Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety

Psychoneuroendocrinology

Volumn 38, Issue 5, 2013, Pages 694-701

  Weisman, Omri ^a   Zagoory Sharon, Orna ^a   Schneiderman, Inna ^a   Gordon, Ilanit ^a   Feldman, Ruth ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

Anxiety; Attachment; ELISA; Gender; Neuropeptide; Plasma oxytocin; Stress

Indexed keywords

OXYTOCIN;

ANXIETY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; EMOTIONAL ATTACHMENT; FEMALE; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE RESPONSE; HUMAN; MALE; MENTAL STRESS; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; SEX DIFFERENCE; SOCIAL INTERACTION; TREND STUDY;

ADULT; ANXIETY; COHORT STUDIES; FEMALE; HUMANS; MALE; OBJECT ATTACHMENT; OXYTOCIN; SEX CHARACTERISTICS; TEST ANXIETY SCALE; YOUNG ADULT;

EID: 84876073955     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2012.08.011     Document Type: Article

References (48)

1. Aiken L.S., West S.G. Multiple Regression: Testing and Interpreting Interactions 1991, Sage, Thousand Oaks, CA.
2. Amico J.A., Levin S.C., Cameron J.L. Circadian rhythm of oxytocin in the cerebrospinal fluid of rhesus and cynomolgus monkeys: effects of castration and adrenalectomy and presence of a caudal-rostral gradient. Neuroendocrinology 1989, 50:624-632.
3. Atzil S., Hendler T., Feldman R. Specifying the neurobiological basis of human attachment: brain, hormones, and behavior in synchronous and intrusive mothers. Neuropsychopharmacology 2011, 36:2603-2615.
4. Atzil S., Hendler T., Zagoory-Sharon O., Weintbrub Y., Feldman R. Synchrony and specificity in the maternal and the paternal brain: relations to oxytocin and vasopressin. J. Am. Acad. Child Adolesc. Psychiatry 2012, 51:798-811.
5. Bartz J.A., Zaki J., Bolger N., Ochsner K.N. Social effects of oxytocin in humans: context and person matter. Trends Cogn. Sci. 2011, 15:301-309.
6. Brennan K.A., Clark C.L., Shaver P.R. Self-report measurement of adult attachment: an integrative overview. Attachment Theory and Close Relationships 1998, 46-76. Guilford, New York. J.A. Simpson, W.S. Rholes (Eds.).
7. Carter C.S. Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?. Behav. Brain Res. 2007, 176:170-186.
8. Carter C.S., Boone E.M., Pournajafi-Nazarloo H., Bales K.L. Consequences of early experience and exposure to oxytocin and vasopressin are sexually dimorphic. Dev. Neurosci. 2009, 31:332-341.
9. Carter C.S., Pournajafi-Nazarloo H., Kramer K.M., Ziegler T.E., White-Traut R., Bello D., et al. Oxytocin: behavioral associations and potential as a salivary biomarker. Ann. N. Y. Acad. Sci. 2007, 1098:312-322.
10. Churchland P.S., Winkielman P. Modulating social behavior with oxytocin: how does it work? What does it mean?. Horm. Behav. 2012, 61:392-399.
11. Ditzen B., Schaer M., Gabriel B., Bodenmann G., Ehlert U., Heinrichs M. Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry 2009, 65:728-731.
12. Feldman R. Oxytocin and social affiliation in humans. Horm. Behav. 2012, 61:380-391.
13. Feldman R., Gordon I., Zagoory-Sharon O. Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: considering stress and affiliation components of human bonding. Dev. Sci. 2011, 14:752-761.
14. Feldman R., Gordon I., Schneiderman I., Weisman O., Zagoory-Sharon O. Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology 2010, 35:1133-1141.
15. Feldman R., Weller A., Zagoory-Sharon O., Levine A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol. Sci. 2007, 18:965-970.
16. Feldman R., Zagoory-Sharon O., Weisman O., Schneiderman I., Gordon I., et al. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the oxytocin receptor (OXTR) and CD38 genes. Biol. Psychiatry 2012, 72:175-181.
17. Frasure-Smith N., Lesperance F., Talajic M. The impact of negative emotions on prognosis following myocardial infarction: is it more than depression?. Health Psychol. 1995, 14:388-398.
18. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 2001, 81:629-683.
19. Gouin J.P., Carter C.S., Pournajafi-Nazarloo H., Glaser R., Malarkey W.B., et al. Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 2010, 35:1082-1090.
20. Gordon I., Zagoory-Sharon O., Schneiderman I., Leckman J.F., Weller A., Feldman R. Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress. Psychophysiology 2008, 45:349-352.
21. Gordon I., Zagoory-Sharon O., Leckman J.F., Feldman R. Oxytocin and the development of parenting in humans. Biol. Psychiatry 2010, 68:679-684.
22. Grippo A.J., Gerena D., Huang J., Kumar N., Shah M., Ughreja R., et al. Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 2007, 32:966-980.
23. Heinrichs M., Baumgartner T., Kirschbaum C., Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol. Psychiatry 2003, 54:1389-1398.
24. Heinrichs M., von Dawans B., Domes G. Oxytocin, vasopressin, and human social behavior. Front. Neuroendocrinol. 2009, 30:548-557.
25. Kirsch P., Esslinger C., Chen Q., Mier D., Lis S., Siddhanti S., et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. J. Neurosci. 2005, 25:11489-11493.
26. Kiss A., Mikkelsen J.D. Oxytocin - anatomy and functional assignments: a mini review. Endocr. Regul. 2005, 39:97-105.
27. Kramer K.M., Cushing B.S., Carter C.S., Wu J., Ottinger M.A. Sex and species differences in plasma oxytocin using enzyme immunoassay. Can. J. Zool. 2004, 82:1194-1200.
28. Leckman J.F., Feldman R., Swain J.E., Eicher V., Thompson N., Mayes L.C. Primary parental preoccupation: circuits, genes, and the crucial role of the environment. J. Neural. Transm. 2004, 11:753-771.
29. Leckman J.F., Mayes L.C. Preoccupations and behaviors associated with romantic and parental love. Perspectives on the origin of obsessive-compulsive disorder. Child Adolesc. Psychiatr. Clin. N. Am. 1999, 8:635-665.
30. Light K.C., Grewen K.M., Amico J.A. More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women. Biol. Psychology 2005, 69:5-21.
31. Maestripieri D., Hoffman C.L., Anderson G.M., Carter C.S., Higley J.D. Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables. Physiol. Behav. 2009, 96:613-619.
32. Marazitti D., Dell'Osso B., Baroni S., Mungai F., Catena M., Rucci P., Albanese F., Giannaccini G., Betti L., Fabbrini L., Italiani P., Del Debbio A., Lucacchini A., Dell'Osso L. A relationship between oxytocin and anxiety of romantic attachment. Clin. Pract. Epidemiol. Mental Health 2006, 2:28.
33. McCall C., Singer T. The animal and human neuroendocrinology of social cognition, motivation and behavior. Nat. Neurosci. 2012, 15:681-688.
34. Meaney M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 2001, 24:1161-1192.
35. Meyer-Lindenberg A., Domes G., Kirsch P., Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 2012, 12:524-538.
36. Neumann I.D. Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J. Neuroendocrinol. 2008, 20:858-865.
37. Opacka-Juffry J., Mohiyeddini C. Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress 2012, 15:1-10.
38. Oxley G., Fleming A.S. The effects of medial preoptic area and amygdala lesions on maternal behavior in the juvenile rat. Dev. Psychobiol. 2000, 37:253-265.
39. Porges S.W., Carter C.S. Neurobiology and evolution: mechanisms, mediators, and adaptive consequences of caregiving. Self Interest and Beyond: Towards a New Understanding of Human Caregiving 2011, 53-71. Oxford University Press, New York. S.L. Brown, R.M. Brown, L.A. Penner (Eds.).
40. Ross H.E., Young L.J. Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Front. Neuroendocrinol. 2009, 30:534-547.
41. Slattery D.A., Neumann I.D. Oxytocin and major depression disorder: experimental and clinical evidence for etiology and possible treatment. Pharmaceuticals 2010, 3:702-724.
42. Spielberger C.D., Gorsuch R.L., Lushene R.E. STAI Manual for the State-Trait Anxiety Inventory 1970, Consulting Psychological Press, Palo Alto, CA.
43. Strathearn L., Fonagy P., Amico J., Montague P.R. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 2009, 34:2655-2666.
44. Tabak B.A., McCullough M.E., Szeto A., Mendez A.J., McCabe P.M. Oxytocin indexes relational distress following interpersonal harms in women. Psychoneuroendocrinology 2011, 36:115-122.
45. Taylor S.E., Gonzaga G., Klein L.C., Hu P., Greendale G.A., Seeman T.E. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom. Med. 2006, 68:238-245.
46. Taylor S.E., Saphire-Bernstein S., Seeman T.E. Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair bond relationships?. Psychol. Sci. 2010, 21:3-7.
47. Turner R.A., Altemus M., Enos T., Cooper B., McGuinness T. Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. Psychiatry 1999, 62:97-113.
48. Weisman O., Zagoory-Sharon O., Feldman R. Intranasal oxytocin administration is reflected in human saliva. Psychoneuroendocrinology 2012, 37:1582-1586.