메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; OXYSTEROL;

EID: 84955472393     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19694     Document Type: Article
Times cited : (49)

References (59)
  • 1
    • 80052255459 scopus 로고    scopus 로고
    • Changing the future of obesity: Science, policy, and action
    • Gortmaker, S. L. et al. Changing the future of obesity: science, policy, and action. Lancet 378, 838-847 (2011).
    • (2011) Lancet , vol.378 , pp. 838-847
    • Gortmaker, S.L.1
  • 2
    • 84885836244 scopus 로고    scopus 로고
    • The disproportionate economic burden associated with severe and complicated obesity: A systematic review
    • Grieve, E., Fenwick, E., Yang, H. C. & Lean, M. The disproportionate economic burden associated with severe and complicated obesity: a systematic review. Obes. Rev. 14, 883-894 (2013).
    • (2013) Obes. Rev. , vol.14 , pp. 883-894
    • Grieve, E.1    Fenwick, E.2    Yang, H.C.3    Lean, M.4
  • 3
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
    • Guh, D. P. et al. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC. Public Health 9, 88 (2009).
    • (2009) BMC. Public Health , vol.9 , pp. 88
    • Guh, D.P.1
  • 4
    • 34248393099 scopus 로고    scopus 로고
    • High-fat diets: Modeling the metabolic disorders of human obesity in rodents
    • Buettner, R., Scholmerich, J. & Bollheimer, L. C. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity. (Silver. Spring) 15, 798-808 (2007).
    • (2007) Obesity. (Silver. Spring) , vol.15 , pp. 798-808
    • Buettner, R.1    Scholmerich, J.2    Bollheimer, L.C.3
  • 5
    • 77952498910 scopus 로고    scopus 로고
    • A mouse model of metabolic syndrome: Insulin resistance, fatty liver and non-alcoholic fatty pancreas disease (NAFPD) in C57BL/6 mice fed a high fat diet
    • Fraulob, J. C., Ogg-Diamantino, R., Fernandes-Santos, C., Aguila, M. B. & Mandarim-de-Lacerda, C. A. A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet. J. Clin. Biochem. Nutr. 46, 212-223 (2010).
    • (2010) J. Clin. Biochem. Nutr. , vol.46 , pp. 212-223
    • Fraulob, J.C.1    Ogg-Diamantino, R.2    Fernandes-Santos, C.3    Aguila, M.B.4    Mandarim-De-Lacerda, C.A.5
  • 6
    • 76049091112 scopus 로고    scopus 로고
    • Lipid homeostasis, lipotoxicity and the metabolic syndrome
    • Unger, R. H., Clark, G. O., Scherer, P. E. & Orci, L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim. Biophys. Acta 1801, 209-214 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 209-214
    • Unger, R.H.1    Clark, G.O.2    Scherer, P.E.3    Orci, L.4
  • 7
    • 80052724732 scopus 로고    scopus 로고
    • Patterns of cholesterol metabolism: Pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome
    • Lupattelli, G., De, V. S. & Mannarino, E. Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome. Nutr. Metab Cardiovasc. Dis. 21, 620-627 (2011).
    • (2011) Nutr. Metab Cardiovasc. Dis. , vol.21 , pp. 620-627
    • Lupattelli, G.1    De, V.S.2    Mannarino, E.3
  • 8
    • 84879132692 scopus 로고    scopus 로고
    • Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome
    • Van Rooyen, D. M. et al. Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome. J. Hepatol. 59, 144-152 (2013).
    • (2013) J. Hepatol. , vol.59 , pp. 144-152
    • Van Rooyen, D.M.1
  • 9
    • 84877791517 scopus 로고    scopus 로고
    • Guidelines updates in the treatment of obesity or metabolic syndrome and hypertension
    • Cerezo, C., Segura, J., Praga, M. & Ruilope, L. M. Guidelines updates in the treatment of obesity or metabolic syndrome and hypertension. Curr. Hypertens. Rep. 15, 196-203 (2013).
    • (2013) Curr. Hypertens. Rep. , vol.15 , pp. 196-203
    • Cerezo, C.1    Segura, J.2    Praga, M.3    Ruilope, L.M.4
  • 10
    • 34848860474 scopus 로고    scopus 로고
    • Implications of the obesity epidemic for statin therapy: Shifting cholesterol metabolism to a high synthesis and low dietary absorption state
    • Hoenig, M. R., Kostner, K. M., Read, S. J., Walker, P. J. & Atherton, J. J. Implications of the obesity epidemic for statin therapy: shifting cholesterol metabolism to a high synthesis and low dietary absorption state. Endocr. Metab Immune. Disord. Drug Targets. 7, 153-166 (2007).
    • (2007) Endocr. Metab Immune. Disord. Drug Targets. , vol.7 , pp. 153-166
    • Hoenig, M.R.1    Kostner, K.M.2    Read, S.J.3    Walker, P.J.4    Atherton, J.J.5
  • 11
    • 80053926900 scopus 로고    scopus 로고
    • New insights into the mechanism of low high-density lipoprotein cholesterol in obesity
    • Wang, H. & Peng, D. Q. New insights into the mechanism of low high-density lipoprotein cholesterol in obesity. Lipids Health Dis. 10, 176 (2011).
    • (2011) Lipids Health Dis. , vol.10 , pp. 176
    • Wang, H.1    Peng, D.Q.2
  • 12
    • 0036903407 scopus 로고    scopus 로고
    • Oxidized products of cholesterol: Dietary and metabolic origin, and proatherosclerotic effects (review)
    • Leonarduzzi, G., Sottero, B. & Poli, G. Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review). J. Nutr. Biochem. 13, 700-710 (2002).
    • (2002) J. Nutr. Biochem. , vol.13 , pp. 700-710
    • Leonarduzzi, G.1    Sottero, B.2    Poli, G.3
  • 13
    • 0032890337 scopus 로고    scopus 로고
    • Oxysterols and atherosclerosis
    • Brown, A. J. & Jessup, W. Oxysterols and atherosclerosis. Atherosclerosis 142, 1-28 (1999).
    • (1999) Atherosclerosis , vol.142 , pp. 1-28
    • Brown, A.J.1    Jessup, W.2
  • 14
    • 47049112744 scopus 로고    scopus 로고
    • Cholesterol, reactive oxygen species, and the formation of biologically active mediators
    • Murphy, R. C. & Johnson, K. M. Cholesterol, reactive oxygen species, and the formation of biologically active mediators. J. Biol. Chem. 283, 15521-15525 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 15521-15525
    • Murphy, R.C.1    Johnson, K.M.2
  • 15
    • 84858703061 scopus 로고    scopus 로고
    • Lipid rafts: A signalling platform linking lipoprotein metabolism to atherogenesis
    • Lemaire-Ewing, S., Lagrost, L. & Neel, D. Lipid rafts: a signalling platform linking lipoprotein metabolism to atherogenesis. Atherosclerosis 221, 303-310 (2012).
    • (2012) Atherosclerosis , vol.221 , pp. 303-310
    • Lemaire-Ewing, S.1    Lagrost, L.2    Neel, D.3
  • 17
    • 67349159434 scopus 로고    scopus 로고
    • Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
    • Vejux, A. & Lizard, G. Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Mol. Aspects Med. 30, 153-170 (2009).
    • (2009) Mol. Aspects Med. , vol.30 , pp. 153-170
    • Vejux, A.1    Lizard, G.2
  • 18
    • 63249096864 scopus 로고    scopus 로고
    • Oxysterols and mechanisms of apoptotic signaling: Implications in the pathology of degenerative diseases
    • Lordan, S., Mackrill, J. J. & O'Brien, N. M. Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases. J. Nutr. Biochem. 20, 321-336 (2009).
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 321-336
    • Lordan, S.1    Mackrill, J.J.2    O'Brien, N.M.3
  • 19
    • 34548231638 scopus 로고    scopus 로고
    • Oxysterols, cholesterol homeostasis, and Alzheimer disease
    • Vaya, J. & Schipper, H. M. Oxysterols, cholesterol homeostasis, and Alzheimer disease. J. Neurochem. 102, 1727-1737 (2007).
    • (2007) J. Neurochem. , vol.102 , pp. 1727-1737
    • Vaya, J.1    Schipper, H.M.2
  • 20
    • 84862687669 scopus 로고    scopus 로고
    • Liver X receptor biology and pharmacology: New pathways, challenges and opportunities
    • Jakobsson, T., Treuter, E., Gustafsson, J. A. & Steffensen, K. R. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol. Sci. 33, 394-404 (2012).
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 394-404
    • Jakobsson, T.1    Treuter, E.2    Gustafsson, J.A.3    Steffensen, K.R.4
  • 21
    • 67349215164 scopus 로고    scopus 로고
    • Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages
    • Torocsik, D., Szanto, A. & Nagy, L. Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages. Mol. Aspects Med. 30, 134-152 (2009).
    • (2009) Mol. Aspects Med. , vol.30 , pp. 134-152
    • Torocsik, D.1    Szanto, A.2    Nagy, L.3
  • 22
    • 0036736781 scopus 로고    scopus 로고
    • Do oxysterols control cholesterol homeostasis?
    • Bjorkhem, I. Do oxysterols control cholesterol homeostasis? J. Clin. Invest 110, 725-730 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 725-730
    • Bjorkhem, I.1
  • 23
    • 84883644250 scopus 로고    scopus 로고
    • Lipokines and oxysterols: Novel adipose-derived lipid hormones linking adipose dysfunction and insulin resistance
    • Murdolo, G. et al. Lipokines and oxysterols: novel adipose-derived lipid hormones linking adipose dysfunction and insulin resistance. Free Radic. Biol. Med. 65, 811-820 (2013).
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 811-820
    • Murdolo, G.1
  • 24
    • 84894797629 scopus 로고    scopus 로고
    • The influence of an obesogenic diet on oxysterol metabolism in C57BL/6J mice
    • Wooten, J. S. et al. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice. Cholesterol. 2014, 843468 (2014).
    • (2014) Cholesterol , vol.2014 , pp. 843468
    • Wooten, J.S.1
  • 25
    • 84923046255 scopus 로고    scopus 로고
    • Cholesterol, inflammation and innate immunity
    • Tall, A. R. & Yvan-Charvet, L. Cholesterol, inflammation and innate immunity. Nat. Rev. Immunol. 15, 104-116 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 104-116
    • Tall, A.R.1    Yvan-Charvet, L.2
  • 26
    • 84869050741 scopus 로고    scopus 로고
    • Central nervous system control of metabolism
    • Myers, M. G., Jr. & Olson, D. P. Central nervous system control of metabolism. Nature 491, 357-363 (2012).
    • (2012) Nature , vol.491 , pp. 357-363
    • Myers, M.G.1    Olson, D.P.2
  • 27
    • 79960932903 scopus 로고    scopus 로고
    • Hypothalamic control of lipid metabolism: Focus on leptin, ghrelin and melanocortins
    • Dieguez, C., Vazquez, M. J., Romero, A., Lopez, M. & Nogueiras, R. Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins. Neuroendocrinology 94, 1-11 (2011).
    • (2011) Neuroendocrinology , vol.94 , pp. 1-11
    • Dieguez, C.1    Vazquez, M.J.2    Romero, A.3    Lopez, M.4    Nogueiras, R.5
  • 28
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 110, 9066-9071 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 9066-9071
    • Everard, A.1
  • 29
    • 84860322835 scopus 로고    scopus 로고
    • Genomic analysis of reactive astrogliosis
    • Zamanian, J. L. et al. Genomic analysis of reactive astrogliosis. J. Neurosci. 32, 6391-6410 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 6391-6410
    • Zamanian, J.L.1
  • 31
    • 84955516111 scopus 로고    scopus 로고
    • Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols
    • In Press
    • Mutemberezi, V., Masquelier, J., Guillemot-Legris, O. & Muccioli, G. G. Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols. Anal Bioanal. Chem. In Press (2015) doi:10.1007/s00216-015-9150-z.
    • (2015) Anal Bioanal. Chem.
    • Mutemberezi, V.1    Masquelier, J.2    Guillemot-Legris, O.3    Muccioli, G.G.4
  • 32
    • 84898787487 scopus 로고    scopus 로고
    • Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse
    • Meljon, A., Wang, Y. & Griffiths, W. J. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. Biochem. Biophys. Res. Commun. 446, 768-774 (2014).
    • (2014) Biochem. Biophys. Res. Commun. , vol.446 , pp. 768-774
    • Meljon, A.1    Wang, Y.2    Griffiths, W.J.3
  • 33
    • 0033594903 scopus 로고    scopus 로고
    • CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund, E. G., Guileyardo, J. M. & Russell, D. W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. USA 96, 7238-7243 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7238-7243
    • Lund, E.G.1    Guileyardo, J.M.2    Russell, D.W.3
  • 34
    • 0034595650 scopus 로고    scopus 로고
    • Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
    • Li-Hawkins, J., Lund, E. G., Bronson, A. D. & Russell, D. W. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J. Biol. Chem. 275, 16543-16549 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 16543-16549
    • Li-Hawkins, J.1    Lund, E.G.2    Bronson, A.D.3    Russell, D.W.4
  • 35
    • 14644420874 scopus 로고    scopus 로고
    • Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis
    • Mast, N. et al. Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis. Biochemistry 44, 3259-3271 (2005).
    • (2005) Biochemistry , vol.44 , pp. 3259-3271
    • Mast, N.1
  • 36
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell, D. W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72, 137-174 (2003).
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 37
    • 46449138900 scopus 로고    scopus 로고
    • Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening
    • McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. Drug Metab Dispos. 36, 1322-1331 (2008).
    • (2008) Drug Metab Dispos. , vol.36 , pp. 1322-1331
    • McLaughlin, L.A.1    Dickmann, L.J.2    Wolf, C.R.3    Henderson, C.J.4
  • 38
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
    • Nelson, D. R. et al. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14, 1-18 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 1-18
    • Nelson, D.R.1
  • 39
  • 40
    • 84887378064 scopus 로고    scopus 로고
    • SULT2B1: Unique properties and characteristics of a hydroxysteroid sulfotransferase family
    • Falany, C. N. & Rohn-Glowacki, K. J. SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family. Drug Metab Rev. 45, 388-400 (2013).
    • (2013) Drug Metab Rev. , vol.45 , pp. 388-400
    • Falany, C.N.1    Rohn-Glowacki, K.J.2
  • 41
    • 46949102623 scopus 로고    scopus 로고
    • Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients
    • Bertolotti, M. et al. Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients. Steroids 73, 1197-1202 (2008).
    • (2008) Steroids , vol.73 , pp. 1197-1202
    • Bertolotti, M.1
  • 42
    • 0142074212 scopus 로고    scopus 로고
    • Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood
    • Galman, C., Arvidsson, I., Angelin, B. & Rudling, M. Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. J. Lipid Res. 44, 859-866 (2003).
    • (2003) J. Lipid Res. , vol.44 , pp. 859-866
    • Galman, C.1    Arvidsson, I.2    Angelin, B.3    Rudling, M.4
  • 43
    • 80051471752 scopus 로고    scopus 로고
    • Pathways of cholesterol oxidation via non-enzymatic mechanisms
    • Iuliano, L. Pathways of cholesterol oxidation via non-enzymatic mechanisms. Chem. Phys. Lipids 164, 457-468 (2011).
    • (2011) Chem. Phys. Lipids , vol.164 , pp. 457-468
    • Iuliano, L.1
  • 44
    • 84876917874 scopus 로고    scopus 로고
    • Consumption of a high-fat diet during pregnancy changes the expression of cytochrome P450 in the livers of infant male mice
    • Tajima, M. et al. Consumption of a high-fat diet during pregnancy changes the expression of cytochrome P450 in the livers of infant male mice. Biol. Pharm. Bull. 36, 649-657 (2013).
    • (2013) Biol. Pharm. Bull. , vol.36 , pp. 649-657
    • Tajima, M.1
  • 45
    • 84893101327 scopus 로고    scopus 로고
    • Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis
    • Kusunoki, Y. et al. Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis. Eur. J. Pharm. Sci. 54, 17-27 (2014).
    • (2014) Eur. J. Pharm. Sci. , vol.54 , pp. 17-27
    • Kusunoki, Y.1
  • 46
    • 23744498856 scopus 로고    scopus 로고
    • Crossing the barrier: Net flux of 27-hydroxycholesterol into the human brain
    • Heverin, M. et al. Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J. Lipid Res. 46, 1047-1052 (2005).
    • (2005) J. Lipid Res. , vol.46 , pp. 1047-1052
    • Heverin, M.1
  • 47
    • 0037377403 scopus 로고    scopus 로고
    • Bile acid regulation of hepatic physiology: III. Regulation of bile acid synthesis: Past progress and future challenges
    • Fuchs, M. Bile acid regulation of hepatic physiology: III. Regulation of bile acid synthesis: past progress and future challenges. Am. J. Physiol Gastrointest. Liver Physiol 284, G551-G557 (2003).
    • (2003) Am. J. Physiol Gastrointest. Liver Physiol , vol.284 , pp. G551-G557
    • Fuchs, M.1
  • 49
    • 84871242500 scopus 로고    scopus 로고
    • Bile acid transporters and regulatory nuclear receptors in the liver and beyond
    • Halilbasic, E., Claudel, T. & Trauner, M. Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J. Hepatol. 58, 155-168 (2013).
    • (2013) J. Hepatol. , vol.58 , pp. 155-168
    • Halilbasic, E.1    Claudel, T.2    Trauner, M.3
  • 50
    • 84937414282 scopus 로고    scopus 로고
    • Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human
    • Tremblay-Franco, M. et al. Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human. Steroids 99, 287-292 (2015).
    • (2015) Steroids , vol.99 , pp. 287-292
    • Tremblay-Franco, M.1
  • 51
    • 78149496368 scopus 로고    scopus 로고
    • Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases
    • Faulds, M. H., Zhao, C. & Dahlman-Wright, K. Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases. Curr. Opin. Pharmacol. 10, 692-697 (2010).
    • (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 692-697
    • Faulds, M.H.1    Zhao, C.2    Dahlman-Wright, K.3
  • 52
    • 46149098344 scopus 로고    scopus 로고
    • LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    • Bensinger, S. J. et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134, 97-111 (2008).
    • (2008) Cell , vol.134 , pp. 97-111
    • Bensinger, S.J.1
  • 53
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer, N. & Tontonoz, P. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest 116, 607-614 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 54
    • 84867427020 scopus 로고    scopus 로고
    • Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)
    • Benned-Jensen, T. et al. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J. Biol. Chem. 287, 35470-35483 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 35470-35483
    • Benned-Jensen, T.1
  • 56
    • 84895801586 scopus 로고    scopus 로고
    • REV-ERB and ROR nuclear receptors as drug targets
    • Kojetin, D. J. & Burris, T. P. REV-ERB and ROR nuclear receptors as drug targets. Nat. Rev. Drug Discov. 13, 197-216 (2014).
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 197-216
    • Kojetin, D.J.1    Burris, T.P.2
  • 57
    • 77953243855 scopus 로고    scopus 로고
    • A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)
    • Wang, Y., Kumar, N., Crumbley, C., Griffin, P. R. & Burris, T. P. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim. Biophys. Acta 1801, 917-923 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 917-923
    • Wang, Y.1    Kumar, N.2    Crumbley, C.3    Griffin, P.R.4    Burris, T.P.5
  • 58
    • 84886389627 scopus 로고    scopus 로고
    • Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6
    • Alhouayek, M., Masquelier, J., Cani, P. D., Lambert, D. M. & Muccioli, G. G. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc. Natl. Acad. Sci. USA 110, 17558-17563 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 17558-17563
    • Alhouayek, M.1    Masquelier, J.2    Cani, P.D.3    Lambert, D.M.4    Muccioli, G.G.5
  • 59
    • 84924667080 scopus 로고    scopus 로고
    • Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
    • Geurts, L. et al. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nat. Commun. 6, 6495 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6495
    • Geurts, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.