-
1
-
-
0032892176
-
Removal of cholesterol from extrahepatic sources by oxidative mechanisms
-
I. Björkhem, U. Diczfalusy, and D. Lütjohann Removal of cholesterol from extrahepatic sources by oxidative mechanisms Curr. Opin. Lipidol. 10 1999 161 165
-
(1999)
Curr. Opin. Lipidol.
, vol.10
, pp. 161-165
-
-
Björkhem, I.1
Diczfalusy, U.2
Lütjohann, D.3
-
2
-
-
0037790917
-
The enzymes, regulation, and genetics of bile acid synthesis
-
D.W. Russell The enzymes, regulation, and genetics of bile acid synthesis Annu. Rev. Biochem. 72 2003 137 174
-
(2003)
Annu. Rev. Biochem.
, vol.72
, pp. 137-174
-
-
Russell, D.W.1
-
3
-
-
0035813114
-
From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
-
I. Björkhem, U. Andersson, E. Ellis, G. Alvelius, L. Ellegard, U. Diczfalusy, J. Sjövall, and C. Einarsson From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans J. Biol. Chem. 276 2001 37004 37010
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37004-37010
-
-
Björkhem, I.1
Andersson, U.2
Ellis, E.3
Alvelius, G.4
Ellegard, L.5
Diczfalusy, U.6
Sjövall, J.7
Einarsson, C.8
-
4
-
-
0033594903
-
CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
-
E.G. Lund, J.M. Guileyardo, and D.W. Russell CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain Proc. Natl. Acad. Sci. USA 96 1999 7238 7243
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7238-7243
-
-
Lund, E.G.1
Guileyardo, J.M.2
Russell, D.W.3
-
5
-
-
0035856407
-
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
-
N. Bogdanovic, L. Bretillon, E.G. Lund, U. Diczfalusy, L. Lannfelt, B. Winblad, D.W. Russell, and I. Björkhem On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells Neurosci. Lett. 314 2001 45 48
-
(2001)
Neurosci. Lett.
, vol.314
, pp. 45-48
-
-
Bogdanovic, N.1
Bretillon, L.2
Lund, E.G.3
Diczfalusy, U.4
Lannfelt, L.5
Winblad, B.6
Russell, D.W.7
Björkhem, I.8
-
6
-
-
0038265008
-
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
-
E.G. Lund, C. Xie, T. Kotti, S.D. Turley, J.M. Dietschy, and D.W. Russell Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover J. Biol. Chem. 278 2003 22980 22988
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22980-22988
-
-
Lund, E.G.1
Xie, C.2
Kotti, T.3
Turley, S.D.4
Dietschy, J.M.5
Russell, D.W.6
-
7
-
-
67650751079
-
Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain
-
D.W. Russell, R.W. Halford, D.M. Ramirez, R. Shah, and T. Kotti Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain Annu. Rev. Biochem. 78 2009 1017 1040
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 1017-1040
-
-
Russell, D.W.1
Halford, R.W.2
Ramirez, D.M.3
Shah, R.4
Kotti, T.5
-
8
-
-
49649084975
-
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
-
T. Kotti, D.D. Head, C.E. McKenna, and D.W. Russell Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation Proc. Natl. Acad. Sci. USA 105 2008 11394 11399
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11394-11399
-
-
Kotti, T.1
Head, D.D.2
McKenna, C.E.3
Russell, D.W.4
-
9
-
-
34249848111
-
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
-
A. Radhakrishnan, Y. Ikeda, H.J. Kwon, M.S. Brown, and J.L. Goldstein Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig Proc. Natl. Acad. Sci. USA 104 2007 6511 6518
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 6511-6518
-
-
Radhakrishnan, A.1
Ikeda, Y.2
Kwon, H.J.3
Brown, M.S.4
Goldstein, J.L.5
-
10
-
-
45549102514
-
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: Quantitative changes to the cortical neuron proteome
-
Y. Wang, S. Muneton, J. Sjövall, J.N. Jovanovic, and W.J. Griffiths The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome J. Proteome Res. 7 2008 1606 1614
-
(2008)
J. Proteome Res.
, vol.7
, pp. 1606-1614
-
-
Wang, Y.1
Muneton, S.2
Sjövall, J.3
Jovanovic, J.N.4
Griffiths, W.J.5
-
11
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
-
B.A. Janowski, M.J. Grogan, S.A. Jones, G.B. Wisely, S.A. Kliewer, E.J. Corey, and D.J. Mangelsdorf Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta Proc. Natl. Acad. Sci. USA 96 1999 266 271
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 266-271
-
-
Janowski, B.A.1
Grogan, M.J.2
Jones, S.A.3
Wisely, G.B.4
Kliewer, S.A.5
Corey, E.J.6
Mangelsdorf, D.J.7
-
12
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
J.M. Lehmann, S.A. Kliewer, L.B. Moore, T.A. Smith-Oliver, B.B. Oliver, J.L. Su, S.S. Sundseth, D.A. Winegar, D.E. Blanchard, T.A. Spencer, and T.M. Willson Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway J. Biol. Chem. 272 1997 3137 3140
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
13
-
-
70349309626
-
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells
-
P. Sacchetti, K.M. Sousa, A.C. Hall, I. Liste, K.R. Steffensen, S. Theofilopoulos, C.L. Parish, C. Hazenberg, L.A. Richter, O. Hovatta, J.A. Gustafsson, and E. Arenas Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells Cell Stem Cell 5 2009 409 419
-
(2009)
Cell Stem Cell
, vol.5
, pp. 409-419
-
-
Sacchetti, P.1
Sousa, K.M.2
Hall, A.C.3
Liste, I.4
Steffensen, K.R.5
Theofilopoulos, S.6
Parish, C.L.7
Hazenberg, C.8
Richter, L.A.9
Hovatta, O.10
Gustafsson, J.A.11
Arenas, E.12
-
14
-
-
84872677234
-
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
-
S. Theofilopoulos, Y. Wang, S.S. Kitambi, P. Sacchetti, K.M. Sousa, K. Bodin, J. Kirk, C. Salto, M. Gustafsson, E.M. Toledo, K. Karu, J.A. Gustafsson, K.R. Steffensen, P. Ernfors, J. Sjövall, W.J. Griffiths, and E. Arenas Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis Nat. Chem. Biol. 9 2012 126 133
-
(2012)
Nat. Chem. Biol.
, vol.9
, pp. 126-133
-
-
Theofilopoulos, S.1
Wang, Y.2
Kitambi, S.S.3
Sacchetti, P.4
Sousa, K.M.5
Bodin, K.6
Kirk, J.7
Salto, C.8
Gustafsson, M.9
Toledo, E.M.10
Karu, K.11
Gustafsson, J.A.12
Steffensen, K.R.13
Ernfors, P.14
Sjövall, J.15
Griffiths, W.J.16
Arenas, E.17
-
15
-
-
34147118488
-
Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols
-
K. Karu, M. Hornshaw, G. Woffendin, K. Bodin, M. Hamberg, G. Alvelius, J. Sjövall, J. Turton, Y. Wang, and W.J. Griffiths Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols J. Lipid Res. 48 2007 976 987
-
(2007)
J. Lipid Res.
, vol.48
, pp. 976-987
-
-
Karu, K.1
Hornshaw, M.2
Woffendin, G.3
Bodin, K.4
Hamberg, M.5
Alvelius, G.6
Sjövall, J.7
Turton, J.8
Wang, Y.9
Griffiths, W.J.10
-
16
-
-
80051471394
-
Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: Monitoring of cholesterol autoxidation
-
K. Karu, J. Turton, Y. Wang, and W.J. Griffiths Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation Chem. Phys. Lipids 164 2011 411 424
-
(2011)
Chem. Phys. Lipids
, vol.164
, pp. 411-424
-
-
Karu, K.1
Turton, J.2
Wang, Y.3
Griffiths, W.J.4
-
17
-
-
41249093188
-
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
-
J.G. McDonald, B.M. Thompson, E.C. McCrum, and D.W. Russell Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry Methods Enzymol. 432 2007 145 170
-
(2007)
Methods Enzymol.
, vol.432
, pp. 145-170
-
-
McDonald, J.G.1
Thompson, B.M.2
McCrum, E.C.3
Russell, D.W.4
-
18
-
-
84867351590
-
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
-
A. Meljon, S. Theofilopoulos, C.H. Shackleton, G.L. Watson, N.B. Javitt, H.J. Knolker, R. Saini, E. Arenas, Y. Wang, and W.J. Griffiths Analysis of bioactive oxysterols in newborn mouse brain by LC/MS J. Lipid Res. 53 2012 2469 2483
-
(2012)
J. Lipid Res.
, vol.53
, pp. 2469-2483
-
-
Meljon, A.1
Theofilopoulos, S.2
Shackleton, C.H.3
Watson, G.L.4
Javitt, N.B.5
Knolker, H.J.6
Saini, R.7
Arenas, E.8
Wang, Y.9
Griffiths, W.J.10
-
19
-
-
77951156488
-
Cerebrospinal fluid steroidomics: Are bioactive bile acids present in brain?
-
M. Ogundare, S. Theofilopoulos, A. Lockhart, L.J. Hall, E. Arenas, J. Sjövall, A.G. Brenton, Y. Wang, and W.J. Griffiths Cerebrospinal fluid steroidomics: Are bioactive bile acids present in brain? J. Biol. Chem. 285 2010 4666 4679
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 4666-4679
-
-
Ogundare, M.1
Theofilopoulos, S.2
Lockhart, A.3
Hall, L.J.4
Arenas, E.5
Sjövall, J.6
Brenton, A.G.7
Wang, Y.8
Griffiths, W.J.9
-
20
-
-
0034175781
-
Cholesterol oxidase: Sources, physical properties and analytical applications
-
J. MacLachlan, A.T. Wotherspoon, R.O. Ansell, and C.J. Brooks Cholesterol oxidase: sources, physical properties and analytical applications J. Steroid Biochem. Mol. Biol. 72 2000 169 195
-
(2000)
J. Steroid Biochem. Mol. Biol.
, vol.72
, pp. 169-195
-
-
Maclachlan, J.1
Wotherspoon, A.T.2
Ansell, R.O.3
Brooks, C.J.4
-
21
-
-
65349142492
-
Targeted lipidomic analysis of oxysterols in the embryonic central nervous system
-
Y. Wang, K.M. Sousa, K. Bodin, S. Theofilopoulos, P. Sacchetti, M. Hornshaw, G. Woffendin, K. Karu, J. Sjövall, E. Arenas, and W.J. Griffiths Targeted lipidomic analysis of oxysterols in the embryonic central nervous system Mol. Biosyst. 5 2009 529 541
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 529-541
-
-
Wang, Y.1
Sousa, K.M.2
Bodin, K.3
Theofilopoulos, S.4
Sacchetti, P.5
Hornshaw, M.6
Woffendin, G.7
Karu, K.8
Sjövall, J.9
Arenas, E.10
Griffiths, W.J.11
-
22
-
-
0141459395
-
Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration
-
C. Xie, E.G. Lund, S.D. Turley, D.W. Russell, and J.M. Dietschy Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration J. Lipid Res. 44 2003 1780 1789
-
(2003)
J. Lipid Res.
, vol.44
, pp. 1780-1789
-
-
Xie, C.1
Lund, E.G.2
Turley, S.D.3
Russell, D.W.4
Dietschy, J.M.5
-
23
-
-
0023000290
-
24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase
-
F.R. Taylor, A.A. Kandutsch, A.K. Gayen, J.A. Nelson, S.S. Nelson, S. Phirwa, and T.A. Spencer 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase J. Biol. Chem. 261 1986 15039 15044
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 15039-15044
-
-
Taylor, F.R.1
Kandutsch, A.A.2
Gayen, A.K.3
Nelson, J.A.4
Nelson, S.S.5
Phirwa, S.6
Spencer, T.A.7
-
24
-
-
0019420840
-
Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide
-
J.A. Nelson, S.R. Steckbeck, and T.A. Spencer Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide J. Biol. Chem. 256 1981 1067 1068
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 1067-1068
-
-
Nelson, J.A.1
Steckbeck, S.R.2
Spencer, T.A.3
-
25
-
-
0842303768
-
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
-
M. Heverin, N. Bogdanovic, D. Lütjohann, T. Bayer, I. Pikuleva, L. Bretillon, U. Diczfalusy, B. Winblad, and I. Björkhem Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease J. Lipid Res. 45 2004 186 193
-
(2004)
J. Lipid Res.
, vol.45
, pp. 186-193
-
-
Heverin, M.1
Bogdanovic, N.2
Lütjohann, D.3
Bayer, T.4
Pikuleva, I.5
Bretillon, L.6
Diczfalusy, U.7
Winblad, B.8
Björkhem, I.9
-
26
-
-
70349730033
-
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
-
D.R. Bauman, A.D. Bitmansour, J.G. McDonald, B.M. Thompson, G. Liang, and D.W. Russell 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production Proc. Natl. Acad. Sci. USA 106 2009 16764 16769
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 16764-16769
-
-
Bauman, D.R.1
Bitmansour, A.D.2
McDonald, J.G.3
Thompson, B.M.4
Liang, G.5
Russell, D.W.6
-
27
-
-
78649731204
-
Editorial: 25-Hydroxycholesterol: A new life in immunology
-
J.G. McDonald, and D.W. Russell Editorial: 25-Hydroxycholesterol: a new life in immunology J. Leukocyte Biol. 88 2010 1071 1072
-
(2010)
J. Leukocyte Biol.
, vol.88
, pp. 1071-1072
-
-
McDonald, J.G.1
Russell, D.W.2
-
28
-
-
70349757041
-
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
-
U. Diczfalusy, K.E. Olofsson, A.M. Carlsson, M. Gong, D.T. Golenbock, O. Rooyackers, U. Flaring, and H. Björkbacka Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide J. Lipid Res. 50 2009 2258 2264
-
(2009)
J. Lipid Res.
, vol.50
, pp. 2258-2264
-
-
Diczfalusy, U.1
Olofsson, K.E.2
Carlsson, A.M.3
Gong, M.4
Golenbock, D.T.5
Rooyackers, O.6
Flaring, U.7
Björkbacka, H.8
-
29
-
-
47049112744
-
Cholesterol, reactive oxygen species, and the formation of biologically active mediators
-
R.C. Murphy, and K.M. Johnson Cholesterol, reactive oxygen species, and the formation of biologically active mediators J. Biol. Chem. 283 2008 15521 15525
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15521-15525
-
-
Murphy, R.C.1
Johnson, K.M.2
-
30
-
-
0037439527
-
Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status
-
L. Iuliano, F. Micheletta, S. Natoli, C.S. Ginanni, M. Iappelli, W. Elisei, L. Giovannelli, F. Violi, and U. Diczfalusy Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status Anal. Biochem. 312 2003 217 223
-
(2003)
Anal. Biochem.
, vol.312
, pp. 217-223
-
-
Iuliano, L.1
Micheletta, F.2
Natoli, S.3
Ginanni, C.S.4
Iappelli, M.5
Elisei, W.6
Giovannelli, L.7
Violi, F.8
Diczfalusy, U.9
-
31
-
-
0342316532
-
Oxysterols: Modulators of cholesterol metabolism and other processes
-
G.J. Schroepfer Jr. Oxysterols: modulators of cholesterol metabolism and other processes Physiol. Rev. 80 2000 361 554
-
(2000)
Physiol. Rev.
, vol.80
, pp. 361-554
-
-
Schroepfer, Jr.G.J.1
-
32
-
-
84867031028
-
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
-
N.J. Spann, L.X. Garmire, J.G. McDonald, D.S. Myers, S.B. Milne, N. Shibata, D. Reichart, J.N. Fox, I. Shaked, D. Heudobler, C.R. Raetz, E.W. Wang, S.L. Kelly, M.C. Sullards, R.C. Murphy, A.H. Merrill Jr., H.A. Brown, E.A. Dennis, A.C. Li, K. Ley, S. Tsimikas, E. Fahy, S. Subramaniam, O. Quehenberger, D.W. Russell, and C.K. Glass Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses Cell 151 2012 138 152
-
(2012)
Cell
, vol.151
, pp. 138-152
-
-
Spann, N.J.1
Garmire, L.X.2
McDonald, J.G.3
Myers, D.S.4
Milne, S.B.5
Shibata, N.6
Reichart, D.7
Fox, J.N.8
Shaked, I.9
Heudobler, D.10
Raetz, C.R.11
Wang, E.W.12
Kelly, S.L.13
Sullards, M.C.14
Murphy, R.C.15
Merrill, Jr.A.H.16
Brown, H.A.17
Dennis, E.A.18
Li, A.C.19
Ley, K.20
Tsimikas, S.21
Fahy, E.22
Subramaniam, S.23
Quehenberger, O.24
Russell, D.W.25
Glass, C.K.26
more..
-
33
-
-
33748792007
-
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
-
C. Yang, J.G. McDonald, A. Patel, Y. Zhang, M. Umetani, F. Xu, E.J. Westover, D.F. Covey, D.J. Mangelsdorf, J.C. Cohen, and H.H. Hobbs Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands J. Biol. Chem. 281 2006 27816 27826
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 27816-27826
-
-
Yang, C.1
McDonald, J.G.2
Patel, A.3
Zhang, Y.4
Umetani, M.5
Xu, F.6
Westover, E.J.7
Covey, D.F.8
Mangelsdorf, D.J.9
Cohen, J.C.10
Hobbs, H.H.11
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