The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention

Psychoneuroendocrinology

Volumn 36, Issue 8, 2011, Pages 1249-1256

  Holt Lunstad, Julianne ^a   Birmingham, Wendy ^b   Light, Kathleen C ^b  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Couples; Depression; Oxytocin; Stress

Indexed keywords

OXYTOCIN;

ADULT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; OXYTOCIN BLOOD LEVEL; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; SALIVA LEVEL; SELF REPORT; SEX DIFFERENCE; SOCIAL SUPPORT; SYMPTOMATOLOGY; WARM TOUCH;

ADULT; DEPRESSION; FAMILY CHARACTERISTICS; FEMALE; HUMANS; MALE; MONITORING, PHYSIOLOGIC; OXYTOCIN; PERCEPTION; PSYCHOTHERAPY; SALIVA; STRESS, PSYCHOLOGICAL; TIME FACTORS; TOUCH; YOUNG ADULT;

EID: 79961239714     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2011.03.007     Document Type: Article

References (56)

1. Amico J.A., Mantella R.C., Vollmer R.R., Li X. Anxiety and stress responses in female oxytocin deficient mice. J. Neuroendocrinol. 2004, 16(4):319-324. doi:10.1111/j.0953-8194.2004.01161.x. JNE1161 [pii].
2. Carter C.S. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 1998, 23(8):779-818. doi:S0306453098000559 [pii].
3. Carter C.S., Pournajafi-Nazarloo H., Kramer K.M., Ziegler T.E., White-Traut R., Bello D., et al. Oxytocin: behavioral associations and potential as a salivary biomarker. Ann. N Y Acad. Sci. 2007, 1098:312-322. doi:1098/1/312 [pii] 10.1196/annals.1384.006.
4. Cohen C.I., Goh K.H., Gustave M. A prospective study of outcome and predictors of subclinical and clinical depression in an older biracial sample of psychiatric outpatients. J. Affect. Disord. 2010, 121(3):204-211. doi:S0165-0327(09)00231-6 [pii] 10.1016/j.jad.2009.05.021.
5. Cohen S., Kamarck T., Mermelstein R. A global measure of perceived stress. J. Health Soc. Behav. 1983, 24(4):385-396.
6. Cyranowski J.M., Hofkens T.L., Frank E., Seltman H., Cai H.M., Amico J.A. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom. Med. 2008, 70(9):967-975. doi:70/9/967 [pii] 10.1097/PSY.0b013e318188ade4.
7. Davey H.L., Tough S.C., Adair C.E., Benzies K.M. Risk factors for sub-clinical and major postpartum depression among a community cohort of Canadian women. Matern. Child. Health J. 2008, doi:10.1007/s10995-008-0314-8.
8. Dickerson S.S., Kemeny M.E. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bull. 2004, 130(3):355-391.
9. Gordon I., Zagoory-Sharon O., Schneiderman I., Leckman J.F., Weller A., Feldman R. Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress. Psychophysiology 2008, 45(3):349-352. doi: PSYP649 [pii] 10.1111/j.1469-8986.2008.00649.x.
10. Garcia F.D., Coquerel Q., Kiive E., Dechelotte P., Harro J., Fettisov S.O. Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression. Prog. NeuroPsychopharmacol. Biol. Psychiatry 2010.
11. Grewen K.M., Davenport R.E., Light K.C. An investigation of plasma and salivary oxytocin responses in breast- and formula-feeding mothers of infants. Psychophysiology 2010, 47(4):625-632. Epub 2010 Jan 22.PMID: 20102537.
12. Grewen K.M., Girdler S.S., Amico J., Light K.C. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom. Med. 2005, 67(4):531-538. doi:67/4/531 [pii] 10.1097/01.psy.0000170341.88395.47.
13. Grewen, K.M., Light, K.C., submitted for publication. Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress. Biological Psychology.
14. Grigoriadis S., Robinson G.E. Gender issues in depression. Ann. Clin. Psychiatry 2007, 19(4):247-255. doi:787699661 [pii] 10.1080/10401230701653294.
15. Grippo A.J., Gerena D., Huang J., Kumar N., Shah M., Ughreja R., et al. Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 2007, 32(8-10):966-980. doi:S0306-4530(07)00167-9 [pii] 10.1016/j.psyneuen.2007.07.004.
16. Grippo A.J., Johnson A.K. Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 2009, 12(1):1-21. doi:907251419 [pii] 10.1080/10253890802046281.
17. Grippo A.J., Trahanas D.M., Zimmerman R.R., Porges S.W., Carter C.S. Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation. Psychoneuroendocrinology 2009, 34(10):1542-1553. doi:S0306-4530(09)00178-4 [pii] 10.1016/j.psyneuen.2009.05.017.
18. Guastella A.J., Howard A.L., Dadds M.R., Mitchell P., Carson D.S. A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 2009, 34(6):917-923. doi:S0306-4530(09)00023-7 [pii] 10.1016/j.psyneuen.2009.01.005.
19. Hoge E.A., Pollack M.H., Kaufman R.E., Zak P.J., Simon N.M. Oxytocin levels in social anxiety disorder. CNS Neurosci. Ther. 2008, 14(3):165-170. doi:CNS051 [pii] 10.1111/j.1755-5949.2008.00051.x.
20. Holt-Lunstad J., Birmingham W.A., Light K.C. Influence of a "warm touch" support enhancement intervention among married couples on ambulatory blood pressure, oxytocin, alpha amylase, and cortisol. Psychosom. Med. 2008, 70(9):976-985. doi:PSY.0b013e318187aef7 [pii] 10.1097/PSY.0b013e318187aef7.
21. Hughes S., Cohen D. A systematic review of long-term studies of drug treated and non-drug treated depression. J. Affect. Disord. 2009, 118(1-3):9-18. doi:S0165-0327(09)00049-4 [pii] 10.1016/j.jad.2009.01.027.
22. Kenny D., Kashy D., Cook W. Dyadic Data Analysis 2006, Guilford, New York.
23. Keri S., Kiss I. Oxytocin response in a trust game and habituation of arousal. Physiol. Behav. 2011, 102:221-224. doi:10.1016/j.physbeh.2010.11.011.
24. Klein L.C., Corwin E.J. Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Curr. Psychiatry Rep. 2002, 4(6):441-448.
25. Legros J.J., Chiodera P., Demey-Ponsart E. Inhibitory influence of exogenous oxytocin on adrenocorticotropin secretion in normal human subjects. J. Clin. Endocrinol. Metab. 1982, 55(6):1035-1039.
26. Light, K.C., White, A., Grewen, K.M., Holt-Lunstad, J., Lawson, M., & Light A., 2010. New markers of oxytocin activity: saliva and leukocyte gene expression. Presented at the Academy of Behavioral Medicine Research.
27. Light K.C., Grewen K.M., Amico J.A. More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women. Biol. Psychol. 2005, 69(1):5-21. doi:S0301-0511(04)00163-2 [pii] 10.1016/j.biopsycho.2004.11.002.
28. Light K.C., Smith T.E., Johns J.M., Brownley K.A., Hofheimer J.A., Amico J.A. Oxytocin responsivity in mothers of infants: a preliminary study of relationships with blood pressure during laboratory stress and normal ambulatory activity. Health Psychol. 2000, 19:560-567.
29. Little R.C., Milliken G.A., Stroup W.W., Wolfinger R.D. SAS System for Mixed Models 1996, SAS Institute Inc, Cary, NC.
30. Marazziti D., Dell'Osso B., Baroni S., Mungai F., Catena M., Rucci P., et al. A relationship between oxytocin and anxiety of romantic attachment. Clin. Pract. Epidemiol. Ment. Health 2006, 2:28. doi:1745-0179-2-28 [pii] 10.1186/1745-0179-2-28.
31. Matsushita H., Tomizawa K., Okimoto N., Nishiki T., Ohmori I., Matsui H. Oxytocin mediates the antidepressant effects of mating behavior in male mice. Neurosci Res. 2010, doi:S0168-0102(10)00164-1 [pii] 10.1016/j.neures.2010.06.007.
32. McCarthy M.M. Estrogen modulation of oxytocin and its relation to behavior. Adv. Exp. Med. Biol. 1995, 395:235-245.
33. McCormick C.M., Robarts D., Kopeikina K., Kelsey J.E. Long-lasting, sex- and age-specific effects of social stressors on corticosterone responses to restraint and on locomotor responses to psychostimulants in rats. Horm. Behav. 2005, 48(1):64-74. doi:S0018-506X(05)00033-4 [pii] 10.1016/j.yhbeh.2005.01.008.
34. Mosovich S.A., Boone R.T., Reichenberg A., Bansilal S., Shaffer J., Dahlman K., et al. New insights into the link between cardiovascular disease and depression. Int. J. Clin. Pract. 2008, 62(3):423-432. doi:IJCP1640 [pii] 10.1111/j.1742-1241.2007.01640.x.
35. Ozsoy S., Esel E., Kula M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res. 2009, 169(3):249-252. doi:S0165-1781(08)00202-3 [pii] 10.1016/j.psychres.2008.06.034.
36. Parker K.J., Kenna H.A., Zeitzer J.M., Keller J., Blasey C.M., Amico J.A., et al. Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Res. 2010, doi:S0165-1781(09)00362-X [pii] 10.1016/j.psychres.2009.09.017.
37. Radloff L.S. The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1977, 1(3):385-401.
38. Ring R.H., Malberg J.E., Potestio L., Ping J., Boikess S., Luo B., et al. Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications. Psychopharmacology (Berl) 2006, 185(2):218-225. doi:10.1007/s00213-005-0293-z.
39. Rotzinger S., Lovejoy D.A., Tan L.A. Behavioral effects of neuropeptides in rodent models of depression and anxiety. Peptides 2010, 31(4):736-756. doi:S0196-9781(09)00535-X [pii] 10.1016/j.peptides.2009.12.015.
40. Scantamburlo G., Ansseau M., Geenen V., Legros J.J. Oxytocin: from milk ejection to maladaptation in stress response and psychiatric disorders. A psychoneuroendocrine perspective. Ann. Endocrinol. (Paris) 2009, 70(6):449-454. doi:S0003-4266(09)00264-9 [pii] 10.1016/j.ando.2009.09.002.
41. Scantamburlo G., Hansenne M., Fuchs S., Pitchot W., Marechal P., Pequeux C., et al. Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology 2007, 32(4):407-410. doi:S0306-4530(07)00029-7 [pii] 10.1016/j.psyneuen.2007.01.009.
42. Seldenrijk A., Vogelzangs N., van Hout H.P., van Marwijk H.W., Diamant M., Penninx B.W. Depressive and anxiety disorders and risk of subclinical atherosclerosis Findings from the Netherlands Study of Depression and Anxiety (NESDA). J. Psychosom. Res. 2010, 69(2):203-210. doi:S0022-3999(10)00010-3 [pii] 10.1016/j.jpsychores.2010.01.005.
43. Singer J.D. Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J. Educ. Behav. Stat. 1998, 23:323-355.
44. Slattery D.A., Neumann I.D. Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats. Neuropharmacology 2010, 58(1):56-61. doi:S0028-3908(09)00202-0 [pii] 10.1016/j.neuropharm.2009.06.038.
45. Spitzer C., Volzke H., Barnow S., Krohn U., Wallaschofski H., Ludemann J., et al. Association between depression and subclinical carotid atherosclerosis in patients with Type 1 diabetes. Diab. Med. 2008, 25(3):349-354. doi:DME2369 [pii] 10.1111/j.1464-5491.2007.02369.x.
46. Taylor S.E., Gonzaga G.C., Klein L.C., Hu P., Greendale G.A., Seeman T.E. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom. Med. 2006, 68(2):238-245. doi:68/2/238 [pii] 10.1097/01.psy.0000203242.95990.74.
47. Taylor S.E., Saphire-Bernstein S., Seeman T.E. Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair-bond relationships?. Psychol. Sci. 2010, 21(1):3-7. doi:0956797609356507 [pii] 10.1177/0956797609356507.
48. Tops M., van Peer J.M., Korf J. Individual differences in emotional expressivity predict oxytocin responses to cortisol administration: relevance to breast cancer?. Biol. Psychol. 2007, 75(2):119-123. doi:S0301-0511(07)00004-X [pii] 10.1016/j.biopsycho.2007.01.001.
49. Tops M., van Peer J.M., Korf J., Wijers A.A., Tucker D.M. Anxiety, cortisol, and attachment predict plasma oxytocin. Psychophysiology 2007, 44(3):444-449. doi:PSYP510 [pii] 10.1111/j.1469-8986.2007.00510.x.
50. Turner R.A., Altemus M., Enos T., Cooper B., McGuinness T. Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. Psychiatry 1999, 62(2):97-113.
51. Van der Kooy K., van Hout H., Marwijk H., Marten H., Stehouwer C., Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int. J. Geriatr. Psychiatry 2007, 22(7):613-626. doi:10.1002/gps.1723.
52. Viviani D., Terrettaz T., Magara F., Stoop R. Oxytocin enhances the inhibitory effects of diazepam in the rat central medial amygdala. Neuropharmacology 2010, 58(1):62-68. doi:S0028-3908(09)00203-2 [pii] 10.1016/j.neuropharm.2009.06.039.
53. Waldherr M., Neumann I.D. Centrally released oxytocin mediates mating-induced anxiolysis in male rats. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(42):16681-16684. doi:0705860104 [pii] 10.1073/pnas.0705860104.
54. Windle R.J., Kershaw Y.M., Shanks N., Wood S.A., Lightman S.L., Ingram C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J. Neurosci. 2004, 24(12):2974-2982. doi:10.1523/JNEUROSCI. 3432-03.2004. 24/12/2974 [pii].
55. Yoshida M., Takayanagi Y., Inoue K., Kimura T., Young L.J., Onaka T., et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J. Neurosci. 2009, 29(7):2259-2271. doi:29/7/2259 [pii] 10.1523/JNEUROSCI. 5593-08.2009.
56. Young L.J., Wang Z. The neurobiology of pair bonding. Nat. Neurosci. 2004, 7(10):1048-1054. doi:10.1038/nn1327 [1327nn] [pii].