Oxytocin Stimulates Extracellular Ca2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert Its Anxiolytic Effects

Neuropsychopharmacology

Volumn 40, Issue 13, 2015, Pages 2938-2947

  Van Den Burg, Erwin H ^a   Stindl, Julia ^b   Grund, Thomas ^a   Neumann, Inga D ^a   Strauss, Olaf ^b,c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXYTOCIN; RNA DIRECTED DNA POLYMERASE; VANILLOID RECEPTOR 2; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; ANXIOLYTIC AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; DIVALENT CATION; IMIDAZOLE DERIVATIVE; OXYTOCIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TRPV2 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; DRUG ANALYSIS; EXTRACELLULAR CALCIUM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; INTRACELLULAR SIGNALING; NERVE CELL; NONHUMAN; OSCILLATION; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; STEREOTACTIC PROCEDURE; TRANQUILIZING ACTIVITY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ANXIETY; CALCIUM SIGNALING; DRUG EFFECTS; DRUG THERAPY; EXTRACELLULAR SPACE; MALE; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; PRECLINICAL STUDY; WISTAR RAT;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CATIONS, DIVALENT; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR SPACE; IMIDAZOLES; MALE; MOTOR ACTIVITY; NEURONS; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PHOSPHATIDYLINOSITOL 3-KINASES; RATS, WISTAR; RECEPTORS, OXYTOCIN; TRPV CATION CHANNELS;

EID: 84947034964     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.147     Document Type: Article

References (37)

1. Bale TL, Davis AM, Auger AP, Dorsa DM, McCarthy MM (2001). CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 21: 2546-2552.
2. Ben-Barak Y, Russell JT, Whitnall MH, Ozato K, Gainer H (1985). Neurophysin in the hypothalamo-neurohypophysial system. I. Production and characterization of monoclonal antibodies. J Neurosci 5: 81-97.
3. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004). Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6: 709-720.
4. Blume A, Bosch OJ, Miklos S, Torner L, Wales L, Waldherr M et al (2008). Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus. Eur J Neurosci 27: 1947-1956.
5. Boels K, Glassmeier G, Herrmann D, Riedel IB, Hampe W, Kojima I et al (2001). The neuropeptide head activator induces activation and translocation of the growth factor-regulated Ca(2+)-permeable channel GRC. J Cell Sci 114: 3599-3606.
6. Bunck M, Czibere L, Horvath C, Graf C, Frank E, Kessler MS et al (2009). A hypomorphic vasopressin allele prevents anxiety-related behavior. PLoS One 4: e5129.
7. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999). A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398: 436-441.
8. Chen S, Lin F, Shin ME, Wang F, Shen L, Hamm HE (2008). RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell 19: 3909-3922.
9. Clapham DE (2007). SnapShot: mammalian TRP channels. Cell 129: 220.
10. Cornell RA, Aarts M, Bautista D, Garcia-Anoveros J, Kiselyov K, Liman ER (2008). A double TRPtych: six views of transient receptor potential channels in disease and health. J Neurosci 28: 11778-17784.
11. Evans CH (1983). Interesting and useful biochemical properties of lanthanides. Trends Biochem Sci 8: 445-449.
12. Everaerts W, Vriens J, Owsianik G, Appendino G, Voets T, De Ridder D et al (2010). Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol 298: F692-F701.
13. Gimpl G, Fahrenholz F (2001). The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81: 629-683.
14. Grynkiewicz G, Poenie M, Tsien RY (1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
15. Guzman YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H et al (2013). Fear-enhancing effects of septal oxytocin receptors. Nat Neurosci 16: 1185-1187.
16. Israel J-M, Poulain DA, Oliet SHR (2008). Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons. J Neurosci 28: 385-394.
17. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O et al (2007). CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446: 41-45.
18. Jurek B, Slattery DA, Maloumby R, Hillerer K, Koszinowski S, Neumann ID et al (2012). Differential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats. PLoS One 7: e37060.
19. Knobloch HS, Charlet A, Hoffmann LC, Eliava M, Khrulev S, Cetin AH et al (2012). Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73: 553-566.
20. Lambert RC, Dayanithi G, Moos FC, Richard P (1994). A rise in the intracellular Ca2+ concentration of isolated rat supraoptic cells in response to oxytocin. J Physiol 478: 275-287.
21. Landgraf R, Kessler MS, Bunck M, Murgatroyd C, Spengler D, Zimbelmann M et al (2007). Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I. Neurosci Biobehav Rev 31: 89-102.
22. Ludwig M, Sabatier N, Bull PM, Landgraf R, Dayanithi G, Leng G (2002). Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites. Nature 418: 85-89.
23. Lukas M, Toth I, Reber SO, Slattery DA, Veenema AH, Neumann ID (2008). The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice. Neuropsychopharmacology 36: 2159-2168.
24. Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F et al (2007). Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 27: 832-839.
25. Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12: 524-538.
26. Mugele K, Kügler H, Spiess J (1993). Immortalization of a fetal rat brain cell line that expresses corticotropin-releasing factor mRNA. DNA Cell Biol 12: 119-126.
27. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M et al (2003). TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93: 829-838.
28. Murgatroyd C, Wigger A, Frank E, Singewald N, Bunck M, Holsboer F et al (2004). Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety. J Neurosci 24: 7762-7770.
29. Nedungadi TP, Dutta M, Bathina CS, Caterina MJ, Cunningham JT (2012). Expression and distribution of TRPV2 in rat brain. Exp Neurol 237: 223-237.
30. Paxinos G, Watson C (1998). The Rat Brain in Sterotaxic Coordinates, 4th edn. Academic Press: New York.
31. Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (2008). TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28: 6231-6238.
32. Ramsey IS, Delling M, Clapham DE (2006). An introduction to TRP channels. Annu Rev Physiol 68: 619-647.
33. Riccio A, Li Y, Moon J, Kim K-S, Smith KS, Rudolph U et al (2009). Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137: 761-772.
34. Sabatier N, Richard P, Dayanithi G (1997). L-, N- and T- but neither P- nor Q-type Ca2+ channels control vasopressin-induced Ca2+ influx in magnocellular vasopressin neurones isolated from the rat supraoptic nucleus. J Physiol 503: 253-268.
35. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M (2010). TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci 30: 4601-4612.
36. Tasker JG, Dudek FE (1991). Electrophysiological properties of neurones in the region of the paraventricular nucleus in slices of rat hypothalamus. J Physiol 434: 271-293.
37. Wainwright A, Rutter AR, Seabrook GR, Reilly K, Oliver KR (2004). Discrete expression of TRPV2 within the hypothalamoneurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. J Comp Neurol 474: 24-42.