterans with PTSD

Archives of General Psychiatry

Volumn 61, Issue 2, 2004, Pages 168-176

  Shin, Lisa M ^a,b   Orr, Scott P ^b,c   Carson, Margaret A ^c,d   Rauch, Scott L ^b   Macklin, Michael L ^c   Lasko, Natasha B ^b,c   Peters, Patricia Marzol ^b,e   Metzger, Linda J ^b,c   Dougherty, Darin D ^b   Cannistraro, Paul A ^b   Alpert, Nathaniel M ^b   Fischman, Alan J ^b   Pitman, Roger K ^b  

^a TUFTS UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c VA Research Service   (United States)

^d SAINT ANSELM COLLEGE   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; FEMALE; FRONTAL LOBE; HUMAN; IMAGERY; MALE; NURSE; POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PSYCHOPHYSIOLOGY; SELF REPORT; SOLDIER; VIET NAM;

AMYGDALA; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMAGERY (PSYCHOTHERAPY); MALE; MIDDLE AGED; PREFRONTAL CORTEX; REGIONAL BLOOD FLOW; STRESS DISORDERS, POST-TRAUMATIC; TOMOGRAPHY, EMISSION-COMPUTED; VETERANS; VIETNAM; WAR; WOUNDS AND INJURIES;

EID: 9144262943     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.61.2.168     Document Type: Article

References (41)

1. Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM. Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry. 1999;45:817-826.
2. Pissiota A, Frans O, Fernandez M, von Knorring L, Fischer H, Fredrikson M. Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study. Eur Arch Psychiatry Clin Neurosci. 2002;252:68-75.
3. Bremner JD, Staib LH, Kaloupek D, Southwick SM, Soufer R, Charney DS. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biol Psychiatry. 1999;45:806-816.
4. Fernandez M, Pissiota A, Frans O, von Knorring L, Fischer H, Fredrikson M. Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study. Neurosci Lett. 2001;297:101-104.
5. Osuch EA, Benson B, Geraci M, Podell D, Herscovitch P, McCann UD, Post RM. Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder. Biol Psychiatry. 2001;50:246-253.
6. Rauch SL, van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jenike MA, Pitman RK. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry. 1996;53:380-387.
7. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: a PET investigation. Am J Psychiatry. 1999;156:575-584.
8. Lanius RA, Williamson PC, Densmore M, Boksman K, Gupta MA, Neufeld RW, Gati JS, Menon RS. Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation. Am J Psychiatry. 2001;158:1920-1922.
9. Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS. Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry. 1999;156:1787-1795.
10. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000;47:769-776.
11. Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, Orr SP, McInerney SC, Rauch SL. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol Psychiatry. 2001;50:932-942.
12. Rauch SL, Shin LM, Segal E, Pitman RK, Carson MA, McMullin K, Whalen PJ, Makris N. Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport. 2003;14:913-916.
13. De Bellis MD, Keshavan MS, Spencer S, Hall J. N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry. 2000;157:1175-1177.
14. Rauch SL, Shin LM, Whalen PJ, Pitman RK. Neuroimaging and the neuroanatomy of PTSD. CNS Spectr. 1998;3(suppl 2):30-41.
15. Elzinga BM, Bremner JD. Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSO)? J Affect Disord. 2002; 70:1-17.
16. Semple WE, Goyer PF, McCormick R, Donovan B, Muzic RF Jr, Rugle L, McCutcheon K, Lewis C, Liebling D, Kowaliw S, Vapenik K, Semple MA, Flener CR, Schulz SC. Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals. Psychiatry. 2000;63:65-74.
17. Baker RR, Menard SW, Johns LA. The military nurse experiment in Vietnam: stress and impact. J Clin Psychol. 1989;45:736-744.
18. Carson MA, Paulus LA, Lasko NB, Metzger LJ, Wolfe J, Orr SP, Pitman RK. Psychophysiologic assessment of posttraumatic stress disorder in Vietnam nurse veterans who witnessed injury or death. J Consult Clin Psychol. 2000;68:890-897.
19. Gurvits TV, Carson MA, Metzger L, Croteau HB, Lasko NB, Orr SP, Pitman RK. Absence of selected neurological soft signs in Vietnam nurse veterans with posttraumatic stress disorder. Psychiatry Res. 2002;110:81-85.
20. Metzger LJ, Carson MA, Paulus LA, Lasko NB, Paige SR, Pitman RK, Orr SP. Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorder. Psychophysiology. 2002;39:49-63.
21. Pitman RK, Orr SP, Forgue DF, de Jong JB, Claiborn JM. Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans. Arch Gen Psychiatry. 1987;44:970-975.
22. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97-113.
23. Weathers FW, Keane TM, Davidson JR. Clinician-Administered PTSD Scale: a review of the first ten years of research. Depress Anxiety. 2001;13:132-156.
24. Derogatis LR. SCL-90-R: Administration, Scoring, & Procedures Manual-II for the Revised Version. Towson, Md: Clinical Psychometric Research; 1983.
25. First M, Spitzer R, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV. New York: New York State Psychiatric Institute, Biometrics Research Department; 1995.
26. Pitman RK, Orr SP, Forgue DF, Altman B, de Jong JB, Herz LR. Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. J Abnorm Psychol. 1990;99:49-54.
27. Orr SP, Lasko NB, Metzger LJ, Berry NJ, Ahern CE, Pitman RK. Psychophysiologic assessment of women with posttraumatic stress disorder resulting from childhood sexual abuse. J Consult Clin Psychol. 1998;66:906-913.
28. Shin LM, Kosslyn SM, McNally RJ, Alpert NM, Thompson WL, Rauch SL, Macklin ML, Pitman RK. Visual imagery and perception in posttraumatic stress disorder: a positron emission tomographic investigation. Arch Gen Psychiatry. 1997; 54:233-241.
29. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab. 1991; 11:690-699.
30. Zubieta JK, Chinitz JA, Lombardi U, Fig LM, Cameron OG, Liberzon I. Medial frontal cortex involvement in PTSD symptoms: a SPECT study. J Psychiatr Res. 1999; 33:259-264.
31. Lanius R, Williamson P, Boksman K, Densmore M, Gupta M, Neufeld R, Gati J, Menon R. Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatty. 2002;52:305-311.
32. Aggleton JP, Burton MJ, Passingham RE. Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta). Brain Res. 1980;190: 347-368.
33. Chiba T, Kayahara T, Nakano K. Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata. Brain Res. 2001;888:83-101.
34. Stefanacci L, Amaral DG. Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study. J Comp Neurol. 2002;451:301-323.
35. Ghashghaei HT, Barbas H. Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience. 2002;115:1261-1279.
36. Morgan MA, LeDoux JE. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci. 1995;109:681-688.
37. Morgan MA, Romanski LM, LeDoux JE. Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Lett. 1993;163:109-113.
38. Ouirk GJ, Russo GK, Barron JL, Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci. 2000;20:6225-6231.
39. Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002;420:70-74.
40. Garcia R, Vouimba RM, Baudry M, Thompson RF. The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature. 1999;402:294-296.
41. Fredrikson M, Furmark T. Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders. Ann N Y Acad Sci. 2003;985:341-347.